YGL231C / EMC4

Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4, fly CG11137, human TMM85

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL231C / EMC4

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:4.86|P-value:3.88E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.78|P-value:5.67E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.39|P-value:9.19E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:4.09|P-value:8.65E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.53|P-value:2.07E-12 ID:SGTC_640|Compound:3381-0960|FD-Score:4.64|P-value:1.01E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.76|P-value:2.78E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.34|P-value:9.65E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.35|P-value:9.52E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-4.11|P-value:6.95E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.38|P-value:9.56E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.54|P-value:1.49E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.67|P-value:3.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.39|P-value:2.74E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.08|P-value:7.96E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.43|P-value:8.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.27|P-value:4.04E-9 ID:SGTC_1943|Compound:st076331|FD-Score:5.12|P-value:1.24E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-3.89|P-value:1.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.45|P-value:7.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.36|P-value:9.06E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.37|P-value:8.79E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.54|P-value:5.08E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.43|P-value:7.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-9.02|P-value:3.73E-17 ID:SGTC_2808|Compound:7946468|FD-Score:-4.09|P-value:7.69E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.59|P-value:4.88E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.49|P-value:6.70E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.56|P-value:1.38E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-3.95|P-value:1.24E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.20|P-value:5.03E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.04|P-value:1.02E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.86|P-value:3.88E-6 ID:SGTC_152|Compound:4469-0003|FD-Score:3.58|P-value:5.02E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.78|P-value:5.67E-6 ID:SGTC_315|Compound:k915-0449|FD-Score:3.39|P-value:9.19E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:4.09|P-value:8.65E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:7.53|P-value:2.07E-12 ID:SGTC_640|Compound:3381-0960|FD-Score:4.64|P-value:1.01E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.76|P-value:2.78E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:-3.34|P-value:9.65E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.35|P-value:9.52E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-4.11|P-value:6.95E-5 ID:SGTC_1085|Compound:doxorubicin|FD-Score:3.93|P-value:1.52E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.38|P-value:9.56E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:4.54|P-value:1.49E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.67|P-value:3.81E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.39|P-value:2.74E-5 ID:SGTC_1632|Compound:st005650|FD-Score:3.77|P-value:2.65E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-4.08|P-value:7.96E-5 ID:SGTC_1651|Compound:st011928|FD-Score:3.43|P-value:8.32E-4 ID:SGTC_1750|Compound:st081859|FD-Score:6.27|P-value:4.04E-9 ID:SGTC_1943|Compound:st076331|FD-Score:5.12|P-value:1.24E-6 ID:SGTC_1950|Compound:st077106|FD-Score:-3.89|P-value:1.58E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.45|P-value:7.62E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.36|P-value:9.06E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.37|P-value:8.79E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.54|P-value:5.08E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.43|P-value:7.40E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.86|P-value:1.97E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.96|P-value:1.37E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-9.02|P-value:3.73E-17 ID:SGTC_2808|Compound:7946468|FD-Score:-4.09|P-value:7.69E-5 ID:SGTC_2813|Compound:7971799|FD-Score:3.59|P-value:4.88E-4 ID:SGTC_3022|Compound:9087993|FD-Score:3.49|P-value:6.70E-4 ID:SGTC_3025|Compound:9087895|FD-Score:4.56|P-value:1.38E-5 ID:SGTC_3133|Compound:9127736|FD-Score:-3.95|P-value:1.24E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.20|P-value:5.03E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.04|P-value:1.02E-4

Top fitness defect scores for YGL231C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 7.53 112.0 µM 2.07E-12 ERG2 20 2.51E-14
2 SGTC_1750 st081859 6.27 2.4 µM 4.04E-9 endomembrane recycling 102 1.83E-10
3 SGTC_1943 st076331 5.12 65.2 µM 1.24E-6 4 1.51E-7
4 SGTC_59 0330-0160 4.86 1.3 µM 3.88E-6 63 5.74E-7
5 SGTC_163 1327-0036 4.78 7.5 µM 5.67E-6 73 8.95E-7
6 SGTC_640 3381-0960 4.64 37.1 µM 1.01E-5 4 1.77E-6
7 SGTC_3025 9087895 4.56 49.5 µM 1.38E-5 PDR1 29 2.54E-6
8 SGTC_1287 0971-0001 4.54 34.6 µM 1.49E-5 sphingolipid biosynthesis & PDR1 35 2.78E-6
9 SGTC_1628 st004252 4.39 77.7 µM 2.74E-5 13 5.68E-6
10 SGTC_438 sphingosine 4.09 6.7 µM 8.65E-5 18 2.18E-5
11 SGTC_3145 9085516 4.04 49.5 µM 1.02E-4 fatty acid desaturase (OLE1) 25 2.62E-5
12 SGTC_2762 leflunomide 3.96 42.1 µM 1.37E-4 28 3.73E-5
13 SGTC_1085 doxorubicin 3.93 7.7 µM 1.52E-4 anthracycline transcription coupled DNA repair 19 4.20E-5
14 SGTC_2752 diclazuril 3.86 33.1 µM 1.97E-4 124 5.70E-5
15 SGTC_1632 st005650 3.77 90.0 µM 2.65E-4 35 8.05E-5
16 SGTC_662 k832-1615 3.76 104.0 µM 2.78E-4 21 8.51E-5
17 SGTC_1391 3442-0225 3.67 151.0 µM 3.81E-4 22 1.23E-4
18 SGTC_743 1275-0778 3.62 158.0 µM 4.51E-4 excess fatty acid 46 1.50E-4
19 SGTC_2813 7971799 3.59 71.4 µM 4.88E-4 27 1.64E-4
20 SGTC_152 4469-0003 3.58 551.2 µM 5.02E-4 31 1.70E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 3.47E-43 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.227 1.66E-40 YKL207W EMC3 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111
0.213 1.22E-35 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.205 3.85E-33 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.197 1.53E-30 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.189 3.21E-28 YLL014W EMC6 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93
0.172 1.25E-23 YCL046W_d YCL046W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C
0.159 2.07E-20 YCL045C EMC1 hom Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090
0.150 2.30E-18 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.145 2.62E-17 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.145 3.18E-17 YPR153W YPR153W hom Putative protein of unknown function
0.144 4.46E-17 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.144 5.60E-17 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.139 6.42E-16 YPL077C_p YPL077C_p hom Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication
0.136 3.07E-15 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling