YGR019W / UGA1

Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR019W / UGA1

Click on Significant Values for Screen Details ID:SGTC_178|Compound:4092-0806|FD-Score:-3.00|P-value:6.87E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.04|P-value:6.20E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.12|P-value:4.46E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.68|P-value:4.44E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.96|P-value:6.26E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:5.12|P-value:2.51E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.98|P-value:7.54E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.99|P-value:7.33E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.84|P-value:2.20E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:1.92E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:7.12E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.40|P-value:1.46E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.74|P-value:3.53E-5 ID:SGTC_1703|Compound:st026983|FD-Score:4.40|P-value:1.43E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.20|P-value:3.87E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-2.93|P-value:8.87E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.01|P-value:6.73E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.95|P-value:8.19E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.64|P-value:5.30E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.46|P-value:1.14E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.64|P-value:5.32E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.48|P-value:1.06E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.22|P-value:2.95E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.23|P-value:2.98E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.50|P-value:8.58E-7 ID:SGTC_2404|Compound:5161160|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.54|P-value:8.28E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.64|P-value:3.73E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.02|P-value:6.29E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.24|P-value:2.72E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.08|P-value:6.97E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.94|P-value:8.48E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.18|P-value:3.54E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.24|P-value:2.82E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:3.44E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.00|P-value:6.87E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.31|P-value:2.16E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.04|P-value:6.20E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.12|P-value:4.46E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:-3.68|P-value:4.44E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:-4.96|P-value:6.26E-8 ID:SGTC_996|Compound:3970-0799|FD-Score:5.12|P-value:2.51E-8 ID:SGTC_1126|Compound:isoteolin|FD-Score:-2.98|P-value:7.54E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:2.99|P-value:7.33E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.84|P-value:2.20E-5 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:1.92E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.07|P-value:7.12E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.40|P-value:1.46E-4 ID:SGTC_1688|Compound:st021091|FD-Score:3.74|P-value:3.53E-5 ID:SGTC_1703|Compound:st026983|FD-Score:4.40|P-value:1.43E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.20|P-value:3.87E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-2.93|P-value:8.87E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.01|P-value:6.73E-4 ID:SGTC_2087|Compound:5276107|FD-Score:-2.95|P-value:8.19E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.47|P-value:1.10E-4 ID:SGTC_2119|Compound:5528445|FD-Score:-3.64|P-value:5.30E-5 ID:SGTC_2159|Compound:5658611|FD-Score:3.20|P-value:3.35E-4 ID:SGTC_2162|Compound:5663267|FD-Score:3.46|P-value:1.14E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.64|P-value:5.32E-5 ID:SGTC_2284|Compound:7945075|FD-Score:3.38|P-value:1.64E-4 ID:SGTC_2297|Compound:7971671|FD-Score:3.48|P-value:1.06E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.22|P-value:2.95E-4 ID:SGTC_2316|Compound:5844804|FD-Score:3.23|P-value:2.98E-4 ID:SGTC_2395|Compound:5646831|FD-Score:4.50|P-value:8.58E-7 ID:SGTC_2404|Compound:5161160|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.44|P-value:1.26E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.54|P-value:8.28E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:-4.64|P-value:3.73E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.36|P-value:1.67E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.02|P-value:6.29E-4 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:-3.24|P-value:2.72E-4 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.08|P-value:6.97E-6 ID:SGTC_2815|Compound:7968870|FD-Score:-2.94|P-value:8.48E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.05|P-value:5.80E-4 ID:SGTC_3042|Compound:9091578|FD-Score:3.18|P-value:3.54E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.24|P-value:2.82E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.18|P-value:3.44E-4

Top fitness defect scores for YGR019W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 5.12 1.8 µM 2.51E-8 50 1.52E-7
2 SGTC_2395 5646831 4.50 180.2 µM 8.58E-7 16 3.46E-6
3 SGTC_1703 st026983 4.40 48.3 µM 1.43E-6 5 5.45E-6
4 SGTC_1375 2910-0797 3.84 186.0 µM 2.20E-5 27 6.15E-5
5 SGTC_1688 st021091 3.74 57.6 µM 3.53E-5 8 9.36E-5
6 SGTC_2281 7943571 3.64 200.0 µM 5.32E-5 16 1.35E-4
7 SGTC_2514 salinomycin 3.54 42.7 µM 8.28E-5 70 2.00E-4
8 SGTC_2297 7971671 3.48 152.3 µM 1.06E-4 RNA processing & uracil transport 45 2.49E-4
9 SGTC_2106 5357045 3.47 167.3 µM 1.10E-4 31 2.57E-4
10 SGTC_2162 5663267 3.46 200.0 µM 1.14E-4 21 2.66E-4
11 SGTC_2468 5987765 3.44 72.9 µM 1.26E-4 32 2.90E-4
12 SGTC_2284 7945075 3.38 39.2 µM 1.64E-4 mitochondrial processes 48 3.66E-4
13 SGTC_1378 2093-0007 3.34 380.0 nM 1.92E-4 43 4.23E-4
14 SGTC_638 3970-0837 3.31 4.1 µM 2.16E-4 69 4.69E-4
15 SGTC_3080 9117754 3.24 49.5 µM 2.82E-4 44 5.94E-4
16 SGTC_2316 5844804 3.23 197.4 µM 2.98E-4 73 6.24E-4
17 SGTC_2159 5658611 3.20 73.8 µM 3.35E-4 21 6.93E-4
18 SGTC_3042 9091578 3.18 49.5 µM 3.54E-4 ERG2 16 7.27E-4
19 SGTC_2404 5161160 3.09 200.0 µM 5.06E-4 57 0.00100
20 SGTC_2978 9011784 3.05 43.0 µM 5.80E-4 79 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.230 1.65E-41 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.219 1.17E-37 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.212 2.86E-35 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.182 2.85E-26 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.180 7.50E-26 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.179 1.94E-25 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress
0.174 3.59E-24 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.163 2.31E-21 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.154 2.61E-19 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.151 1.87E-18 YKL010C UFD4 hom Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress
0.145 2.70E-17 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.144 4.38E-17 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.143 9.62E-17 YDL086W_p YDL086W_p hom Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene
0.143 1.06E-16 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.141 1.77E-16 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication