YGL208W / SIP2

One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL208W / SIP2

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:3.60|P-value:9.32E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.43|P-value:2.79E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.95|P-value:1.49E-7 ID:SGTC_433|Compound:pimozide|FD-Score:3.33|P-value:2.73E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.48|P-value:2.26E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.82|P-value:3.64E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.43|P-value:2.26E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.33|P-value:3.30E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.39|P-value:2.71E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:3.02|P-value:8.64E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.45|P-value:2.13E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.30|P-value:3.01E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.27|P-value:3.40E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.22|P-value:4.06E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.10|P-value:7.58E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.12|P-value:9.96E-6 ID:SGTC_1617|Compound:st002906|FD-Score:4.22|P-value:6.15E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.09|P-value:8.07E-4 ID:SGTC_1715|Compound:st032160|FD-Score:6.03|P-value:2.19E-10 ID:SGTC_1722|Compound:st034304|FD-Score:-4.07|P-value:1.56E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.51|P-value:1.64E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.19|P-value:4.68E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-5.12|P-value:7.58E-8 ID:SGTC_2366|Compound:9070441|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-4.53|P-value:1.74E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.22|P-value:3.26E-8 ID:SGTC_2468|Compound:5987765|FD-Score:3.99|P-value:1.77E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.89|P-value:2.74E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.82|P-value:4.60E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.27|P-value:4.21E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-3.19|P-value:5.64E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.08|P-value:8.41E-4 ID:SGTC_51|Compound:1013-0126|FD-Score:3.60|P-value:9.32E-5 ID:SGTC_282|Compound:k297-0036|FD-Score:-4.43|P-value:2.79E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:3.24|P-value:3.84E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:4.95|P-value:1.49E-7 ID:SGTC_433|Compound:pimozide|FD-Score:3.33|P-value:2.73E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.48|P-value:2.26E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:3.28|P-value:3.32E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:3.82|P-value:3.64E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.43|P-value:2.26E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.33|P-value:3.30E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:4.39|P-value:2.71E-6 ID:SGTC_890|Compound:0929-0006|FD-Score:3.02|P-value:8.64E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.57|P-value:1.08E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.04|P-value:7.93E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.45|P-value:2.13E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.30|P-value:3.01E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.27|P-value:3.40E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.08|P-value:6.84E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.22|P-value:4.06E-4 ID:SGTC_1437|Compound:4092-1038|FD-Score:-3.10|P-value:7.58E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.12|P-value:9.96E-6 ID:SGTC_1617|Compound:st002906|FD-Score:4.22|P-value:6.15E-6 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.09|P-value:8.07E-4 ID:SGTC_1715|Compound:st032160|FD-Score:6.03|P-value:2.19E-10 ID:SGTC_1722|Compound:st034304|FD-Score:-4.07|P-value:1.56E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.51|P-value:1.64E-4 ID:SGTC_2009|Compound:4012297|FD-Score:3.19|P-value:4.68E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.27|P-value:3.46E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-5.12|P-value:7.58E-8 ID:SGTC_2366|Compound:9070441|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_2376|Compound:9072922|FD-Score:-4.53|P-value:1.74E-6 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:5.22|P-value:3.26E-8 ID:SGTC_2468|Compound:5987765|FD-Score:3.99|P-value:1.77E-5 ID:SGTC_2718|Compound:lomofungin|FD-Score:3.89|P-value:2.74E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.82|P-value:4.60E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.27|P-value:4.21E-4 ID:SGTC_3242|Compound:9133940|FD-Score:-3.19|P-value:5.64E-4 ID:SGTC_3258|Compound:9138477|FD-Score:-3.08|P-value:8.41E-4

Top fitness defect scores for YGL208W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1715 st032160 6.03 10.2 µM 2.19E-10 16 8.11E-10
2 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 5.22 200.0 µM 3.26E-8 4 8.94E-8
3 SGTC_409 arachidonic acid 4.95 100.0 µM 1.49E-7 11 3.73E-7
4 SGTC_763 3453-1109 4.39 128.0 µM 2.71E-6 9 5.69E-6
5 SGTC_1617 st002906 4.22 78.0 µM 6.15E-6 21 1.23E-5
6 SGTC_1603 st002045 4.12 67.8 µM 9.96E-6 TSC3-RPN4 17 1.93E-5
7 SGTC_2468 5987765 3.99 72.9 µM 1.77E-5 13 3.33E-5
8 SGTC_2718 lomofungin 3.89 53.0 µM 2.74E-5 mitochondrial processes 10 5.01E-5
9 SGTC_612 0302-0167 3.82 22.4 µM 3.64E-5 copper-dependent oxidative stress 37 6.54E-5
10 SGTC_51 1013-0126 3.60 23.4 µM 9.32E-5 34 1.58E-4
11 SGTC_932 2857-0803 3.57 154.0 µM 1.08E-4 40 1.81E-4
12 SGTC_2366 9070441 3.47 60.6 µM 1.61E-4 50 2.64E-4
13 SGTC_433 pimozide 3.33 108.0 µM 2.73E-4 33 4.34E-4
14 SGTC_1203 3992-3522 3.30 103.0 µM 3.01E-4 66 4.76E-4
15 SGTC_601 0986-0029 3.28 62.9 µM 3.32E-4 calcium & mitochondrial duress 67 5.21E-4
16 SGTC_1244 0416-0015 3.27 52.5 µM 3.40E-4 ERG2 67 5.33E-4
17 SGTC_2341 7987486 3.27 176.7 µM 3.46E-4 40 5.42E-4
18 SGTC_361 000s-0510 3.24 1.4 µM 3.84E-4 62 5.98E-4
19 SGTC_1390 3413-2614 3.22 145.0 µM 4.06E-4 fatty acid desaturase (OLE1) 50 6.30E-4
20 SGTC_2009 4012297 3.19 12.1 µM 4.68E-4 cell wall signaling 100 7.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.45E-10 YMR316C-B_d YMR316C-B_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.106 6.41E-10 YOR354C MSC6 hom Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.106 7.31E-10 YGR207C CIR1 hom Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response
0.101 4.29E-9 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.100 7.94E-9 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.098 1.22E-8 YER046W SPO73 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
0.096 2.67E-8 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.090 1.83E-7 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.088 3.63E-7 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.085 8.19E-7 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.083 1.37E-6 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.082 1.97E-6 YLR419W_p YLR419W_p hom Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene
0.080 3.76E-6 YIL155C GUT2 hom Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
0.079 4.72E-6 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.079 4.93E-6 YBR264C YPT10 hom Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles