Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress

Zygosity: Homozygous strain
Profile for YGR042W / YGR042W

Click on Significant Values for Screen Details

Top fitness defect scores for YGR042W deletion by condition

RankScreen IDConditionFD ScoreConc
1 SGTC_2926 9010726 5.24 65.2 µM 1.58E-9 12 7.96E-8
2 SGTC_2002 4023503 5.14 131.0 µM 3.21E-9 mitochondrial processes 11 1.39E-7
3 SGTC_2480 5767542 5.04 37.2 µM 6.17E-9 4 2.33E-7
4 SGTC_2917 7979103 4.82 53.8 µM 2.64E-8 13 7.33E-7
5 SGTC_2925 9010536 4.74 32.5 µM 4.34E-8 azole & statin 27 1.08E-6
6 SGTC_1289 0976-0073 4.61 69.1 µM 9.39E-8 6 1.99E-6
7 SGTC_2482 5981709 3.76 142.7 µM 1.09E-5 PDR1 43 8.52E-5
8 SGTC_2479 5617353 3.74 43.9 µM 1.19E-5 46 9.12E-5
9 SGTC_963 1269-2853 3.70 151.0 µM 1.47E-5 32 1.08E-4
10 SGTC_1213 1315-0166 3.68 115.0 µM 1.65E-5 38 1.18E-4
11 SGTC_2487 5918373 3.57 44.0 µM 2.72E-5 24 1.76E-4
12 SGTC_2316 5844804 3.54 197.4 µM 3.20E-5 53 2.00E-4
13 SGTC_2918 7977171 3.41 22.1 µM 5.93E-5 44 3.26E-4
14 SGTC_504 lovastatin 3.41 124.0 µM 5.94E-5 26 3.26E-4
15 SGTC_1283 0922-0125 3.39 16.4 µM 6.50E-5 42 3.50E-4
16 SGTC_898 1000-0849 3.29 28.3 µM 1.02E-4 17 5.02E-4
17 SGTC_1141 3253-0389 3.14 52.6 µM 1.94E-4 24 8.33E-4
18 SGTC_533 1222-0222 3.03 6.7 µM 3.13E-4 PDR1 69 0.00122
19 SGTC_1356 1502-0781 3.01 85.8 µM 3.35E-4 fatty acid desaturase (OLE1) 54 0.00129
20 SGTC_1282 0886-0010 3.01 32.4 µM 3.37E-4 endomembrane recycling 70 0.00129

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.71E-19 YGL245W GUS1 het Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress
0.150 2.31E-18 YGR008C STF2 hom Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.149 3.52E-18 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.138 1.26E-15 YPR151C SUE1 hom Mitochondrial protein required for degradation of unstable forms of cytochrome c
0.134 6.11E-15 YDR277C MTH1 hom Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
0.130 5.19E-14 YGR018C_p YGR018C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W
0.120 3.50E-12 YGL131C SNT2 hom DNA binding protein with similarity to the S. pombe Snt2 protein; RING finger ubiquitin ligase (E3) involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p; null mutant sensitive to hydroxyurea (HU); computational analysis suggests that Snt2p is a transcription factor with a role in regulation of expression of genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.117 1.23E-11 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.115 2.45E-11 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.105 1.22E-9 YGL157W ARI1 hom NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily
0.104 1.76E-9 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.102 3.17E-9 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.102 3.27E-9 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.095 3.18E-8 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.095 3.38E-8 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress