YGL140C_p

Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL140C / YGL140C

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:2.92|P-value:2.63E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.46|P-value:2.90E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.12|P-value:7.95E-7 ID:SGTC_318|Compound:1488-0629|FD-Score:4.63|P-value:2.15E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:2.61|P-value:9.40E-4 ID:SGTC_398|Compound:bronopol|FD-Score:2.68|P-value:7.23E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.86|P-value:3.37E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.36|P-value:4.74E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.59|P-value:1.00E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.65|P-value:7.54E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:2.64|P-value:8.37E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:2.61|P-value:9.45E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.61|P-value:9.48E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.21|P-value:6.77E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.25|P-value:2.43E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.09|P-value:6.09E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.85|P-value:3.46E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.45|P-value:2.07E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.07|P-value:1.81E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.10|P-value:1.17E-4 ID:SGTC_1695|Compound:st026914|FD-Score:2.78|P-value:4.79E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.62|P-value:9.22E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.09|P-value:1.20E-4 ID:SGTC_1891|Compound:st059073|FD-Score:2.72|P-value:6.04E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.34|P-value:5.13E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.30|P-value:4.42E-5 ID:SGTC_2177|Compound:5811945|FD-Score:2.60|P-value:9.63E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.02|P-value:1.67E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-2.74|P-value:7.42E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.79|P-value:4.56E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.94|P-value:3.21E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-2.67|P-value:9.95E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.64|P-value:8.19E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.83|P-value:2.74E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.14|P-value:9.47E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.44|P-value:3.13E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.60|P-value:1.82E-11 ID:SGTC_3319|Compound:9138450|FD-Score:-2.74|P-value:7.45E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:2.92|P-value:2.63E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.46|P-value:2.90E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:-4.12|P-value:7.95E-7 ID:SGTC_318|Compound:1488-0629|FD-Score:4.63|P-value:2.15E-8 ID:SGTC_372|Compound:0155-0182|FD-Score:2.61|P-value:9.40E-4 ID:SGTC_398|Compound:bronopol|FD-Score:2.68|P-value:7.23E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:2.86|P-value:3.37E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.36|P-value:4.74E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:3.59|P-value:1.00E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.65|P-value:7.54E-6 ID:SGTC_842|Compound:0271-0008|FD-Score:2.64|P-value:8.37E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:2.61|P-value:9.45E-4 ID:SGTC_1075|Compound:aripiprazole|FD-Score:2.61|P-value:9.48E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:3.21|P-value:6.77E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.25|P-value:2.43E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:4.09|P-value:6.09E-7 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.85|P-value:3.46E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.45|P-value:2.07E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.07|P-value:1.81E-4 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.10|P-value:1.17E-4 ID:SGTC_1695|Compound:st026914|FD-Score:2.78|P-value:4.79E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:2.62|P-value:9.22E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.09|P-value:1.20E-4 ID:SGTC_1891|Compound:st059073|FD-Score:2.72|P-value:6.04E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-3.34|P-value:5.13E-5 ID:SGTC_2003|Compound:4023581|FD-Score:3.30|P-value:4.42E-5 ID:SGTC_2177|Compound:5811945|FD-Score:2.60|P-value:9.63E-4 ID:SGTC_2278|Compound:7948257|FD-Score:3.02|P-value:1.67E-4 ID:SGTC_2388|Compound:9080168|FD-Score:-2.74|P-value:7.42E-4 ID:SGTC_2402|Compound:5553605|FD-Score:2.79|P-value:4.56E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-2.94|P-value:3.21E-4 ID:SGTC_2601|Compound:securinine|FD-Score:-2.67|P-value:9.95E-4 ID:SGTC_3177|Compound:9107506|FD-Score:2.64|P-value:8.19E-4 ID:SGTC_3186|Compound:9110464|FD-Score:3.83|P-value:2.74E-6 ID:SGTC_3217|Compound:9129673|FD-Score:3.14|P-value:9.47E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.44|P-value:3.13E-5 ID:SGTC_3307|Compound:9126885|FD-Score:5.60|P-value:1.82E-11 ID:SGTC_3319|Compound:9138450|FD-Score:-2.74|P-value:7.45E-4

Top fitness defect scores for YGL140C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3307 9126885 5.60 69.3 µM 1.82E-11 6 1.09E-8
2 SGTC_318 1488-0629 4.63 67.2 µM 2.15E-8 copper-dependent oxidative stress 17 1.85E-6
3 SGTC_1131 3454-3128 4.25 32.3 µM 2.43E-7 31 1.08E-5
4 SGTC_1132 3456-3614 4.09 2.5 µM 6.09E-7 tubulin folding & SWR complex 38 2.11E-5
5 SGTC_3186 9110464 3.83 49.5 µM 2.74E-6 RPP1 & pyrimidine depletion 16 6.32E-5
6 SGTC_773 4358-1457 3.65 44.6 µM 7.54E-6 54 1.32E-4
7 SGTC_739 1486-1183 3.59 203.0 µM 1.00E-5 25 1.63E-4
8 SGTC_1360 1598-0022 3.45 39.8 µM 2.07E-5 ERG2 49 2.76E-4
9 SGTC_2003 4023581 3.30 200.0 µM 4.42E-5 cell wall signaling 59 4.81E-4
10 SGTC_1086 cerivastatin 3.21 2.2 µM 6.77E-5 azole & statin 29 6.58E-4
11 SGTC_3217 9129673 3.14 49.5 µM 9.47E-5 81 8.41E-4
12 SGTC_1596 piperlongumine 3.10 63.0 µM 1.17E-4 50 9.83E-4
13 SGTC_1882 5615643 3.09 20.0 µM 1.20E-4 TRP & mitochondrial translation 52 0.00100
14 SGTC_2278 7948257 3.02 134.3 µM 1.67E-4 49 0.00127
15 SGTC_3 0833-0587 2.92 95.6 µM 2.63E-4 redox potentiating 63 0.00178
16 SGTC_400 oxethazaine 2.86 37.5 µM 3.37E-4 calcium & mitochondrial duress 65 0.00213
17 SGTC_1214 0358-0031 2.85 63.7 µM 3.46E-4 70 0.00217
18 SGTC_2402 5553605 2.79 200.0 µM 4.56E-4 100 0.00266
19 SGTC_1695 st026914 2.78 34.5 µM 4.79E-4 83 0.00276
20 SGTC_1891 st059073 2.72 26.2 µM 6.04E-4 TSC3-RPN4 91 0.00327

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.76E-20 YDL201W TRM8 hom Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.154 3.01E-19 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
0.128 1.26E-13 YOR242C SSP2 hom Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
0.126 2.31E-13 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.126 2.96E-13 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.124 6.51E-13 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.121 1.78E-12 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.121 1.87E-12 YOL054W PSH1 hom E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
0.111 1.10E-10 YHR122W CIA2 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
0.108 3.79E-10 YDR055W PST1 hom Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.105 1.11E-9 YDR165W TRM82 hom Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p
0.103 2.06E-9 YOR138C RUP1 hom Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress
0.102 3.16E-9 YDR003W RCR2 hom Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication
0.101 4.40E-9 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.100 5.69E-9 YPR168W NUT2 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress