YGL153W / PEX14

Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL153W / PEX14

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:6.87E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-6.14|P-value:2.63E-10 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.71|P-value:9.34E-7 ID:SGTC_204|Compound:1543-0184|FD-Score:-6.14|P-value:2.66E-10 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.26|P-value:4.97E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.22|P-value:5.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.19|P-value:6.25E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.48|P-value:2.10E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.27|P-value:1.18E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-4.62|P-value:1.47E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:-5.29|P-value:4.35E-8 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.68|P-value:1.09E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:6.63|P-value:1.06E-11 ID:SGTC_883|Compound:0850-0245|FD-Score:-5.06|P-value:1.53E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.34|P-value:3.63E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.43|P-value:2.08E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:7.84|P-value:1.11E-15 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.27|P-value:4.67E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.20|P-value:1.11E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.78|P-value:6.43E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.16|P-value:1.30E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.05|P-value:2.14E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.29|P-value:4.26E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-3.51|P-value:1.89E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.72|P-value:8.28E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.12|P-value:7.99E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.09|P-value:8.73E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.15|P-value:7.20E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.54|P-value:1.72E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.39|P-value:4.48E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-4.05|P-value:2.07E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.85|P-value:4.88E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.82|P-value:5.58E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.74|P-value:7.61E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.34|P-value:3.74E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.90|P-value:3.61E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.16|P-value:6.77E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:7.64|P-value:5.64E-15 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.58|P-value:1.81E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.57|P-value:1.95E-6 ID:SGTC_2570|Compound:licareol|FD-Score:5.29|P-value:4.45E-8 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.09|P-value:8.84E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.15|P-value:1.34E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.20|P-value:6.03E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.82|P-value:5.61E-7 ID:SGTC_2979|Compound:9012552|FD-Score:-3.15|P-value:7.10E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.16|P-value:7.01E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.08|P-value:1.88E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.16|P-value:7.11E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.17|P-value:6.87E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-6.14|P-value:2.63E-10 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.71|P-value:9.34E-7 ID:SGTC_204|Compound:1543-0184|FD-Score:-6.14|P-value:2.66E-10 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.26|P-value:4.97E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.22|P-value:5.62E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:-3.19|P-value:6.25E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:-3.48|P-value:2.10E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.62|P-value:1.28E-4 ID:SGTC_682|Compound:0kpi-0099|FD-Score:3.63|P-value:1.20E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:6.27|P-value:1.18E-10 ID:SGTC_710|Compound:3448-4187|FD-Score:3.23|P-value:5.44E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-4.62|P-value:1.47E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:-5.29|P-value:4.35E-8 ID:SGTC_868|Compound:0527-0199|FD-Score:-4.68|P-value:1.09E-6 ID:SGTC_873|Compound:0591-4978|FD-Score:4.13|P-value:1.47E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:6.63|P-value:1.06E-11 ID:SGTC_883|Compound:0850-0245|FD-Score:-5.06|P-value:1.53E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:-3.34|P-value:3.63E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.43|P-value:2.08E-8 ID:SGTC_1212|Compound:0520-0165|FD-Score:7.84|P-value:1.11E-15 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.27|P-value:4.67E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:4.20|P-value:1.11E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:-3.78|P-value:6.43E-5 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.16|P-value:1.30E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:4.05|P-value:2.14E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.27|P-value:4.79E-4 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:-3.29|P-value:4.26E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-3.51|P-value:1.89E-4 ID:SGTC_1840|Compound:st055363|FD-Score:-3.72|P-value:8.28E-5 ID:SGTC_1843|Compound:st055809|FD-Score:3.12|P-value:7.99E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.09|P-value:8.73E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.15|P-value:7.20E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.50|P-value:1.95E-4 ID:SGTC_1935|Compound:st074532|FD-Score:3.54|P-value:1.72E-4 ID:SGTC_1936|Compound:st074407|FD-Score:4.39|P-value:4.48E-6 ID:SGTC_1937|Compound:st074714|FD-Score:-4.05|P-value:2.07E-5 ID:SGTC_2093|Compound:5331342|FD-Score:-3.85|P-value:4.88E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.32|P-value:3.94E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.82|P-value:5.58E-5 ID:SGTC_2191|Compound:5911152|FD-Score:-3.74|P-value:7.61E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.34|P-value:3.74E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.90|P-value:3.61E-7 ID:SGTC_2292|Compound:7671323|FD-Score:3.45|P-value:2.47E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.16|P-value:6.77E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.22|P-value:5.64E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.19|P-value:6.44E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:7.64|P-value:5.64E-15 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.58|P-value:1.81E-6 ID:SGTC_2532|Compound:xanthone|FD-Score:3.40|P-value:2.98E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.57|P-value:1.95E-6 ID:SGTC_2570|Compound:licareol|FD-Score:5.29|P-value:4.45E-8 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.09|P-value:8.84E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.15|P-value:1.34E-5 ID:SGTC_2967|Compound:9089538|FD-Score:3.20|P-value:6.03E-4 ID:SGTC_2976|Compound:9009005|FD-Score:4.82|P-value:5.61E-7 ID:SGTC_2979|Compound:9012552|FD-Score:-3.15|P-value:7.10E-4 ID:SGTC_2982|Compound:9019404|FD-Score:-3.24|P-value:5.26E-4 ID:SGTC_3168|Compound:9103419|FD-Score:3.16|P-value:7.01E-4 ID:SGTC_3170|Compound:9103054|FD-Score:4.08|P-value:1.88E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_3347|Compound:9188721|FD-Score:3.16|P-value:7.11E-4

Top fitness defect scores for YGL153W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1212 0520-0165 7.84 585.0 µM 1.11E-15 2 2.22E-15
2 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 7.64 92.6 µM 5.64E-15 1 1.09E-14
3 SGTC_875 0709-0210 6.63 25.7 µM 1.06E-11 fatty acid desaturase (OLE1) 9 1.73E-11
4 SGTC_690 glyoxal 6.27 20.3 µM 1.18E-10 40 1.83E-10
5 SGTC_1203 3992-3522 5.43 103.0 µM 2.08E-8 8 2.89E-8
6 SGTC_2570 licareol 5.29 100.0 µM 4.45E-8 11 6.09E-8
7 SGTC_2249 haloperidol 4.90 116.4 µM 3.61E-7 ergosterol depletion effects on membrane 69 4.73E-7
8 SGTC_2976 9009005 4.82 19.5 µM 5.61E-7 20 7.28E-7
9 SGTC_2533 agelasine 4.57 13.7 µM 1.95E-6 ERG2 35 2.47E-6
10 SGTC_1936 st074407 4.39 74.3 µM 4.48E-6 DNA damage response 20 5.56E-6
11 SGTC_1245 0418-0076 4.20 17.2 µM 1.11E-5 ERG2 24 1.36E-5
12 SGTC_1338 1486-1223 4.16 76.0 µM 1.30E-5 17 1.58E-5
13 SGTC_2756 carbadox 4.15 75.1 µM 1.34E-5 49 1.63E-5
14 SGTC_873 0591-4978 4.13 488.0 µM 1.47E-5 17 1.78E-5
15 SGTC_3170 9103054 4.08 49.5 µM 1.88E-5 60S ribosome export 9 2.26E-5
16 SGTC_1369 1866-0067 4.05 208.0 µM 2.14E-5 RPP1 & pyrimidine depletion 35 2.58E-5
17 SGTC_2126 5251174 3.82 33.9 µM 5.58E-5 38 6.58E-5
18 SGTC_682 0kpi-0099 3.63 17.0 µM 1.20E-4 82 1.40E-4
19 SGTC_557 1315-0110 3.62 16.2 µM 1.28E-4 Golgi 28 1.49E-4
20 SGTC_3305 9127027 3.61 53.8 µM 1.31E-4 24 1.52E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.61E-16 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.118 7.01E-12 YHR180W_d YHR180W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.115 2.54E-11 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.112 7.12E-11 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.111 1.05E-10 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.110 1.49E-10 YIL109C SEC24 het Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
0.110 1.54E-10 YDR419W RAD30 hom DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV
0.103 1.87E-9 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.103 1.90E-9 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.101 4.35E-9 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.100 6.65E-9 YMR018W_p YMR018W_p hom Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
0.097 1.91E-8 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.097 2.02E-8 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.095 3.64E-8 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.093 7.54E-8 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p