YGR001C_p

Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR001C / YGR001C

Click on Significant Values for Screen Details ID:SGTC_326|Compound:k292-0812|FD-Score:2.80|P-value:9.86E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.10|P-value:3.11E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:2.93|P-value:5.96E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:2.95|P-value:5.52E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.91|P-value:8.06E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.56|P-value:5.61E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.62|P-value:1.79E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-2.91|P-value:8.05E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.39|P-value:1.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.00|P-value:5.75E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.02|P-value:6.35E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.85|P-value:1.07E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.52|P-value:5.20E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.47|P-value:1.25E-9 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.87|P-value:9.22E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.28|P-value:1.86E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.92|P-value:1.04E-5 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:2.96|P-value:5.26E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.44|P-value:9.20E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.30|P-value:1.46E-6 ID:SGTC_1790|Compound:st045711|FD-Score:4.88|P-value:3.74E-8 ID:SGTC_1909|Compound:st060837|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.97|P-value:2.60E-11 ID:SGTC_1987|Compound:st072290|FD-Score:3.70|P-value:2.20E-5 ID:SGTC_2372|Compound:9071633|FD-Score:2.94|P-value:5.69E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.82|P-value:9.16E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-2.97|P-value:6.38E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.03|P-value:4.39E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.33|P-value:1.50E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.59|P-value:4.88E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.12|P-value:3.51E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.17|P-value:2.92E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.00|P-value:5.80E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-8.88|P-value:1.59E-22 ID:SGTC_3208|Compound:9114115|FD-Score:4.32|P-value:9.55E-7 ID:SGTC_3209|Compound:9113616|FD-Score:4.21|P-value:1.70E-6 ID:SGTC_326|Compound:k292-0812|FD-Score:2.80|P-value:9.86E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.10|P-value:3.11E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:2.93|P-value:5.96E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:2.95|P-value:5.52E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-2.91|P-value:8.06E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:-3.56|P-value:5.61E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.62|P-value:1.79E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:3.20|P-value:2.01E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:-2.91|P-value:8.05E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.39|P-value:1.16E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.00|P-value:5.75E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:-4.02|P-value:6.35E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.85|P-value:1.07E-5 ID:SGTC_1089|Compound:terbinafine|FD-Score:3.52|P-value:5.20E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-5.47|P-value:1.25E-9 ID:SGTC_1218|Compound:1348-1416|FD-Score:-2.87|P-value:9.22E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:-3.28|P-value:1.86E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.92|P-value:1.04E-5 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:2.96|P-value:5.26E-4 ID:SGTC_1676|Compound:st018489|FD-Score:-3.44|P-value:9.20E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.30|P-value:1.46E-6 ID:SGTC_1790|Compound:st045711|FD-Score:4.88|P-value:3.74E-8 ID:SGTC_1909|Compound:st060837|FD-Score:3.10|P-value:3.10E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.97|P-value:2.60E-11 ID:SGTC_1987|Compound:st072290|FD-Score:3.70|P-value:2.20E-5 ID:SGTC_2372|Compound:9071633|FD-Score:2.94|P-value:5.69E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.82|P-value:9.16E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-2.97|P-value:6.38E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.09|P-value:3.18E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.03|P-value:4.39E-6 ID:SGTC_2830|Compound:7992007|FD-Score:-3.33|P-value:1.50E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-3.59|P-value:4.88E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.12|P-value:3.51E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-4.17|P-value:2.92E-6 ID:SGTC_3205|Compound:9113483|FD-Score:-3.00|P-value:5.80E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-8.88|P-value:1.59E-22 ID:SGTC_3208|Compound:9114115|FD-Score:4.32|P-value:9.55E-7 ID:SGTC_3209|Compound:9113616|FD-Score:4.21|P-value:1.70E-6

Top fitness defect scores for YGR001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1913 st060213 5.97 96.1 µM 2.60E-11 5 1.22E-9
2 SGTC_1790 st045711 4.88 43.5 µM 3.74E-8 6 5.21E-7
3 SGTC_769 0302-0231 4.62 76.0 µM 1.79E-7 22 1.92E-6
4 SGTC_3208 9114115 4.32 49.5 µM 9.55E-7 27 7.79E-6
5 SGTC_3209 9113616 4.21 49.5 µM 1.70E-6 20 1.26E-5
6 SGTC_411 enrofloxacin 4.10 100.0 µM 3.11E-6 DNA damage response 11 2.09E-5
7 SGTC_2678 equilin 4.03 100.0 µM 4.39E-6 22 2.78E-5
8 SGTC_1087 pterostilbene 3.85 9.1 µM 1.07E-5 29 5.86E-5
9 SGTC_1987 st072290 3.70 61.9 µM 2.20E-5 19 1.07E-4
10 SGTC_1089 terbinafine 3.52 2.2 µM 5.20E-5 27 2.20E-4
11 SGTC_869 0564-0080 3.20 44.1 µM 2.01E-4 46 6.82E-4
12 SGTC_1909 st060837 3.10 51.5 µM 3.10E-4 89 9.79E-4
13 SGTC_2634 4'-methoxyflavone 3.09 100.0 µM 3.18E-4 74 0.00100
14 SGTC_1420 4'-methoxyflavone 2.96 42.0 µM 5.26E-4 43 0.00152
15 SGTC_616 4092-0450 2.95 108.0 µM 5.52E-4 52 0.00159
16 SGTC_2372 9071633 2.94 200.0 µM 5.69E-4 46 0.00163
17 SGTC_505 gw-5074 2.93 63.9 µM 5.96E-4 101 0.00169
18 SGTC_2374 9071832 2.82 200.0 µM 9.16E-4 endomembrane recycling 44 0.00243
19 SGTC_326 k292-0812 2.80 17.5 µM 9.86E-4 39 0.00258
20 SGTC_1085 doxorubicin 2.78 7.7 µM 0.00104 anthracycline transcription coupled DNA repair 85 0.00270

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.55E-25 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.168 1.21E-22 YHL016C DUR3 hom Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
0.158 4.69E-20 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.141 1.91E-16 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.138 9.18E-16 YLR199C PBA1 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.127 1.57E-13 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.123 7.67E-13 YOL082W ATG19 hom Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles
0.121 2.04E-12 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.118 6.65E-12 YLR343W GAS2 hom 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
0.117 1.35E-11 YDR339C FCF1 het Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p
0.115 2.49E-11 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.113 5.49E-11 YJR002W MPP10 het Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
0.110 1.93E-10 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.108 4.22E-10 YER044C-A MEI4 hom Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores
0.107 5.74E-10 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA