YGL149W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL149W / YGL149W

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.68|P-value:7.84E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.46|P-value:2.31E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.37|P-value:3.50E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.42|P-value:2.23E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.81|P-value:4.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.75|P-value:5.96E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.49|P-value:2.03E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.06|P-value:1.53E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.24|P-value:6.64E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:3.06|P-value:7.66E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.13|P-value:6.49E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.75|P-value:5.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:8.61E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.12|P-value:6.87E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.67|P-value:7.55E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.20|P-value:5.20E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.06|P-value:1.52E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:-4.42|P-value:2.78E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.27|P-value:3.63E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.87|P-value:3.59E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.12|P-value:6.28E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.65|P-value:8.03E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.10|P-value:7.36E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.41|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.65|P-value:3.08E-9 ID:SGTC_2104|Compound:5389443|FD-Score:3.65|P-value:7.97E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.04|P-value:8.25E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.67|P-value:7.52E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.78|P-value:4.72E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.45|P-value:1.81E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.59|P-value:1.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.76|P-value:5.14E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.17|P-value:5.67E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.47|P-value:1.66E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.66|P-value:3.04E-9 ID:SGTC_2696|Compound:st077691|FD-Score:-4.81|P-value:3.81E-7 ID:SGTC_3216|Compound:9129716|FD-Score:-3.03|P-value:9.54E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.68|P-value:7.84E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.46|P-value:2.31E-6 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.37|P-value:3.50E-6 ID:SGTC_166|Compound:k072-0058|FD-Score:-3.42|P-value:2.23E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.81|P-value:4.07E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.13|P-value:6.06E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.75|P-value:5.96E-5 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.49|P-value:2.03E-6 ID:SGTC_752|Compound:1896-0090|FD-Score:3.54|P-value:1.29E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.06|P-value:1.53E-5 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.24|P-value:6.64E-6 ID:SGTC_810|Compound:3825-7150|FD-Score:3.06|P-value:7.66E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.13|P-value:6.49E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:3.08|P-value:7.36E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.75|P-value:5.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.06|P-value:8.61E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.12|P-value:6.87E-4 ID:SGTC_1152|Compound:3909-8331|FD-Score:3.67|P-value:7.55E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.20|P-value:5.20E-4 ID:SGTC_1272|Compound:0839-0021|FD-Score:-4.06|P-value:1.52E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:-4.42|P-value:2.78E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.27|P-value:3.63E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-3.51|P-value:1.56E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.92|P-value:2.55E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.87|P-value:3.59E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.12|P-value:6.28E-4 ID:SGTC_1756|Compound:st041558|FD-Score:4.57|P-value:1.18E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.65|P-value:8.03E-5 ID:SGTC_1835|Compound:st008666|FD-Score:-3.10|P-value:7.36E-4 ID:SGTC_1850|Compound:st056238|FD-Score:-3.41|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.65|P-value:3.08E-9 ID:SGTC_2104|Compound:5389443|FD-Score:3.65|P-value:7.97E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.04|P-value:8.25E-4 ID:SGTC_2427|Compound:5545055|FD-Score:3.67|P-value:7.52E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.78|P-value:4.72E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.45|P-value:1.81E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.59|P-value:1.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.76|P-value:5.14E-7 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.17|P-value:5.67E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.47|P-value:1.66E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-5.66|P-value:3.04E-9 ID:SGTC_2696|Compound:st077691|FD-Score:-4.81|P-value:3.81E-7 ID:SGTC_3216|Compound:9129716|FD-Score:-3.03|P-value:9.54E-4

Top fitness defect scores for YGL149W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1756 st041558 4.57 35.5 µM 1.18E-6 4 2.43E-6
2 SGTC_1293 1000-1278 3.92 195.0 µM 2.55E-5 9 4.42E-5
3 SGTC_427 1354-0053 3.81 47.3 µM 4.07E-5 25 6.86E-5
4 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.78 3.7 µM 4.72E-5 96 7.88E-5
5 SGTC_1077 5-fluorocytosine 3.75 377.0 nM 5.24E-5 exosome 20 8.71E-5
6 SGTC_2427 5545055 3.67 42.8 µM 7.52E-5 23 1.22E-4
7 SGTC_1152 3909-8331 3.67 15.9 µM 7.55E-5 16 1.23E-4
8 SGTC_2104 5389443 3.65 200.0 µM 7.97E-5 20 1.29E-4
9 SGTC_1779 st039427 3.65 55.0 µM 8.03E-5 35 1.30E-4
10 SGTC_752 1896-0090 3.54 130.0 µM 1.29E-4 TSC3-RPN4 26 2.03E-4
11 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.47 100.0 µM 1.66E-4 54 2.58E-4
12 SGTC_2514 salinomycin 3.45 42.7 µM 1.81E-4 75 2.80E-4
13 SGTC_1289 0976-0073 3.27 69.1 µM 3.63E-4 34 5.39E-4
14 SGTC_453 enantio-paf c16 3.13 10.0 µM 6.06E-4 224 8.75E-4
15 SGTC_1750 st081859 3.12 2.4 µM 6.28E-4 endomembrane recycling 241 9.06E-4
16 SGTC_947 3447-0010 3.08 211.0 µM 7.36E-4 48 0.00105
17 SGTC_810 3825-7150 3.06 143.0 µM 7.66E-4 60S ribosome export 33 0.00109
18 SGTC_2338 7999974 3.04 200.0 µM 8.25E-4 61 0.00117
19 SGTC_1012 4112-3522 2.98 18.0 µM 0.00103 56 0.00144
20 SGTC_2709 st078560 2.97 56.0 µM 0.00108 43 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.38E-26 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.178 2.21E-25 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.175 1.93E-24 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.168 1.47E-22 YKL022C CDC16 het Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
0.166 4.17E-22 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.159 2.24E-20 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.153 5.66E-19 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.151 1.20E-18 YLL046C RNP1 hom Ribonucleoprotein that contains two RNA recognition motifs (RRM)
0.148 9.10E-18 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.147 9.52E-18 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.144 6.55E-17 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.142 1.45E-16 YKL205W LOS1 hom Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm
0.141 2.05E-16 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.139 5.51E-16 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.139 6.04E-16 YPL223C GRE1 hom Hydrophilin essential in dessication-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway