Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGL218W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.325 | 2.30E-83 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.319 | 7.33E-80 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.316 | 1.63E-78 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.315 | 4.21E-78 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.301 | 4.26E-71 | YGR101W | PCP1 | hom | Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases |
0.298 | 9.34E-70 | YMR064W | AEP1 | hom | Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase |
0.297 | 2.43E-69 | YDR268W | MSW1 | hom | Mitochondrial tryptophanyl-tRNA synthetase |
0.295 | 2.03E-68 | YDR298C | ATP5 | hom | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated |
0.293 | 1.70E-67 | YER028C | MIG3 | hom | Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication |
0.291 | 2.89E-66 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.290 | 6.48E-66 | YER087W | AIM10 | hom | Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
0.288 | 3.74E-65 | YLR091W | GEP5 | hom | Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine |
0.288 | 5.67E-65 | YLL033W | IRC19 | hom | Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
0.288 | 7.50E-65 | YLR149C | YLR149C | hom | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |
0.283 | 1.21E-62 | YHR168W | MTG2 | hom | Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly |