YGR043C / NQM1

Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR043C / NQM1

Click on Significant Values for Screen Details ID:SGTC_432|Compound:NS 1619|FD-Score:-3.15|P-value:5.18E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.23|P-value:5.67E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:3.29|P-value:3.14E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.07|P-value:7.10E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.98|P-value:9.75E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.88|P-value:2.78E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.13|P-value:5.62E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.33|P-value:3.44E-6 ID:SGTC_2076|Compound:5212012|FD-Score:3.66|P-value:7.11E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.41|P-value:2.36E-6 ID:SGTC_2140|Compound:5586273|FD-Score:-3.26|P-value:3.45E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.49|P-value:1.43E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.32|P-value:2.82E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.87|P-value:2.93E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.35|P-value:2.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.24|P-value:3.79E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.17|P-value:7.31E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.65|P-value:7.61E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.31|P-value:2.98E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.70|P-value:5.96E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.46|P-value:1.77E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.10|P-value:6.32E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.59|P-value:9.65E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.00|P-value:9.07E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.65|P-value:7.63E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.15|P-value:5.18E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:4.23|P-value:5.67E-6 ID:SGTC_771|Compound:0250-0039|FD-Score:3.29|P-value:3.14E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.07|P-value:7.10E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-2.98|P-value:9.75E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.06|P-value:7.41E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.88|P-value:2.78E-5 ID:SGTC_1610|Compound:st001799|FD-Score:-3.13|P-value:5.62E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.33|P-value:3.44E-6 ID:SGTC_2076|Compound:5212012|FD-Score:3.66|P-value:7.11E-5 ID:SGTC_2082|Compound:5219693|FD-Score:4.41|P-value:2.36E-6 ID:SGTC_2140|Compound:5586273|FD-Score:-3.26|P-value:3.45E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.57|P-value:1.06E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.54|P-value:1.16E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.49|P-value:1.43E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.32|P-value:2.82E-4 ID:SGTC_2338|Compound:7999974|FD-Score:3.87|P-value:2.93E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.35|P-value:2.52E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.24|P-value:3.79E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.17|P-value:7.31E-6 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.19|P-value:4.67E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.65|P-value:7.61E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.31|P-value:2.98E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.70|P-value:5.96E-5 ID:SGTC_2941|Compound:9056145|FD-Score:3.29|P-value:3.11E-4 ID:SGTC_2963|Compound:9082507|FD-Score:4.46|P-value:1.77E-6 ID:SGTC_2989|Compound:9073649|FD-Score:4.10|P-value:1.03E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.10|P-value:6.32E-4 ID:SGTC_3015|Compound:9080845|FD-Score:3.59|P-value:9.65E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.00|P-value:9.07E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.65|P-value:7.63E-5

Top fitness defect scores for YGR043C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2963 9082507 4.46 9.0 µM 1.77E-6 17 4.05E-6
2 SGTC_2082 5219693 4.41 150.0 µM 2.36E-6 RNA processing & uracil transport 19 5.29E-6
3 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.33 70.1 µM 3.44E-6 16 7.51E-6
4 SGTC_760 0568-0725 4.23 82.9 µM 5.67E-6 7 1.19E-5
5 SGTC_2419 paclitaxel 4.17 166.5 µM 7.31E-6 31 1.51E-5
6 SGTC_2989 9073649 4.10 71.4 µM 1.03E-5 31 2.07E-5
7 SGTC_1572 epiandrosterone 3.88 68.9 µM 2.78E-5 28 5.23E-5
8 SGTC_2338 7999974 3.87 200.0 µM 2.93E-5 24 5.49E-5
9 SGTC_2849 9019321 3.70 13.0 µM 5.96E-5 39 1.06E-4
10 SGTC_2076 5212012 3.66 200.0 µM 7.11E-5 8 1.25E-4
11 SGTC_2537 larixol 3.65 68.9 µM 7.61E-5 30 1.33E-4
12 SGTC_3084 9116877 3.65 49.5 µM 7.63E-5 10 1.34E-4
13 SGTC_3015 9080845 3.59 49.5 µM 9.65E-5 12 1.66E-4
14 SGTC_2152 5568786 3.57 200.0 µM 1.06E-4 22 1.82E-4
15 SGTC_2155 5570423 3.54 76.0 µM 1.16E-4 ergosterol biosynthesis 15 1.97E-4
16 SGTC_2736 butenafine 3.47 14.7 µM 1.59E-4 43 2.65E-4
17 SGTC_2359 9039622 3.35 200.0 µM 2.52E-4 endomembrane recycling 37 4.07E-4
18 SGTC_2305 7443522 3.32 69.2 µM 2.82E-4 30 4.51E-4
19 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.31 100.0 µM 2.98E-4 42 4.74E-4
20 SGTC_2941 9056145 3.29 11.2 µM 3.11E-4 31 4.94E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.13E-18 YDR096W GIS1 hom Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication
0.143 9.11E-17 YLR336C SGD1 het Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia
0.127 1.69E-13 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.119 5.43E-12 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.116 1.41E-11 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.116 3.46E-11 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.109 2.88E-10 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.106 7.05E-10 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.105 9.78E-10 YPR086W SUA7 het Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.105 1.26E-9 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.101 5.25E-9 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene
0.098 1.38E-8 YPR025C CCL1 het Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
0.098 1.46E-8 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.096 2.92E-8 YEL025C_p YEL025C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.095 3.50E-8 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication