YGR041W / BUD9

Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR041W / BUD9

Click on Significant Values for Screen Details ID:SGTC_248|Compound:streptozotocin|FD-Score:2.90|P-value:4.40E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.74|P-value:2.61E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:4.64E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.93|P-value:3.71E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.72|P-value:8.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.69|P-value:9.68E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.51|P-value:2.87E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.84|P-value:5.34E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.00|P-value:2.92E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.14|P-value:1.60E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.97|P-value:3.06E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.93|P-value:3.69E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.19|P-value:1.17E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.59|P-value:1.78E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.47|P-value:3.16E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-2.99|P-value:2.88E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.31|P-value:7.38E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.76|P-value:7.49E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.32|P-value:3.24E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.95|P-value:3.63E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.74|P-value:7.87E-4 ID:SGTC_2707|Compound:st078556|FD-Score:2.78|P-value:7.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.06|P-value:2.13E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.29|P-value:7.30E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-2.79|P-value:6.44E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.85|P-value:5.11E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.52|P-value:9.65E-8 ID:SGTC_248|Compound:streptozotocin|FD-Score:2.90|P-value:4.40E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:4.74|P-value:2.61E-8 ID:SGTC_367|Compound:0335-0881|FD-Score:3.41|P-value:4.64E-5 ID:SGTC_380|Compound:3970-0968|FD-Score:-2.93|P-value:3.71E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-2.72|P-value:8.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:-2.69|P-value:9.68E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.51|P-value:2.87E-5 ID:SGTC_952|Compound:1185-0122|FD-Score:-2.84|P-value:5.34E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:3.00|P-value:2.92E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.14|P-value:1.60E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-2.97|P-value:3.06E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.93|P-value:3.69E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.19|P-value:1.17E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:-3.59|P-value:1.78E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:-3.47|P-value:3.16E-5 ID:SGTC_2117|Compound:5521686|FD-Score:-2.99|P-value:2.88E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.31|P-value:7.38E-5 ID:SGTC_2431|Compound:5490079|FD-Score:-3.76|P-value:7.49E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.32|P-value:3.24E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:2.95|P-value:3.63E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-2.74|P-value:7.87E-4 ID:SGTC_2707|Compound:st078556|FD-Score:2.78|P-value:7.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:-3.06|P-value:2.13E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.29|P-value:7.30E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-2.79|P-value:6.44E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-2.85|P-value:5.11E-4 ID:SGTC_3082|Compound:9117008|FD-Score:-3.09|P-value:1.82E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-4.52|P-value:9.65E-8

Top fitness defect scores for YGR041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_292 k038-0015 4.74 474.0 µM 2.61E-8 1 1.06E-6
2 SGTC_944 3370-0224 3.51 231.0 µM 2.87E-5 40 2.27E-4
3 SGTC_367 0335-0881 3.41 7.1 µM 4.64E-5 ubiquinone biosynthesis & proteasome 106 3.29E-4
4 SGTC_2372 9071633 3.31 200.0 µM 7.38E-5 27 4.70E-4
5 SGTC_996 3970-0799 3.14 1.8 µM 1.60E-4 144 8.54E-4
6 SGTC_988 1497-1057 3.00 103.0 µM 2.92E-4 43 0.00136
7 SGTC_2622 2-methoxyxanthone 2.95 59.9 µM 3.63E-4 60 0.00161
8 SGTC_248 streptozotocin 2.90 5.2 mM 4.40E-4 DNA damage response 62 0.00187
9 SGTC_2707 st078556 2.78 66.6 µM 7.21E-4 54 0.00273
10 SGTC_1089 terbinafine 2.66 2.2 µM 0.00113 88 0.00387
11 SGTC_1946 st076057 2.58 65.1 µM 0.00155 48 0.00496
12 SGTC_3084 9116877 2.51 49.5 µM 0.00200 51 0.00603
13 SGTC_2050 5263056 2.50 171.0 µM 0.00205 fatty acid desaturase (OLE1) 155 0.00614
14 SGTC_3151 9099821 2.50 49.5 µM 0.00206 118 0.00616
15 SGTC_1219 1469-0211 2.48 33.1 µM 0.00222 85 0.00654
16 SGTC_418 lividomycin a 2.46 100.0 µM 0.00236 100 0.00686
17 SGTC_152 4469-0003 2.44 551.2 µM 0.00262 100 0.00743
18 SGTC_775 4577-0580 2.43 57.3 µM 0.00270 96 0.00761
19 SGTC_774 k060-0086 2.42 136.0 µM 0.00279 140 0.00781
20 SGTC_2755 lomerizine 2.38 42.7 µM 0.00322 150 0.00872

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.211 4.84E-35 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.195 5.56E-30 YHR188C GPI16 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
0.168 1.09E-22 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.168 1.23E-22 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.167 2.10E-22 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.149 5.27E-18 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.145 3.01E-17 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.141 2.68E-16 YHR040W BCD1 het Essential protein required for the accumulation of box C/D snoRNA
0.141 2.88E-16 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.134 7.04E-15 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.129 6.29E-14 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.128 1.16E-13 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.126 2.07E-13 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.119 4.22E-12 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.118 8.39E-12 YNR033W ABZ1 hom Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress