HIPHOP chemogenomics database

YGL134W / PCL10

Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL134W / PCL10

Click on Significant Values for Screen Details

Top fitness defect scores for YGL134W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_58	0957-0393	6.31	9.0 µM	1.74E-13	cell wall	194	1.39E-10
2	SGTC_2347	9049783	5.86	174.8 µM	7.41E-12		9	2.37E-9
3	SGTC_57	miconazole	5.01	162.5 nM	3.92E-9	ergosterol depletion effects on membrane	17	2.74E-7
4	SGTC_2693	st077581	4.49	40.7 µM	1.17E-7		21	3.61E-6
5	SGTC_63	0099-0242	4.42	26.7 µM	1.72E-7	mitochondrial stress	73	4.84E-6
6	SGTC_632	0781-2353	3.64	4.7 µM	1.40E-5	Golgi	56	1.38E-4
7	SGTC_798	1287-0182	3.61	476.0 µM	1.61E-5		30	1.53E-4
8	SGTC_1346	1488-2224	3.58	62.4 µM	1.88E-5		24	1.72E-4
9	SGTC_2013	4024628	3.58	200.0 µM	1.90E-5		60	1.74E-4
10	SGTC_865	0488-0499	3.29	301.0 µM	7.77E-5		37	5.10E-4
11	SGTC_1635	st007035	3.21	42.4 µM	1.07E-4		272	6.53E-4
12	SGTC_1851	st056236	3.20	18.9 µM	1.16E-4		40	6.92E-4
13	SGTC_2375	9072683	3.19	200.0 µM	1.23E-4	mitochondrial processes	45	7.24E-4
14	SGTC_2316	5844804	3.17	197.4 µM	1.32E-4		79	7.66E-4
15	SGTC_1121	fusaric acid	3.11	630.5 nM	1.70E-4		71	9.27E-4
16	SGTC_2386	9075165	2.95	157.4 µM	3.38E-4		34	0.00158
17	SGTC_2692	st077426	2.93	47.7 µM	3.68E-4		73	0.00168
18	SGTC_2341	7987486	2.80	176.7 µM	6.35E-4		81	0.00255
19	SGTC_716	1683-5115	2.80	658.0 µM	6.37E-4		87	0.00256
20	SGTC_2372	9071633	2.75	200.0 µM	7.72E-4		63	0.00297

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.301	2.60E-71	YMR111C	YMR111C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.281	7.83E-62	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.237	2.88E-44	YIL160C	POT1	hom	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.220	3.92E-38	YOL141W	PPM2	hom	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.220	6.92E-38	YBR118W	TEF2	hom	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.216	6.87E-37	YPL121C	MEI5	hom	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
0.209	2.24E-34	YOR093C_p	YOR093C_p	hom	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.206	2.07E-33	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.195	4.29E-30	YGR149W_p	YGR149W_p	hom	Putative protein of unknown function; predicted to be an integal membrane protein
0.195	4.71E-30	YDR205W	MSC2	hom	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.185	2.50E-27	YGR032W	GSC2	hom	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.183	1.01E-26	YGR058W	PEF1	hom	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.182	2.40E-26	YOR231W	MKK1	hom	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.181	4.31E-26	YGL081W_p	YGL081W_p	hom	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.180	6.19E-26	YJR127C	RSF2	hom	Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress