YGL197W / MDS3

Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL197W / MDS3

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:4.63E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.17|P-value:1.61E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:9.51E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.82|P-value:2.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.68|P-value:4.65E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.45|P-value:9.55E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.74|P-value:3.52E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.56|P-value:1.83E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.85|P-value:6.15E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.74|P-value:3.72E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:6.39|P-value:4.19E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:9.44E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-6.73|P-value:5.55E-10 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.52|P-value:7.25E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.15|P-value:1.76E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.75|P-value:9.48E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.51|P-value:7.97E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.24|P-value:6.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.72|P-value:1.06E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.88|P-value:2.37E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.47|P-value:8.96E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.43|P-value:9.30E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.60|P-value:5.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.51|P-value:7.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.86|P-value:2.55E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.65|P-value:5.07E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.71|P-value:1.09E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.44|P-value:9.75E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.01|P-value:1.49E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:9.61E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.76|P-value:1.03E-7 ID:SGTC_2349|Compound:9023730|FD-Score:-3.68|P-value:4.31E-4 ID:SGTC_2350|Compound:9023895|FD-Score:8.41|P-value:1.59E-14 ID:SGTC_2375|Compound:9072683|FD-Score:-3.95|P-value:1.76E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.82|P-value:2.71E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.78|P-value:3.33E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.25|P-value:6.35E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.81|P-value:2.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.92|P-value:1.91E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.66|P-value:4.65E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.62|P-value:5.27E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.49|P-value:7.83E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.97|P-value:1.62E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.76|P-value:3.53E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.74|P-value:3.52E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.13|P-value:1.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.76|P-value:3.31E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.76|P-value:3.25E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.57|P-value:6.16E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.51|P-value:7.94E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.61|P-value:5.34E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.74|P-value:3.76E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:4.63E-5 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.17|P-value:1.61E-6 ID:SGTC_154|Compound:3389-1638|FD-Score:3.45|P-value:9.51E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.82|P-value:2.89E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.68|P-value:4.65E-4 ID:SGTC_191|Compound:3914-0123|FD-Score:3.45|P-value:9.55E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-3.74|P-value:3.52E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-4.56|P-value:1.83E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:4.85|P-value:6.15E-6 ID:SGTC_344|Compound:k064-0035|FD-Score:3.74|P-value:3.72E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:6.39|P-value:4.19E-9 ID:SGTC_348|Compound:k064-0012|FD-Score:3.45|P-value:9.44E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-6.73|P-value:5.55E-10 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.52|P-value:7.25E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:5.15|P-value:1.76E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:4.75|P-value:9.48E-6 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.51|P-value:7.97E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.24|P-value:6.61E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_1730|Compound:st033808|FD-Score:4.72|P-value:1.06E-5 ID:SGTC_1734|Compound:st037168|FD-Score:3.88|P-value:2.37E-4 ID:SGTC_1772|Compound:st048439|FD-Score:3.47|P-value:8.96E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.75|P-value:3.68E-4 ID:SGTC_1798|Compound:st045719|FD-Score:4.11|P-value:1.06E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.43|P-value:9.30E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.60|P-value:5.85E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.51|P-value:7.78E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.86|P-value:2.55E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.65|P-value:5.07E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.71|P-value:1.09E-5 ID:SGTC_2160|Compound:5660466|FD-Score:3.44|P-value:9.75E-4 ID:SGTC_2198|Compound:6589944|FD-Score:4.01|P-value:1.49E-4 ID:SGTC_2285|Compound:7945142|FD-Score:3.44|P-value:9.61E-4 ID:SGTC_2340|Compound:7987427|FD-Score:5.76|P-value:1.03E-7 ID:SGTC_2349|Compound:9023730|FD-Score:-3.68|P-value:4.31E-4 ID:SGTC_2350|Compound:9023895|FD-Score:8.41|P-value:1.59E-14 ID:SGTC_2375|Compound:9072683|FD-Score:-3.95|P-value:1.76E-4 ID:SGTC_2385|Compound:9074692|FD-Score:-3.82|P-value:2.71E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.78|P-value:3.33E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:4.25|P-value:6.35E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:-3.81|P-value:2.75E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.92|P-value:1.91E-4 ID:SGTC_2703|Compound:st077852|FD-Score:-3.66|P-value:4.65E-4 ID:SGTC_2711|Compound:st079103|FD-Score:-3.62|P-value:5.27E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.49|P-value:7.83E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.97|P-value:1.62E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.76|P-value:3.53E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.74|P-value:3.52E-4 ID:SGTC_2926|Compound:9010726|FD-Score:4.13|P-value:1.00E-4 ID:SGTC_2998|Compound:9066762|FD-Score:-3.89|P-value:2.11E-4 ID:SGTC_3173|Compound:9105693|FD-Score:-3.76|P-value:3.31E-4 ID:SGTC_3180|Compound:9109287|FD-Score:-3.76|P-value:3.25E-4 ID:SGTC_3181|Compound:9108277|FD-Score:-3.57|P-value:6.16E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.51|P-value:7.94E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.61|P-value:5.34E-4 ID:SGTC_3339|Compound:9145883|FD-Score:3.74|P-value:3.76E-4

Top fitness defect scores for YGL197W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2350 9023895 8.41 38.9 µM 1.59E-14 ergosterol biosynthesis 3 1.97E-17
2 SGTC_346 4513-0042 6.39 7.2 µM 4.19E-9 azole & statin 7 8.40E-11
3 SGTC_2340 7987427 5.76 183.4 µM 1.03E-7 8 4.17E-9
4 SGTC_102 gallobenzophenone 5.17 83.6 µM 1.61E-6 redox potentiating 22 1.20E-7
5 SGTC_787 4152-0075 5.15 138.0 µM 1.76E-6 5 1.33E-7
6 SGTC_342 k048-0088 4.85 23.3 µM 6.15E-6 RSC & ERG11 6 6.14E-7
7 SGTC_827 3253-0474 4.75 693.0 µM 9.48E-6 8 1.04E-6
8 SGTC_1730 st033808 4.72 45.1 µM 1.06E-5 16 1.19E-6
9 SGTC_2128 5255449 4.71 168.5 µM 1.09E-5 16 1.23E-6
10 SGTC_2539 epi(13)torulosol 4.25 80.0 µM 6.35E-5 20 1.05E-5
11 SGTC_1387 3342-1166 4.24 1.8 µM 6.61E-5 mitochondrial processes 10 1.11E-5
12 SGTC_2926 9010726 4.13 65.2 µM 1.00E-4 29 1.84E-5
13 SGTC_1798 st045719 4.11 61.0 µM 1.06E-4 9 1.97E-5
14 SGTC_2198 6589944 4.01 200.0 µM 1.49E-4 19 2.98E-5
15 SGTC_1734 st037168 3.88 69.4 µM 2.37E-4 25 5.22E-5
16 SGTC_2052 5265182 3.86 7.1 µM 2.55E-4 36 5.72E-5
17 SGTC_163 1327-0036 3.82 7.5 µM 2.89E-4 114 6.65E-5
18 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.78 200.0 µM 3.33E-4 18 7.89E-5
19 SGTC_2884 9058502 3.76 52.0 µM 3.53E-4 33 8.48E-5
20 SGTC_1795 st049545 3.75 62.3 µM 3.68E-4 TSC3-RPN4 15 8.92E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.47E-9 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.084 1.18E-6 YPL209C IPL1 het Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest
0.080 3.12E-6 YBL056W PTC3 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication
0.080 3.85E-6 YHR114W BZZ1 hom SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
0.077 7.03E-6 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.076 1.10E-5 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.075 1.39E-5 YLR224W_p YLR224W_p hom F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
0.074 1.96E-5 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.073 2.38E-5 YNL205C_d YNL205C_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.073 2.44E-5 YNL009W IDP3 hom Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication
0.073 2.57E-5 YLR151C PCD1 hom Peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member
0.071 3.93E-5 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.071 3.94E-5 YJR039W_p YJR039W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.067 1.11E-4 YJR128W_d YJR128W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
0.066 1.20E-4 YOR172W YRM1 hom Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes