HIPHOP chemogenomics database

YGL181W / GTS1

Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL181W / GTS1

Click on Significant Values for Screen Details

Top fitness defect scores for YGL181W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2072	5231554	5.82	129.0 µM	3.05E-9		1	2.99E-9
2	SGTC_2425	5628681	4.92	7.8 µM	4.35E-7		5	4.23E-7
3	SGTC_2287	7945887	4.87	168.8 µM	5.81E-7		3	5.65E-7
4	SGTC_1753	st043925	4.37	64.0 µM	6.43E-6		4	6.24E-6
5	SGTC_2081	5214970	3.88	32.3 µM	5.33E-5		27	5.16E-5
6	SGTC_2485	5633444	3.79	17.8 µM	7.76E-5	redox potentiating	51	7.52E-5
7	SGTC_1765	st044815	3.63	90.4 µM	1.45E-4		32	1.41E-4
8	SGTC_2436	5633522	3.57	8.1 µM	1.84E-4		27	1.78E-4
9	SGTC_1344	1488-0097	3.44	29.1 µM	2.96E-4		28	2.87E-4
10	SGTC_1625	st003711	3.36	30.1 µM	3.98E-4	calcium & mitochondrial duress	61	3.85E-4
11	SGTC_3145	9085516	3.35	49.5 µM	4.11E-4	fatty acid desaturase (OLE1)	50	3.98E-4
12	SGTC_2291	7917025	3.31	104.3 µM	4.78E-4	iron homeostasis	80	4.62E-4
13	SGTC_2582	agaric acid	3.25	100.0 µM	6.02E-4	redox potentiating	396	5.83E-4
14	SGTC_3141	9094609	3.24	49.5 µM	6.20E-4	iron homeostasis	64	6.00E-4
15	SGTC_2712	st079126	3.16	47.7 µM	8.03E-4		45	7.77E-4
16	SGTC_2942	9052777	3.02	62.2 µM	0.00129		81	0.00125
17	SGTC_392	N-ethylmaleimide	3.01	8.3 µM	0.00134	RNA pol III & RNase P/MRP	42	0.00130
18	SGTC_992	3909-8734	2.97	162.0 µM	0.00151		60	0.00147
19	SGTC_2762	leflunomide	2.97	42.1 µM	0.00154		80	0.00149
20	SGTC_2062	5245942	2.96	200.0 µM	0.00157		59	0.00152

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.195	4.91E-30	YGR097W	ASK10	hom	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.156	9.16E-20	YDR051C	DET1	hom	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.145	3.82E-17	YNL097C-B_p	YNL097C-B_p	hom	Putative protein of unknown function
0.144	6.11E-17	YLR414C	PUN1	hom	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.139	5.06E-16	YMR041C	ARA2	hom	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.138	1.06E-15	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136	2.31E-15	YBL028C	YBL028C	hom	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.133	9.93E-15	YML084W_d	YML084W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.128	9.97E-14	YDR244W	PEX5	hom	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions
0.123	9.76E-13	YEL040W	UTR2	hom	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.122	1.22E-12	YJL161W_p	FMP33_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.119	5.51E-12	YGR008C	STF2	hom	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.115	2.38E-11	YLR206W	ENT2	hom	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.113	5.63E-11	YDR252W	BTT1	hom	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.106	7.97E-10	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization