YGL166W / CUP2

Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL166W / CUP2

Click on Significant Values for Screen Details ID:SGTC_231|Compound:b-estradiol|FD-Score:3.23|P-value:8.23E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.32|P-value:1.22E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.76|P-value:1.07E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.16|P-value:9.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.24|P-value:6.93E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.22|P-value:7.40E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.23|P-value:1.77E-5 ID:SGTC_1741|Compound:st038134|FD-Score:7.68|P-value:2.78E-14 ID:SGTC_1743|Compound:st037606|FD-Score:3.24|P-value:7.87E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.31|P-value:6.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.99|P-value:4.86E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.18|P-value:2.20E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.22|P-value:1.85E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.66|P-value:1.56E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.92|P-value:7.51E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:4.93E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.16|P-value:9.27E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.39|P-value:4.11E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.36|P-value:1.05E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.49|P-value:3.30E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.32|P-value:6.02E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.52|P-value:2.65E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-5.08|P-value:2.89E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-4.09|P-value:2.82E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:6.42E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.53|P-value:2.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.31|P-value:1.11E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.43|P-value:7.66E-6 ID:SGTC_3282|Compound:9108498|FD-Score:-3.49|P-value:2.95E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_3296|Compound:9122258|FD-Score:7.24|P-value:7.23E-13 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.23|P-value:8.23E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:-3.28|P-value:6.03E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.32|P-value:1.22E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.76|P-value:1.07E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-3.16|P-value:9.09E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.24|P-value:6.93E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:-3.22|P-value:7.40E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.40|P-value:4.56E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.23|P-value:1.77E-5 ID:SGTC_1741|Compound:st038134|FD-Score:7.68|P-value:2.78E-14 ID:SGTC_1743|Compound:st037606|FD-Score:3.24|P-value:7.87E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.31|P-value:6.22E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.99|P-value:4.86E-5 ID:SGTC_1887|Compound:st057648|FD-Score:4.18|P-value:2.20E-5 ID:SGTC_1893|Compound:st059353|FD-Score:4.22|P-value:1.85E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.66|P-value:1.56E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.92|P-value:7.51E-7 ID:SGTC_2238|Compound:6671620|FD-Score:-3.34|P-value:4.93E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.16|P-value:9.27E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.39|P-value:4.11E-4 ID:SGTC_2343|Compound:7990716|FD-Score:4.36|P-value:1.05E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.49|P-value:3.30E-4 ID:SGTC_2411|Compound:st077133|FD-Score:3.24|P-value:7.88E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.32|P-value:6.02E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.52|P-value:2.65E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.41|P-value:3.89E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-5.08|P-value:2.89E-7 ID:SGTC_2835|Compound:9006588|FD-Score:-4.09|P-value:2.82E-5 ID:SGTC_2837|Compound:9008476|FD-Score:3.92|P-value:6.42E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-3.53|P-value:2.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-4.31|P-value:1.11E-5 ID:SGTC_3201|Compound:9113999|FD-Score:4.43|P-value:7.66E-6 ID:SGTC_3282|Compound:9108498|FD-Score:-3.49|P-value:2.95E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.40|P-value:4.03E-4 ID:SGTC_3296|Compound:9122258|FD-Score:7.24|P-value:7.23E-13

Top fitness defect scores for YGL166W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1741 st038134 7.68 10.2 µM 2.78E-14 3 7.73E-15
2 SGTC_3296 9122258 7.24 64.0 µM 7.23E-13 redox potentiating 4 2.30E-13
3 SGTC_2126 5251174 4.92 33.9 µM 7.51E-7 9 4.26E-7
4 SGTC_3201 9113999 4.43 49.5 µM 7.66E-6 23 4.79E-6
5 SGTC_2343 7990716 4.36 14.8 µM 1.05E-5 13 6.63E-6
6 SGTC_300 r073-0011 4.32 5.0 µM 1.22E-5 16 7.77E-6
7 SGTC_1375 2910-0797 4.23 186.0 µM 1.77E-5 20 1.14E-5
8 SGTC_1893 st059353 4.22 36.1 µM 1.85E-5 16 1.20E-5
9 SGTC_1887 st057648 4.18 70.8 µM 2.20E-5 9 1.44E-5
10 SGTC_1749 st037932 3.99 54.2 µM 4.86E-5 27 3.28E-5
11 SGTC_2837 9008476 3.92 45.5 µM 6.42E-5 36 4.39E-5
12 SGTC_2349 9023730 3.49 187.1 µM 3.30E-4 50 2.42E-4
13 SGTC_986 1493-0483 3.40 84.0 µM 4.56E-4 27 3.38E-4
14 SGTC_2492 derrusnin 3.32 100.0 µM 6.02E-4 13 4.52E-4
15 SGTC_1744 st037937 3.31 38.9 µM 6.22E-4 52 4.67E-4
16 SGTC_1743 st037606 3.24 46.4 µM 7.87E-4 47 5.97E-4
17 SGTC_2411 st077133 3.24 39.9 µM 7.88E-4 RNA pol III & RNase P/MRP 76 5.99E-4
18 SGTC_231 b-estradiol 3.23 524.0 µM 8.23E-4 22 6.26E-4
19 SGTC_2568 diosmetin 3.17 100.0 µM 0.00101 60 7.72E-4
20 SGTC_2340 7987427 3.13 183.4 µM 0.00115 72 8.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 3.79E-23 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.158 3.63E-20 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.150 2.88E-18 YBR199W KTR4 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
0.125 3.94E-13 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 5.87E-12 YOR202W HIS3 hom Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p
0.115 2.62E-11 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.114 3.86E-11 YFR057W_p YFR057W_p hom Putative protein of unknown function
0.112 8.58E-11 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.107 5.68E-10 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.107 6.14E-10 YBL001C ECM15 hom Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis
0.105 1.16E-9 YLR154C RNH203 hom Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome
0.103 1.94E-9 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
0.102 2.69E-9 YGL253W HXK2 hom Hexokinase isoenzyme 2; catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene; phosphorylation/dephosphorylation at serine-14 by protein kinase Snf1p and protein phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; HXK2 has a paralog, HXK1, that arose from the whole genome duplication
0.101 4.81E-9 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.094 4.53E-8 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins