YGR012W

Putative cysteine synthase, localized to the mitochondrial outer membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR012W / YGR012W

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.29|P-value:8.84E-9 ID:SGTC_38|Compound:0929-0051|FD-Score:-5.77|P-value:4.15E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.77|P-value:3.05E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.42|P-value:1.29E-6 ID:SGTC_269|Compound:exalamide|FD-Score:-4.03|P-value:9.09E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.06|P-value:5.55E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.04|P-value:4.02E-8 ID:SGTC_963|Compound:1269-2853|FD-Score:6.60|P-value:1.03E-12 ID:SGTC_966|Compound:1300-0360|FD-Score:4.61|P-value:4.48E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.91|P-value:9.77E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.01|P-value:6.68E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.14|P-value:4.10E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.97|P-value:1.17E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.63|P-value:5.61E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.04|P-value:6.11E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.02|P-value:6.56E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.06|P-value:5.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.24|P-value:2.83E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:2.95|P-value:8.52E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.07|P-value:7.35E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.08|P-value:5.21E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.29|P-value:8.84E-9 ID:SGTC_38|Compound:0929-0051|FD-Score:-5.77|P-value:4.15E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.77|P-value:3.05E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.42|P-value:1.29E-6 ID:SGTC_269|Compound:exalamide|FD-Score:-4.03|P-value:9.09E-6 ID:SGTC_533|Compound:1222-0222|FD-Score:3.06|P-value:5.55E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:5.04|P-value:4.02E-8 ID:SGTC_963|Compound:1269-2853|FD-Score:6.60|P-value:1.03E-12 ID:SGTC_966|Compound:1300-0360|FD-Score:4.61|P-value:4.48E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:2.91|P-value:9.77E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:3.05|P-value:5.89E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.01|P-value:6.68E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.26|P-value:2.61E-4 ID:SGTC_1776|Compound:st049249|FD-Score:-3.14|P-value:4.10E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.97|P-value:1.17E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.09|P-value:4.96E-4 ID:SGTC_1906|Compound:st060206|FD-Score:3.63|P-value:5.61E-5 ID:SGTC_1967|Compound:st070177|FD-Score:3.04|P-value:6.11E-4 ID:SGTC_2032|Compound:5185112|FD-Score:-3.02|P-value:6.56E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.06|P-value:5.73E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.24|P-value:2.83E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.01|P-value:6.63E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:2.95|P-value:8.52E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.07|P-value:7.35E-6 ID:SGTC_2957|Compound:9076800|FD-Score:3.16|P-value:3.84E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.08|P-value:5.21E-4

Top fitness defect scores for YGR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_963 1269-2853 6.60 151.0 µM 1.03E-12 3 2.03E-11
2 SGTC_35 0133-0054 5.29 64.1 µM 8.84E-9 7 6.13E-8
3 SGTC_962 1254-0300 5.04 21.5 µM 4.02E-8 11 2.35E-7
4 SGTC_966 1300-0360 4.61 30.2 µM 4.48E-7 heme requiring 13 1.98E-6
5 SGTC_2917 7979103 4.07 53.8 µM 7.35E-6 27 2.37E-5
6 SGTC_1906 st060206 3.63 94.7 µM 5.61E-5 25 1.44E-4
7 SGTC_1572 epiandrosterone 3.26 68.9 µM 2.61E-4 52 5.63E-4
8 SGTC_2260 7964312 3.24 200.0 µM 2.83E-4 35 6.04E-4
9 SGTC_2957 9076800 3.16 11.5 µM 3.84E-4 45 7.93E-4
10 SGTC_1844 rapamycin 3.09 4.0 nM 4.96E-4 230 9.96E-4
11 SGTC_3154 9100113 3.08 49.5 µM 5.21E-4 68 0.00104
12 SGTC_533 1222-0222 3.06 6.7 µM 5.55E-4 PDR1 66 0.00110
13 SGTC_1301 naphtanilide LB 3.05 4.8 µM 5.89E-4 heme requiring 37 0.00116
14 SGTC_1967 st070177 3.04 51.4 µM 6.11E-4 55 0.00120
15 SGTC_2303 7774051 3.01 200.0 µM 6.63E-4 54 0.00129
16 SGTC_1563 conessine 3.01 56.1 µM 6.68E-4 51 0.00130
17 SGTC_2409 alverine citrate 2.95 64.0 µM 8.52E-4 116 0.00161
18 SGTC_1262 0737-0114 2.91 49.6 µM 9.77E-4 73 0.00182
19 SGTC_3160 9100216 2.88 49.5 µM 0.00107 29 0.00197
20 SGTC_1785 bathophenanthroline 2.85 24.0 µM 0.00119 heme requiring 115 0.00216

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.30E-21 YMR004W MVP1 hom Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress
0.162 3.03E-21 YGL151W NUT1 hom Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
0.161 5.81E-21 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.146 1.69E-17 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.140 4.44E-16 YNR056C BIO5 hom Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis
0.130 4.11E-14 YIR025W MND2 hom Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase
0.128 1.19E-13 YLR357W RSC2 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
0.125 3.65E-13 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.118 7.66E-12 YAR035C-A_p YAR035C-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis
0.117 1.17E-11 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.115 2.45E-11 YGR042W YGR042W hom Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress
0.115 2.85E-11 YHR097C_p YHR097C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
0.114 3.35E-11 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.111 1.20E-10 YDR179W-A_p YDR179W-A_p hom Putative protein of unknown function
0.109 2.40E-10 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication