YGL222C / EDC1

RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL222C / EDC1

Click on Significant Values for Screen Details ID:SGTC_145|Compound:3737-0113|FD-Score:3.46|P-value:1.61E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.73|P-value:5.24E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:2.99|P-value:9.30E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.98|P-value:1.70E-5 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.35|P-value:3.05E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.53|P-value:1.22E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.79|P-value:3.26E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.79|P-value:3.97E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.00|P-value:8.90E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.00|P-value:9.08E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.03|P-value:8.15E-8 ID:SGTC_831|Compound:k061-1017|FD-Score:3.41|P-value:1.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.05|P-value:7.56E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:15.20|P-value:2.30E-56 ID:SGTC_998|Compound:3996-0085|FD-Score:3.71|P-value:5.75E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.05|P-value:7.39E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.53|P-value:1.24E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.94|P-value:2.06E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.20|P-value:6.31E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.11|P-value:6.17E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.24|P-value:3.76E-4 ID:SGTC_1706|Compound:st031321|FD-Score:2.99|P-value:9.37E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.65|P-value:6.70E-7 ID:SGTC_2338|Compound:7999974|FD-Score:4.27|P-value:4.51E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.46|P-value:1.61E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.44|P-value:7.73E-9 ID:SGTC_2686|Compound:alizarin|FD-Score:3.04|P-value:7.77E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.41|P-value:1.94E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.66|P-value:7.01E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.24|P-value:3.78E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.60|P-value:9.24E-5 ID:SGTC_3326|Compound:9140064|FD-Score:5.26|P-value:2.27E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:3.46|P-value:1.61E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.73|P-value:5.24E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:2.99|P-value:9.30E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:2.98|P-value:9.77E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.98|P-value:1.70E-5 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.52|P-value:1.25E-4 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:-4.35|P-value:3.05E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:-3.53|P-value:1.22E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-4.79|P-value:3.26E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.79|P-value:3.97E-5 ID:SGTC_761|Compound:k216-0224|FD-Score:3.00|P-value:8.90E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.00|P-value:9.08E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.03|P-value:8.15E-8 ID:SGTC_831|Compound:k061-1017|FD-Score:3.41|P-value:1.96E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.05|P-value:7.56E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:15.20|P-value:2.30E-56 ID:SGTC_998|Compound:3996-0085|FD-Score:3.71|P-value:5.75E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:5.05|P-value:7.39E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:-4.53|P-value:1.24E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.94|P-value:2.06E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-4.20|P-value:6.31E-6 ID:SGTC_1232|Compound:0279-0259|FD-Score:-3.27|P-value:3.36E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.11|P-value:6.17E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.24|P-value:3.76E-4 ID:SGTC_1706|Compound:st031321|FD-Score:2.99|P-value:9.37E-4 ID:SGTC_2305|Compound:7443522|FD-Score:4.65|P-value:6.70E-7 ID:SGTC_2338|Compound:7999974|FD-Score:4.27|P-value:4.51E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.46|P-value:1.61E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.21|P-value:4.18E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:5.44|P-value:7.73E-9 ID:SGTC_2686|Compound:alizarin|FD-Score:3.04|P-value:7.77E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.41|P-value:1.94E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.66|P-value:7.01E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.24|P-value:3.78E-4 ID:SGTC_3325|Compound:9138760|FD-Score:-3.60|P-value:9.24E-5 ID:SGTC_3326|Compound:9140064|FD-Score:5.26|P-value:2.27E-8

Top fitness defect scores for YGL222C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 15.20 1.8 µM 2.30E-56 5 2.96E-52
2 SGTC_2616 abietic acid 5.44 100.0 µM 7.73E-9 13 2.72E-8
3 SGTC_3326 9140064 5.26 16.4 µM 2.27E-8 9 7.38E-8
4 SGTC_1132 3456-3614 5.05 2.5 µM 7.39E-8 tubulin folding & SWR complex 17 2.20E-7
5 SGTC_829 1635-0120 5.03 117.0 µM 8.15E-8 DNA damage response 19 2.41E-7
6 SGTC_2305 7443522 4.65 69.2 µM 6.70E-7 6 1.70E-6
7 SGTC_2338 7999974 4.27 200.0 µM 4.51E-6 13 9.94E-6
8 SGTC_405 ebelactone b 3.98 50.0 µM 1.70E-5 17 3.39E-5
9 SGTC_1178 0988-0033 3.94 191.0 µM 2.06E-5 26 4.06E-5
10 SGTC_669 0108-0021 3.79 26.2 µM 3.97E-5 fatty acid desaturase (OLE1) 88 7.47E-5
11 SGTC_358 0075-0058 3.73 9.4 µM 5.24E-5 71 9.67E-5
12 SGTC_998 3996-0085 3.71 177.0 µM 5.75E-5 28 1.05E-4
13 SGTC_2899 9053889 3.66 58.4 µM 7.01E-5 15 1.27E-4
14 SGTC_473 2-arachidonoylglycerol 3.52 10.0 µM 1.25E-4 28 2.16E-4
15 SGTC_145 3737-0113 3.46 38.4 µM 1.61E-4 DNA intercalators 99 2.74E-4
16 SGTC_2693 st077581 3.41 40.7 µM 1.94E-4 61 3.25E-4
17 SGTC_831 k061-1017 3.41 217.0 µM 1.96E-4 translation 95 3.28E-4
18 SGTC_1587 estradiol valerate 3.24 56.1 µM 3.76E-4 36 6.02E-4
19 SGTC_2977 9011197 3.24 71.4 µM 3.78E-4 33 6.06E-4
20 SGTC_2514 salinomycin 3.21 42.7 µM 4.15E-4 93 6.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.541 9.54E-255 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.407 5.40E-134 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.403 2.04E-131 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.398 3.94E-127 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.359 1.58E-102 YDL177C_p YDL177C_p hom Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene
0.348 6.21E-96 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.331 3.16E-86 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.330 4.84E-86 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.307 4.14E-74 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.302 7.97E-72 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.301 3.70E-71 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.288 5.76E-65 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.286 3.82E-64 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.283 5.95E-63 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.264 1.32E-54 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C