YGL257C / MNT2

Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL257C / MNT2

Click on Significant Values for Screen Details ID:SGTC_71|Compound:0417-1750|FD-Score:3.73|P-value:7.22E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.36|P-value:2.71E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:3.22E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.66|P-value:9.87E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.68|P-value:9.02E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.20|P-value:5.61E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.78|P-value:5.32E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.24|P-value:7.60E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.22|P-value:7.18E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.27|P-value:3.72E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:1.36E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.41|P-value:2.57E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.22|P-value:4.56E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.76|P-value:6.34E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.68|P-value:8.76E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.77|P-value:6.19E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.01|P-value:9.52E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.31|P-value:5.61E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.80|P-value:5.54E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.30|P-value:3.91E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.85|P-value:3.87E-7 ID:SGTC_2920|Compound:7982904|FD-Score:-3.67|P-value:7.94E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.17|P-value:6.28E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.05|P-value:8.23E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:3.73|P-value:7.22E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.36|P-value:2.71E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.31|P-value:3.22E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.66|P-value:9.87E-5 ID:SGTC_344|Compound:k064-0035|FD-Score:3.68|P-value:9.02E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.64|P-value:1.05E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.20|P-value:5.61E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:4.78|P-value:5.32E-7 ID:SGTC_1070|Compound:indatraline|FD-Score:4.24|P-value:7.60E-6 ID:SGTC_1125|Compound:tnp00248|FD-Score:-4.22|P-value:7.18E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:3.18|P-value:6.12E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:-3.27|P-value:3.72E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.57|P-value:1.36E-4 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.20|P-value:4.84E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:-3.30|P-value:3.39E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.41|P-value:2.57E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.09|P-value:8.42E-4 ID:SGTC_1733|Compound:st037357|FD-Score:3.50|P-value:1.82E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.22|P-value:4.56E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.76|P-value:6.34E-5 ID:SGTC_2062|Compound:5245942|FD-Score:3.58|P-value:1.35E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.20|P-value:5.62E-4 ID:SGTC_2242|Compound:6630449|FD-Score:3.68|P-value:8.76E-5 ID:SGTC_2297|Compound:7971671|FD-Score:3.77|P-value:6.19E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.01|P-value:9.52E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:4.31|P-value:5.61E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:3.80|P-value:5.54E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.09|P-value:8.32E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.48|P-value:2.00E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.30|P-value:3.91E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.85|P-value:3.87E-7 ID:SGTC_2920|Compound:7982904|FD-Score:-3.67|P-value:7.94E-5 ID:SGTC_3109|Compound:9122853|FD-Score:3.17|P-value:6.28E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.05|P-value:8.23E-4

Top fitness defect scores for YGL257C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2757 clomiphene 4.85 4.2 µM 3.87E-7 fatty acid desaturase (OLE1) 22 6.30E-7
2 SGTC_1068 loratadine 4.78 26.9 µM 5.32E-7 13 8.55E-7
3 SGTC_2540 epiandrosterone 4.31 100.0 µM 5.61E-6 46 8.20E-6
4 SGTC_1070 indatraline 4.24 8.8 µM 7.60E-6 60S ribosome export 21 1.10E-5
5 SGTC_2557 derrustone 3.80 83.8 µM 5.54E-5 42 7.38E-5
6 SGTC_2297 7971671 3.77 152.3 µM 6.19E-5 RNA processing & uracil transport 33 8.22E-5
7 SGTC_2051 5263410 3.76 176.0 µM 6.34E-5 19 8.41E-5
8 SGTC_71 0417-1750 3.73 47.8 µM 7.22E-5 Golgi 52 9.52E-5
9 SGTC_2242 6630449 3.68 61.3 µM 8.76E-5 Golgi 51 1.15E-4
10 SGTC_344 k064-0035 3.68 6.4 µM 9.02E-5 60S ribosome export 27 1.18E-4
11 SGTC_76 0433-0009 3.66 400.3 µM 9.87E-5 20 1.29E-4
12 SGTC_866 0495-0101 3.64 262.0 µM 1.05E-4 60S ribosome export 28 1.37E-4
13 SGTC_2062 5245942 3.58 200.0 µM 1.35E-4 31 1.74E-4
14 SGTC_1409 3909-8004 3.57 61.9 µM 1.36E-4 27 1.75E-4
15 SGTC_1733 st037357 3.50 54.9 µM 1.82E-4 60S ribosome export 52 2.31E-4
16 SGTC_2569 tetrandrine 3.48 100.0 µM 2.00E-4 36 2.53E-4
17 SGTC_1628 st004252 3.41 77.7 µM 2.57E-4 38 3.23E-4
18 SGTC_2683 piperine 3.30 63.0 µM 3.91E-4 30 4.83E-4
19 SGTC_1413 3910-0535 3.27 34.4 µM 4.33E-4 31 5.33E-4
20 SGTC_1057 3448-5381 3.20 134.0 µM 5.61E-4 calcium & mitochondrial duress 51 6.83E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.42E-11 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.112 7.03E-11 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.111 1.17E-10 YLR406C-A_p YLR406C-A_p hom Putative protein of unknown function
0.108 3.66E-10 YDR223W CRF1 hom Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain
0.106 7.66E-10 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.104 1.34E-9 YCL041C_d YCL041C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W
0.103 2.14E-9 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.102 3.48E-9 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.102 3.48E-9 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.095 3.54E-8 YLR173W_p YLR173W_p hom Putative protein of unknown function
0.094 4.31E-8 YLR307W CDA1 hom Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.093 6.93E-8 YDR390C UBA2 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.093 7.36E-8 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.091 1.13E-7 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.085 7.36E-7 YDR524C AGE1 hom ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif