YGL213C / SKI8

Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL213C / SKI8

Click on Significant Values for Screen Details ID:SGTC_283|Compound:0987-0079|FD-Score:3.61|P-value:7.07E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-2.98|P-value:8.79E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.24|P-value:3.25E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.39|P-value:1.94E-6 ID:SGTC_433|Compound:pimozide|FD-Score:4.55|P-value:8.21E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.29|P-value:2.62E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:5.09|P-value:4.19E-8 ID:SGTC_595|Compound:3909-8003|FD-Score:3.12|P-value:5.00E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.00|P-value:8.20E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:1.08E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.08|P-value:6.03E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.71|P-value:3.45E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:4.74|P-value:2.98E-7 ID:SGTC_918|Compound:glabranin|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.04|P-value:1.07E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.69|P-value:5.11E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.18|P-value:2.47E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.39|P-value:1.77E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.04|P-value:1.09E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:3.85E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.63|P-value:6.62E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.62|P-value:6.98E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.56|P-value:8.93E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.66|P-value:5.90E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.33|P-value:2.25E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.33|P-value:2.28E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.60|P-value:7.75E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.86|P-value:2.45E-5 ID:SGTC_2484|Compound:5809818|FD-Score:5.39|P-value:6.94E-9 ID:SGTC_2488|Compound:5268135|FD-Score:-3.32|P-value:2.46E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.40|P-value:1.71E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.85|P-value:2.48E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.65|P-value:6.32E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.24|P-value:3.18E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.39|P-value:1.87E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.58|P-value:8.08E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.13|P-value:6.86E-6 ID:SGTC_3052|Compound:9092717|FD-Score:-3.03|P-value:7.47E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.74|P-value:4.32E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.67|P-value:5.58E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.23|P-value:3.42E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.87|P-value:2.39E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.51|P-value:1.01E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.38|P-value:1.94E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.24|P-value:3.26E-4 ID:SGTC_283|Compound:0987-0079|FD-Score:3.61|P-value:7.07E-5 ID:SGTC_298|Compound:1391-0729|FD-Score:-2.98|P-value:8.79E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.24|P-value:3.25E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:4.39|P-value:1.94E-6 ID:SGTC_433|Compound:pimozide|FD-Score:4.55|P-value:8.21E-7 ID:SGTC_538|Compound:2922-0838|FD-Score:3.29|P-value:2.62E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:5.09|P-value:4.19E-8 ID:SGTC_595|Compound:3909-8003|FD-Score:3.12|P-value:5.00E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.00|P-value:8.20E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:3.51|P-value:1.08E-4 ID:SGTC_634|Compound:1611-4317|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:-3.08|P-value:6.03E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:4.71|P-value:3.45E-7 ID:SGTC_831|Compound:k061-1017|FD-Score:4.74|P-value:2.98E-7 ID:SGTC_918|Compound:glabranin|FD-Score:3.08|P-value:5.88E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:4.04|P-value:1.07E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.69|P-value:5.11E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:5.18|P-value:2.47E-8 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.39|P-value:1.77E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:-4.04|P-value:1.09E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.12|P-value:5.09E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.96|P-value:1.54E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.76|P-value:3.85E-5 ID:SGTC_1712|Compound:st032288|FD-Score:-2.95|P-value:9.77E-4 ID:SGTC_1750|Compound:st081859|FD-Score:3.63|P-value:6.62E-5 ID:SGTC_1790|Compound:st045711|FD-Score:3.62|P-value:6.98E-5 ID:SGTC_1876|Compound:myriocin|FD-Score:3.56|P-value:8.93E-5 ID:SGTC_1989|Compound:st071868|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_2000|Compound:st075254|FD-Score:3.66|P-value:5.90E-5 ID:SGTC_2017|Compound:5132927|FD-Score:3.22|P-value:3.47E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.33|P-value:2.25E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_2148|Compound:5546263|FD-Score:3.33|P-value:2.28E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.49|P-value:1.25E-4 ID:SGTC_2268|Compound:7933382|FD-Score:-3.60|P-value:7.75E-5 ID:SGTC_2292|Compound:7671323|FD-Score:3.86|P-value:2.45E-5 ID:SGTC_2484|Compound:5809818|FD-Score:5.39|P-value:6.94E-9 ID:SGTC_2488|Compound:5268135|FD-Score:-3.32|P-value:2.46E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.40|P-value:1.71E-4 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.85|P-value:2.48E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:-3.65|P-value:6.32E-5 ID:SGTC_2885|Compound:9057732|FD-Score:3.24|P-value:3.18E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.39|P-value:1.87E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.58|P-value:8.08E-5 ID:SGTC_2920|Compound:7982904|FD-Score:-3.33|P-value:2.36E-4 ID:SGTC_3011|Compound:9081274|FD-Score:4.13|P-value:6.86E-6 ID:SGTC_3052|Compound:9092717|FD-Score:-3.03|P-value:7.47E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.74|P-value:4.32E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.67|P-value:5.58E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.23|P-value:3.42E-4 ID:SGTC_3174|Compound:9107204|FD-Score:-3.87|P-value:2.39E-5 ID:SGTC_3178|Compound:9107506|FD-Score:4.51|P-value:1.01E-6 ID:SGTC_3179|Compound:9107801|FD-Score:-3.38|P-value:1.94E-4 ID:SGTC_3222|Compound:9128301|FD-Score:3.24|P-value:3.26E-4

Top fitness defect scores for YGL213C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2484 5809818 5.39 12.0 µM 6.94E-9 5 3.51E-8
2 SGTC_1137 ixabepilone 5.18 100.0 µM 2.47E-8 10 1.11E-7
3 SGTC_558 k064-0027 5.09 21.3 µM 4.19E-8 DNA damage response 12 1.79E-7
4 SGTC_831 k061-1017 4.74 217.0 µM 2.98E-7 translation 27 1.06E-6
5 SGTC_726 3448-4391 4.71 34.2 µM 3.45E-7 2 1.21E-6
6 SGTC_433 pimozide 4.55 108.0 µM 8.21E-7 10 2.66E-6
7 SGTC_3178 9107506 4.51 49.5 µM 1.01E-6 7 3.21E-6
8 SGTC_378 3970-0959 4.39 8.3 µM 1.94E-6 12 5.80E-6
9 SGTC_3011 9081274 4.13 71.4 µM 6.86E-6 12 1.82E-5
10 SGTC_1081 sertraline 4.04 6.0 µM 1.07E-5 60S ribosome export 33 2.72E-5
11 SGTC_1591 genipin 3.96 88.4 µM 1.54E-5 mitochondrial processes 13 3.80E-5
12 SGTC_2292 7671323 3.86 168.1 µM 2.45E-5 RNA processing & uracil transport 35 5.77E-5
13 SGTC_2721 ifenprodil 3.85 61.4 µM 2.48E-5 plasma membrane duress 22 5.85E-5
14 SGTC_1135 dihydrocapsaicin 3.69 536.7 nM 5.11E-5 45 1.13E-4
15 SGTC_3059 1327-0034 3.67 3.0 µM 5.58E-5 62 1.22E-4
16 SGTC_2000 st075254 3.66 36.4 µM 5.90E-5 11 1.28E-4
17 SGTC_1750 st081859 3.63 2.4 µM 6.62E-5 endomembrane recycling 212 1.42E-4
18 SGTC_1790 st045711 3.62 43.5 µM 6.98E-5 19 1.50E-4
19 SGTC_283 0987-0079 3.61 11.7 µM 7.07E-5 38 1.51E-4
20 SGTC_2897 9048598 3.58 13.0 µM 8.08E-5 24 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.88E-12 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.120 2.46E-12 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.108 3.65E-10 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.089 2.74E-7 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.087 3.95E-7 YPR153W YPR153W hom Putative protein of unknown function
0.079 4.09E-6 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.077 8.95E-6 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.076 9.19E-6 YKR103W NFT1 hom Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
0.075 1.30E-5 YLR363C NMD4 hom Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.074 1.78E-5 YGL102C_d YGL102C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
0.071 3.47E-5 YPL102C_d YPL102C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4
0.071 3.64E-5 YKL098W MTC2 hom Protein of unknown function; mtc2 is synthetically sick with cdc13-1
0.071 3.87E-5 YLR226W BUR2 hom Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II
0.069 5.74E-5 YML072C TCB3 hom Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.069 6.70E-5 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity