HIPHOP chemogenomics database

YGR035W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR035W-A / YGR035W-A

Click on Significant Values for Screen Details

Top fitness defect scores for YGR035W-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_3210	9128157	9.03	49.5 µM	1.50E-22		3	8.75E-20
2	SGTC_1851	st056236	6.56	18.9 µM	8.93E-13		1	2.73E-11
3	SGTC_2752	diclazuril	5.04	33.1 µM	3.02E-8		75	2.38E-7
4	SGTC_1592	4',5'-dihydroxyflavone	4.96	8.8 µM	4.88E-8	60S ribosome export	2	3.61E-7
5	SGTC_2638	epoxomicin	4.94	18.0 µM	5.29E-8		12	3.87E-7
6	SGTC_236	1509-0011	4.65	5.3 µM	2.83E-7		347	1.67E-6
7	SGTC_2712	st079126	4.63	47.7 µM	3.14E-7		6	1.82E-6
8	SGTC_2955	9076254	4.47	12.2 µM	7.72E-7		9	3.99E-6
9	SGTC_1523	st012844	4.26	44.7 µM	2.23E-6	60S ribosome export	12	1.01E-5
10	SGTC_2919	7978188	4.12	46.4 µM	4.67E-6		15	1.92E-5
11	SGTC_2354	9060492	3.88	162.0 µM	1.47E-5		20	5.22E-5
12	SGTC_779	1360-0071	3.88	233.0 µM	1.50E-5	fatty acid desaturase (OLE1)	26	5.29E-5
13	SGTC_771	0250-0039	3.85	27.3 µM	1.72E-5		16	5.99E-5
14	SGTC_2375	9072683	3.80	200.0 µM	2.12E-5	mitochondrial processes	23	7.18E-5
15	SGTC_1720	st037298	3.79	9.5 µM	2.25E-5		36	7.56E-5
16	SGTC_769	0302-0231	3.70	76.0 µM	3.43E-5		50	1.09E-4
17	SGTC_2355	9061122	3.67	103.1 µM	3.80E-5		16	1.19E-4
18	SGTC_1589	2',5'-dimethoxyflavone	3.61	47.2 µM	5.10E-5		29	1.54E-4
19	SGTC_2126	5251174	3.58	33.9 µM	5.89E-5		54	1.75E-4
20	SGTC_2820	7989630	3.57	71.4 µM	6.06E-5	ERG2	36	1.79E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.136	2.64E-15	YBR052C	RFS1	hom	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication
0.133	8.68E-15	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.128	1.24E-13	YLL006W-A_p	YLL006W-A_p	hom	Putative protein of unknown function; identified by fungal homology and RT-PCR
0.124	5.44E-13	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.123	9.61E-13	YER141W	COX15	hom	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.123	1.06E-12	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.121	2.07E-12	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.121	2.21E-12	YOR161C-C_p	YOR161C-C_p	hom	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.120	2.57E-12	YJL127C-B_p	YJL127C-B_p	hom	Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
0.120	2.53E-12	YLL017W	YLL017W	hom	Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.120	2.95E-12	YPR159C-A_p	YPR159C-A_p	hom	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.118	5.81E-12	YKL109W	HAP4	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.118	8.31E-12	YLL033W	IRC19	hom	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.117	9.06E-12	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.117	9.29E-12	YLR361C-A_p	YLR361C-A_p	hom	Putative protein of unknown function