Correlation | pval | ORF | Gene | Zygosity | Description |
---|
0.136 |
2.64E-15 |
YBR052C |
RFS1 |
hom |
Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication |
0.133 |
8.68E-15 |
YHR050W-A_p |
YHR050W-A_p |
hom |
Protein of unknown function; identified by expression profiling and mass spectrometry |
0.128 |
1.24E-13 |
YLL006W-A_p |
YLL006W-A_p |
hom |
Putative protein of unknown function; identified by fungal homology and RT-PCR |
0.124 |
5.44E-13 |
YOR330C |
MIP1 |
hom |
Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit |
0.123 |
9.61E-13 |
YER141W |
COX15 |
hom |
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
0.123 |
1.06E-12 |
YGL237C |
HAP2 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding |
0.121 |
2.07E-12 |
YJL166W |
QCR8 |
hom |
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
0.121 |
2.21E-12 |
YOR161C-C_p |
YOR161C-C_p |
hom |
Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
0.120 |
2.57E-12 |
YJL127C-B_p |
YJL127C-B_p |
hom |
Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii |
0.120 |
2.53E-12 |
YLL017W |
YLL017W |
hom |
Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication |
0.120 |
2.95E-12 |
YPR159C-A_p |
YPR159C-A_p |
hom |
Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
0.118 |
5.81E-12 |
YKL109W |
HAP4 |
hom |
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex |
0.118 |
8.31E-12 |
YLL033W |
IRC19 |
hom |
Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci |
0.117 |
9.06E-12 |
YOR065W |
CYT1 |
hom |
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex |
0.117 |
9.29E-12 |
YLR361C-A_p |
YLR361C-A_p |
hom |
Putative protein of unknown function |