YGL248W / PDE1

Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL248W / PDE1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.18|P-value:3.71E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.06|P-value:8.60E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.02|P-value:7.10E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.88|P-value:2.01E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.04|P-value:6.35E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-2.99|P-value:7.93E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.00|P-value:7.65E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.11|P-value:4.92E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.17|P-value:3.98E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.19|P-value:3.74E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.96|P-value:8.76E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.29|P-value:2.89E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.11|P-value:4.96E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.06|P-value:6.00E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.03|P-value:6.86E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-2.97|P-value:8.53E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.41|P-value:1.57E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-2.92|P-value:9.99E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.22|P-value:3.97E-6 ID:SGTC_1571|Compound:st070080|FD-Score:-3.13|P-value:4.65E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.35|P-value:1.95E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-2.94|P-value:9.28E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.84|P-value:2.35E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.21|P-value:3.34E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.97|P-value:8.24E-4 ID:SGTC_1992|Compound:st073643|FD-Score:2.93|P-value:9.41E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-5.52|P-value:2.59E-9 ID:SGTC_2056|Compound:5235370|FD-Score:-3.46|P-value:1.25E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_2237|Compound:6667747|FD-Score:6.74|P-value:4.78E-13 ID:SGTC_2241|Compound:6772625|FD-Score:-5.27|P-value:1.21E-8 ID:SGTC_2309|Compound:7664088|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.44|P-value:1.29E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.97|P-value:1.26E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.23|P-value:3.14E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.95|P-value:8.87E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.30|P-value:2.32E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.36|P-value:1.85E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.64|P-value:5.82E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-2.96|P-value:8.86E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.26|P-value:2.79E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.20|P-value:3.62E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.08|P-value:5.57E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.01|P-value:7.04E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.30|P-value:2.43E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.55|P-value:6.96E-7 ID:SGTC_3279|Compound:9140807|FD-Score:-3.56|P-value:8.30E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.87|P-value:2.16E-5 ID:SGTC_3308|Compound:9128332|FD-Score:2.97|P-value:8.25E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.97|P-value:8.13E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.18|P-value:3.71E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.06|P-value:8.60E-6 ID:SGTC_117|Compound:lucigenin|FD-Score:-3.02|P-value:7.10E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.88|P-value:2.01E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.51|P-value:1.01E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.04|P-value:6.35E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-2.99|P-value:7.93E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:-3.00|P-value:7.65E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:3.11|P-value:4.92E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.17|P-value:3.98E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-3.19|P-value:3.74E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.96|P-value:8.76E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-4.29|P-value:2.89E-6 ID:SGTC_522|Compound:1273-0010|FD-Score:3.30|P-value:2.36E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.32|P-value:2.18E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:3.11|P-value:4.96E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.06|P-value:6.00E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:-3.03|P-value:6.86E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-2.97|P-value:8.53E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:-3.41|P-value:1.57E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-2.92|P-value:9.99E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.22|P-value:3.97E-6 ID:SGTC_1571|Compound:st070080|FD-Score:-3.13|P-value:4.65E-4 ID:SGTC_1591|Compound:genipin|FD-Score:3.35|P-value:1.95E-4 ID:SGTC_1647|Compound:st011722|FD-Score:-2.94|P-value:9.28E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.84|P-value:2.35E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.21|P-value:3.34E-4 ID:SGTC_1979|Compound:st071809|FD-Score:2.97|P-value:8.24E-4 ID:SGTC_1992|Compound:st073643|FD-Score:2.93|P-value:9.41E-4 ID:SGTC_2028|Compound:5153890|FD-Score:-5.52|P-value:2.59E-9 ID:SGTC_2056|Compound:5235370|FD-Score:-3.46|P-value:1.25E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.31|P-value:2.21E-4 ID:SGTC_2237|Compound:6667747|FD-Score:6.74|P-value:4.78E-13 ID:SGTC_2241|Compound:6772625|FD-Score:-5.27|P-value:1.21E-8 ID:SGTC_2309|Compound:7664088|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-3.42|P-value:1.49E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:4.44|P-value:1.29E-6 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.97|P-value:1.26E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-3.23|P-value:3.14E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.95|P-value:8.87E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:3.22|P-value:3.16E-4 ID:SGTC_2709|Compound:st078560|FD-Score:-3.30|P-value:2.45E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.30|P-value:2.32E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.36|P-value:1.85E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.64|P-value:5.82E-5 ID:SGTC_2835|Compound:9006588|FD-Score:-2.96|P-value:8.86E-4 ID:SGTC_2837|Compound:9008476|FD-Score:3.26|P-value:2.79E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.20|P-value:3.62E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.36|P-value:1.81E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-3.08|P-value:5.57E-4 ID:SGTC_3262|Compound:9137218|FD-Score:3.01|P-value:7.04E-4 ID:SGTC_3272|Compound:9137413|FD-Score:-3.30|P-value:2.43E-4 ID:SGTC_3278|Compound:9139605|FD-Score:4.55|P-value:6.96E-7 ID:SGTC_3279|Compound:9140807|FD-Score:-3.56|P-value:8.30E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-3.87|P-value:2.16E-5 ID:SGTC_3308|Compound:9128332|FD-Score:2.97|P-value:8.25E-4 ID:SGTC_3323|Compound:9138564|FD-Score:2.97|P-value:8.13E-4

Top fitness defect scores for YGL248W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2237 6667747 6.74 47.2 µM 4.78E-13 2 8.10E-12
2 SGTC_3278 9139605 4.55 49.5 µM 6.96E-7 4 2.63E-6
3 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 4.44 54.6 µM 1.29E-6 RPP1 & pyrimidine depletion 21 4.56E-6
4 SGTC_1564 D-Arginine 4.22 115.0 µM 3.97E-6 21 1.25E-5
5 SGTC_108 0509-0257 4.06 621.1 µM 8.60E-6 49 2.50E-5
6 SGTC_2598 perillyl alcohol 3.97 100.0 µM 1.26E-5 32 3.52E-5
7 SGTC_1654 st012436 3.84 41.8 µM 2.35E-5 17 6.14E-5
8 SGTC_147 4466-0538 3.51 29.2 µM 1.01E-4 ergosterol biosynthesis 37 2.28E-4
9 SGTC_2309 7664088 3.50 163.9 µM 1.04E-4 62 2.34E-4
10 SGTC_3098 9119039 3.36 49.5 µM 1.81E-4 Golgi 55 3.83E-4
11 SGTC_2769 toremifene 3.36 3.7 µM 1.85E-4 42 3.92E-4
12 SGTC_1591 genipin 3.35 88.4 µM 1.95E-4 mitochondrial processes 29 4.10E-4
13 SGTC_747 3448-8087 3.32 38.7 µM 2.18E-4 52 4.52E-4
14 SGTC_2166 5933061 3.31 31.5 µM 2.21E-4 tubulin folding & SWR complex 63 4.60E-4
15 SGTC_2764 methyldopa 3.30 94.7 µM 2.32E-4 40 4.78E-4
16 SGTC_522 1273-0010 3.30 11.6 µM 2.36E-4 60S ribosome export 44 4.86E-4
17 SGTC_2837 9008476 3.26 45.5 µM 2.79E-4 65 5.66E-4
18 SGTC_2635 hydroquinidine 3.22 100.0 µM 3.16E-4 43 6.33E-4
19 SGTC_1784 st039334 3.21 36.3 µM 3.34E-4 42 6.64E-4
20 SGTC_11 0438-0307 3.18 1.3 µM 3.71E-4 28 7.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.17E-12 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.111 1.11E-10 YNL057W_d YNL057W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.110 1.64E-10 YIL007C NAS2 hom Proteasome-interacting protein; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress
0.101 4.27E-9 YOL060C MAM3 hom Protein required for normal mitochondrial morphology, has similarity to hemolysins
0.100 6.13E-9 YDL016C_d YDL016C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication
0.094 4.37E-8 YOL091W SPO21 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.091 1.47E-7 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.088 3.08E-7 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.088 3.63E-7 YMR112C MED11 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
0.087 4.84E-7 YIR013C GAT4 hom Protein containing GATA family zinc finger motifs
0.082 1.94E-6 YLR282C_d YLR282C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
0.082 2.08E-6 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.14E-6 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.079 4.20E-6 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.079 4.71E-6 YFL044C OTU1 hom Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress