YGL139W / FLC3

Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL139W / FLC3

Click on Significant Values for Screen Details ID:SGTC_296|Compound:1222-0039|FD-Score:3.64|P-value:4.02E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.86|P-value:8.95E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.29|P-value:1.66E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.13|P-value:3.26E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.75|P-value:2.21E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.61|P-value:4.14E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.25|P-value:1.95E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-2.94|P-value:6.78E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.90|P-value:8.35E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.07|P-value:4.04E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.13|P-value:3.25E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.80|P-value:1.87E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.98|P-value:7.79E-6 ID:SGTC_2029|Compound:5175081|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.53|P-value:3.95E-7 ID:SGTC_2112|Compound:5488546|FD-Score:-2.89|P-value:8.07E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.71|P-value:1.63E-7 ID:SGTC_2316|Compound:5844804|FD-Score:3.55|P-value:5.83E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.05|P-value:4.78E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.07|P-value:4.41E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.15|P-value:3.26E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.84|P-value:1.45E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.66|P-value:3.25E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.08|P-value:4.28E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.06|P-value:4.56E-4 ID:SGTC_3160|Compound:9100216|FD-Score:2.98|P-value:6.15E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.97|P-value:6.01E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.64|P-value:4.02E-5 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.86|P-value:8.95E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:4.29|P-value:1.66E-6 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.13|P-value:3.26E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.75|P-value:2.21E-5 ID:SGTC_1201|Compound:1889-3372|FD-Score:-3.61|P-value:4.14E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.25|P-value:1.95E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-2.94|P-value:6.78E-4 ID:SGTC_1753|Compound:st043925|FD-Score:2.90|P-value:8.35E-4 ID:SGTC_1958|Compound:st076513|FD-Score:-3.07|P-value:4.04E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:-3.13|P-value:3.25E-4 ID:SGTC_1973|Compound:st070275|FD-Score:3.80|P-value:1.87E-5 ID:SGTC_1976|Compound:st070609|FD-Score:3.98|P-value:7.79E-6 ID:SGTC_2029|Compound:5175081|FD-Score:-3.13|P-value:3.22E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-4.53|P-value:3.95E-7 ID:SGTC_2112|Compound:5488546|FD-Score:-2.89|P-value:8.07E-4 ID:SGTC_2120|Compound:5538279|FD-Score:4.71|P-value:1.63E-7 ID:SGTC_2316|Compound:5844804|FD-Score:3.55|P-value:5.83E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.05|P-value:4.78E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.07|P-value:4.41E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.15|P-value:3.26E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.84|P-value:1.45E-5 ID:SGTC_2888|Compound:9058547|FD-Score:-3.66|P-value:3.25E-5 ID:SGTC_2917|Compound:7979103|FD-Score:3.08|P-value:4.28E-4 ID:SGTC_2925|Compound:9010536|FD-Score:2.93|P-value:7.59E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.06|P-value:4.56E-4 ID:SGTC_3160|Compound:9100216|FD-Score:2.98|P-value:6.15E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-2.97|P-value:6.01E-4

Top fitness defect scores for YGL139W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2120 5538279 4.71 152.0 µM 1.63E-7 8 1.25E-6
2 SGTC_432 NS 1619 4.29 61.3 µM 1.66E-6 22 9.02E-6
3 SGTC_1976 st070609 3.98 63.5 µM 7.79E-6 12 3.39E-5
4 SGTC_1973 st070275 3.80 50.2 µM 1.87E-5 11 7.16E-5
5 SGTC_296 1222-0039 3.64 74.9 µM 4.02E-5 18 1.38E-4
6 SGTC_2316 5844804 3.55 197.4 µM 5.83E-5 52 1.89E-4
7 SGTC_2602 kawain 3.15 100.0 µM 3.26E-4 66 8.28E-4
8 SGTC_2917 7979103 3.08 53.8 µM 4.28E-4 72 0.00105
9 SGTC_2537 larixol 3.07 68.9 µM 4.41E-4 65 0.00107
10 SGTC_3080 9117754 3.06 49.5 µM 4.56E-4 51 0.00110
11 SGTC_2394 5221648 3.05 200.0 µM 4.78E-4 64 0.00115
12 SGTC_3160 9100216 2.98 49.5 µM 6.15E-4 24 0.00143
13 SGTC_2925 9010536 2.93 32.5 µM 7.59E-4 azole & statin 103 0.00171
14 SGTC_1753 st043925 2.90 64.0 µM 8.35E-4 45 0.00186
15 SGTC_738 1315-0003 2.85 72.4 µM 0.00101 71 0.00219
16 SGTC_2514 salinomycin 2.85 42.7 µM 0.00101 118 0.00220
17 SGTC_2098 5376439 2.85 882.5 nM 0.00102 54 0.00220
18 SGTC_1262 0737-0114 2.83 49.6 µM 0.00110 82 0.00235
19 SGTC_2107 5363541 2.81 170.2 µM 0.00118 51 0.00250
20 SGTC_1235 benzylparaben 2.76 21.5 µM 0.00142 62 0.00293

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 1.56E-27 YBL081W_p YBL081W_p hom Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport
0.178 3.70E-25 YGL138C_p YGL138C_p hom Putative protein of unknown function; has no significant sequence similarity to any known protein
0.173 8.32E-24 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.144 5.54E-17 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.141 2.00E-16 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.137 1.92E-15 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.128 8.94E-14 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.126 3.34E-13 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.122 1.85E-12 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.121 1.88E-12 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.118 7.60E-12 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.116 1.37E-11 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.115 2.20E-11 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.113 5.96E-11 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.110 1.98E-10 YGR194C XKS1 hom Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains