YGL138C_p

Putative protein of unknown function; has no significant sequence similarity to any known protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL138C / YGL138C

Click on Significant Values for Screen Details ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.41|P-value:1.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.31|P-value:2.09E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.36|P-value:1.70E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.99|P-value:7.42E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.23|P-value:2.20E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.91|P-value:9.90E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.01|P-value:5.40E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.22|P-value:3.09E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.19|P-value:3.46E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.21|P-value:3.20E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:5.76E-4 ID:SGTC_2537|Compound:larixol|FD-Score:2.93|P-value:9.34E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.90|P-value:8.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.83|P-value:1.59E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-5.19|P-value:9.87E-9 ID:SGTC_2956|Compound:9076196|FD-Score:4.19|P-value:3.94E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.77|P-value:2.98E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.86|P-value:1.38E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.24|P-value:2.77E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.55|P-value:7.82E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.85|P-value:1.47E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:1.62E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.02|P-value:5.19E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.02|P-value:6.57E-6 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.41|P-value:1.05E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.31|P-value:2.09E-4 ID:SGTC_417|Compound:st075190|FD-Score:3.19|P-value:3.45E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.36|P-value:1.70E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.28|P-value:2.41E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:2.99|P-value:7.42E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.23|P-value:2.20E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.51|P-value:9.37E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.91|P-value:9.90E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.01|P-value:5.40E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.22|P-value:3.09E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.44|P-value:1.25E-4 ID:SGTC_2301|Compound:7769476|FD-Score:2.94|P-value:8.75E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.19|P-value:3.46E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.21|P-value:3.20E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.12|P-value:4.50E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.06|P-value:5.76E-4 ID:SGTC_2537|Compound:larixol|FD-Score:2.93|P-value:9.34E-4 ID:SGTC_2803|Compound:7707263|FD-Score:-2.90|P-value:8.14E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.83|P-value:1.59E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-5.19|P-value:9.87E-9 ID:SGTC_2956|Compound:9076196|FD-Score:4.19|P-value:3.94E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.77|P-value:2.98E-5 ID:SGTC_2958|Compound:9077254|FD-Score:-3.86|P-value:1.38E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.45|P-value:1.18E-4 ID:SGTC_3125|Compound:9127534|FD-Score:3.24|P-value:2.77E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.55|P-value:7.82E-5 ID:SGTC_3192|Compound:9110362|FD-Score:3.20|P-value:3.32E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.85|P-value:1.47E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:1.62E-5 ID:SGTC_3272|Compound:9137413|FD-Score:-3.02|P-value:5.19E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-4.02|P-value:6.57E-6

Top fitness defect scores for YGL138C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2956 9076196 4.19 2.5 µM 3.94E-6 11 1.40E-5
2 SGTC_2957 9076800 3.77 11.5 µM 2.98E-5 25 8.28E-5
3 SGTC_3146 9095609 3.55 49.5 µM 7.82E-5 26 1.93E-4
4 SGTC_1268 0828-0275 3.51 2.5 µM 9.37E-5 37 2.27E-4
5 SGTC_3124 9127567 3.45 49.5 µM 1.18E-4 DNA damage response 29 2.78E-4
6 SGTC_2119 5528445 3.44 120.6 µM 1.25E-4 39 2.91E-4
7 SGTC_456 gingerol 3.36 170.0 µM 1.70E-4 39 3.83E-4
8 SGTC_415 dibenzyl ketone 3.31 100.0 µM 2.09E-4 28 4.59E-4
9 SGTC_459 nigericin 3.28 15.3 µM 2.41E-4 89 5.21E-4
10 SGTC_3125 9127534 3.24 49.5 µM 2.77E-4 28 5.88E-4
11 SGTC_1976 st070609 3.22 63.5 µM 3.09E-4 32 6.47E-4
12 SGTC_2425 5628681 3.21 7.8 µM 3.20E-4 64 6.67E-4
13 SGTC_3192 9110362 3.20 49.5 µM 3.32E-4 mitochondrial processes 27 6.90E-4
14 SGTC_417 st075190 3.19 100.0 µM 3.45E-4 36 7.14E-4
15 SGTC_2356 9061756 3.19 189.0 µM 3.46E-4 24 7.16E-4
16 SGTC_2429 5902844 3.12 64.4 µM 4.50E-4 69 9.02E-4
17 SGTC_2490 carminic acid 3.06 95.4 µM 5.76E-4 26 0.00112
18 SGTC_495 decylubiquinone 2.99 155.0 µM 7.42E-4 copper-dependent oxidative stress 77 0.00140
19 SGTC_2301 7769476 2.94 200.0 µM 8.75E-4 54 0.00162
20 SGTC_2537 larixol 2.93 68.9 µM 9.34E-4 81 0.00172

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 3.70E-25 YGL139W FLC3 hom Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
0.158 3.35E-20 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.134 5.28E-15 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.116 1.67E-11 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.111 1.23E-10 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.109 2.39E-10 YLR285C-A_p YLR285C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.108 3.23E-10 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.099 1.02E-8 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.094 4.38E-8 YDR179C CSN9 hom Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
0.094 4.63E-8 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.094 4.72E-8 YOL150C_d YOL150C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 6.38E-8 YJR099W YUH1 hom Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
0.088 3.11E-7 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.085 7.48E-7 YBR265W TSC10 het 3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family
0.083 1.49E-6 YCL069W VBA3 hom Permease of basic amino acids in the vacuolar membrane