YGL263W / COS12

Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL263W / COS12

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.13|P-value:1.71E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.75|P-value:8.37E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:4.16|P-value:9.85E-7 ID:SGTC_641|Compound:4092-0595|FD-Score:-2.97|P-value:3.36E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.95|P-value:3.66E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.03|P-value:2.10E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.18|P-value:1.37E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.36|P-value:6.03E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.70|P-value:9.92E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.47|P-value:3.65E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.15|P-value:1.57E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.72|P-value:9.49E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.73|P-value:9.00E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:2.85|P-value:5.68E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.90|P-value:4.58E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.96|P-value:3.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:2.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.72|P-value:9.15E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.99|P-value:3.21E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.80|P-value:6.69E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-2.93|P-value:4.00E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-4.62|P-value:6.15E-8 ID:SGTC_2301|Compound:7769476|FD-Score:4.70|P-value:3.77E-8 ID:SGTC_2316|Compound:5844804|FD-Score:3.80|P-value:7.13E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.14|P-value:1.67E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.71|P-value:3.57E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.27|P-value:8.94E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.73|P-value:8.79E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-2.78|P-value:7.28E-4 ID:SGTC_2812|Compound:7970281|FD-Score:2.86|P-value:5.35E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.43|P-value:4.31E-5 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:1.31E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.13|P-value:1.71E-4 ID:SGTC_394|Compound:menadione|FD-Score:2.75|P-value:8.37E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:4.16|P-value:9.85E-7 ID:SGTC_641|Compound:4092-0595|FD-Score:-2.97|P-value:3.36E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:-2.95|P-value:3.66E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:4.03|P-value:2.10E-6 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.18|P-value:1.37E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.36|P-value:6.03E-5 ID:SGTC_1096|Compound:rimcazole|FD-Score:-2.70|P-value:9.92E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.47|P-value:3.65E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.15|P-value:1.57E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:2.72|P-value:9.49E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:2.73|P-value:9.00E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:2.85|P-value:5.68E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:2.90|P-value:4.58E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:2.96|P-value:3.55E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.07|P-value:2.20E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-2.72|P-value:9.15E-4 ID:SGTC_1924|Compound:st058459|FD-Score:2.99|P-value:3.21E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.80|P-value:6.69E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-2.93|P-value:4.00E-4 ID:SGTC_2298|Compound:7976326|FD-Score:-4.62|P-value:6.15E-8 ID:SGTC_2301|Compound:7769476|FD-Score:4.70|P-value:3.77E-8 ID:SGTC_2316|Compound:5844804|FD-Score:3.80|P-value:7.13E-6 ID:SGTC_2537|Compound:larixol|FD-Score:3.14|P-value:1.67E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.71|P-value:3.57E-8 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.27|P-value:8.94E-5 ID:SGTC_2600|Compound:tangeritin|FD-Score:-2.73|P-value:8.79E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-2.78|P-value:7.28E-4 ID:SGTC_2812|Compound:7970281|FD-Score:2.86|P-value:5.35E-4 ID:SGTC_2817|Compound:7995342|FD-Score:-3.43|P-value:4.31E-5 ID:SGTC_2898|Compound:9056270|FD-Score:3.20|P-value:1.31E-4

Top fitness defect scores for YGL263W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 4.71 100.0 µM 3.57E-8 14 1.22E-6
2 SGTC_2301 7769476 4.70 200.0 µM 3.77E-8 15 1.27E-6
3 SGTC_438 sphingosine 4.16 6.7 µM 9.85E-7 16 1.58E-5
4 SGTC_1009 4106-0057 4.03 9.9 µM 2.10E-6 10 2.84E-5
5 SGTC_2316 5844804 3.80 197.4 µM 7.13E-6 38 7.31E-5
6 SGTC_1100 amiodarone 3.47 5.1 µM 3.65E-5 28 2.59E-4
7 SGTC_1024 4507-0395 3.36 26.0 µM 6.03E-5 TSC3-RPN4 43 3.83E-4
8 SGTC_2898 9056270 3.20 58.4 µM 1.31E-4 16 6.99E-4
9 SGTC_1014 4130-3005 3.18 69.3 µM 1.37E-4 54 7.25E-4
10 SGTC_2537 larixol 3.14 68.9 µM 1.67E-4 62 8.46E-4
11 SGTC_1924 st058459 2.99 75.1 µM 3.21E-4 42 0.00141
12 SGTC_1374 2889-5571 2.96 141.0 µM 3.55E-4 RSC complex & mRNA processing 96 0.00152
13 SGTC_1323 1348-1351 2.90 11.2 µM 4.58E-4 46 0.00186
14 SGTC_2812 7970281 2.86 58.4 µM 5.35E-4 95 0.00209
15 SGTC_1266 0828-0227 2.85 32.9 µM 5.68E-4 69 0.00219
16 SGTC_394 menadione 2.75 8.3 µM 8.37E-4 superoxide 92 0.00297
17 SGTC_1209 2323-2347 2.73 50.3 µM 9.00E-4 56 0.00314
18 SGTC_1135 dihydrocapsaicin 2.72 536.7 nM 9.49E-4 114 0.00328
19 SGTC_2839 9003951 2.67 26.0 µM 0.00114 62 0.00378
20 SGTC_1321 1326-2144 2.67 215.0 µM 0.00114 71 0.00379

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.235 3.88E-43 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.183 1.05E-26 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.179 1.33E-25 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.177 7.07E-25 YKL106C-A_p YKL106C-A_p hom Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi
0.160 1.52E-20 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.129 5.60E-14 YOL125W TRM13 hom 2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
0.124 4.92E-13 YGL201C MCM6 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p
0.124 6.29E-13 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.118 8.57E-12 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.116 1.47E-11 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.110 1.71E-10 YGL109W_d YGL109W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C
0.110 1.80E-10 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.108 4.13E-10 YLR227C ADY4 hom Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
0.107 5.20E-10 YEL010W_d YEL010W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 1.97E-9 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W