Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL134W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.301 | 2.60E-71 | YMR111C | YMR111C | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress |
0.281 | 7.83E-62 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
0.237 | 2.88E-44 | YIL160C | POT1 | hom | 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids |
0.220 | 3.92E-38 | YOL141W | PPM2 | hom | AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p |
0.220 | 6.92E-38 | YBR118W | TEF2 | hom | Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication |
0.216 | 6.87E-37 | YPL121C | MEI5 | hom | Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p |
0.209 | 2.24E-34 | YOR093C_p | YOR093C_p | hom | Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents |
0.206 | 2.07E-33 | YLR205C | HMX1 | hom | ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants |
0.195 | 4.29E-30 | YGR149W_p | YGR149W_p | hom | Putative protein of unknown function; predicted to be an integal membrane protein |
0.195 | 4.71E-30 | YDR205W | MSC2 | hom | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids |
0.185 | 2.50E-27 | YGR032W | GSC2 | hom | Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) |
0.183 | 1.01E-26 | YGR058W | PEF1 | hom | Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly |
0.182 | 2.40E-26 | YOR231W | MKK1 | hom | MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication |
0.181 | 4.31E-26 | YGL081W_p | YGL081W_p | hom | Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis |
0.180 | 6.19E-26 | YJR127C | RSF2 | hom | Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress |