YGR051C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR051C / YGR051C

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:3.81|P-value:2.90E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.57|P-value:8.08E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.67|P-value:5.57E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.11|P-value:5.10E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-2.98|P-value:8.33E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.70|P-value:3.53E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:5.09|P-value:3.95E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:3.69|P-value:4.80E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.60|P-value:7.14E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.12|P-value:6.87E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.14|P-value:4.51E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.55|P-value:9.00E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.29|P-value:2.52E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.82|P-value:2.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.96|P-value:9.01E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.13|P-value:4.76E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.41|P-value:1.62E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.22|P-value:3.43E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.17|P-value:4.12E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.67|P-value:5.50E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.32|P-value:2.30E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.12|P-value:4.97E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.27|P-value:2.87E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.24|P-value:3.13E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:2.96|P-value:8.95E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.07|P-value:6.04E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.90|P-value:1.88E-5 ID:SGTC_3020|Compound:9089140|FD-Score:2.95|P-value:9.24E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.84|P-value:2.54E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.28|P-value:1.31E-8 ID:SGTC_3307|Compound:9126885|FD-Score:-5.56|P-value:2.31E-9 ID:SGTC_3309|Compound:9129340|FD-Score:-3.57|P-value:8.51E-5 ID:SGTC_7|Compound:0192-1582|FD-Score:3.81|P-value:2.90E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.57|P-value:8.08E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.67|P-value:5.57E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:2.94|P-value:9.47E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.11|P-value:5.10E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:-2.98|P-value:8.33E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:4.70|P-value:3.53E-7 ID:SGTC_977|Compound:1348-1378|FD-Score:5.09|P-value:3.95E-8 ID:SGTC_978|Compound:1416-0512|FD-Score:3.69|P-value:4.80E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.60|P-value:7.14E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:4.12|P-value:6.87E-6 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.14|P-value:4.51E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.55|P-value:9.00E-5 ID:SGTC_1620|Compound:st003704|FD-Score:3.29|P-value:2.52E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.82|P-value:2.84E-5 ID:SGTC_1697|Compound:st025554|FD-Score:2.96|P-value:9.01E-4 ID:SGTC_1891|Compound:st059073|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.13|P-value:4.76E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.29|P-value:2.59E-4 ID:SGTC_1962|Compound:st076595|FD-Score:4.41|P-value:1.62E-6 ID:SGTC_2054|Compound:5233173|FD-Score:3.22|P-value:3.43E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.17|P-value:4.12E-4 ID:SGTC_2267|Compound:7931562|FD-Score:-3.67|P-value:5.50E-5 ID:SGTC_2284|Compound:7945075|FD-Score:-3.02|P-value:7.17E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.32|P-value:2.30E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.12|P-value:4.97E-4 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.54|P-value:9.31E-5 ID:SGTC_2591|Compound:skatole|FD-Score:-3.27|P-value:2.87E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.24|P-value:3.13E-4 ID:SGTC_2760|Compound:etidronate|FD-Score:2.96|P-value:8.95E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-3.07|P-value:6.04E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.90|P-value:1.88E-5 ID:SGTC_3020|Compound:9089140|FD-Score:2.95|P-value:9.24E-4 ID:SGTC_3232|Compound:9132874|FD-Score:3.84|P-value:2.54E-5 ID:SGTC_3299|Compound:9121982|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-5.28|P-value:1.31E-8 ID:SGTC_3307|Compound:9126885|FD-Score:-5.56|P-value:2.31E-9 ID:SGTC_3309|Compound:9129340|FD-Score:-3.57|P-value:8.51E-5

Top fitness defect scores for YGR051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_977 1348-1378 5.09 135.0 µM 3.95E-8 9 1.82E-7
2 SGTC_976 1348-1067 4.70 47.6 µM 3.53E-7 60S ribosome export 14 1.31E-6
3 SGTC_1962 st076595 4.41 64.5 µM 1.62E-6 redox potentiating 19 5.17E-6
4 SGTC_1206 3978-0017 4.12 132.0 µM 6.87E-6 ERG2 30 1.91E-5
5 SGTC_2967 9089538 3.90 49.9 µM 1.88E-5 35 4.72E-5
6 SGTC_3232 9132874 3.84 49.5 µM 2.54E-5 RPP1 & pyrimidine depletion 17 6.20E-5
7 SGTC_7 0192-1582 3.81 4.2 µM 2.90E-5 62 6.99E-5
8 SGTC_978 1416-0512 3.69 87.4 µM 4.80E-5 redox potentiating 34 1.10E-4
9 SGTC_979 1426-2828 3.60 121.0 µM 7.14E-5 27 1.58E-4
10 SGTC_46 0329-0187a 3.57 2.2 µM 8.08E-5 92 1.76E-4
11 SGTC_1396 3511-0007 3.55 98.6 µM 9.00E-5 mitochondrial processes 22 1.94E-4
12 SGTC_2587 piperic acid 3.54 92.2 µM 9.31E-5 35 2.01E-4
13 SGTC_853 0419-0306 3.34 21.0 µM 2.10E-4 35 4.17E-4
14 SGTC_2452 5863136 3.32 48.4 µM 2.30E-4 46 4.54E-4
15 SGTC_1620 st003704 3.29 16.5 µM 2.52E-4 36 4.94E-4
16 SGTC_1953 st076800 3.29 12.1 µM 2.59E-4 81 5.06E-4
17 SGTC_1050 3232-1156 3.26 69.3 µM 2.88E-4 RSC complex & mRNA processing 48 5.55E-4
18 SGTC_2054 5233173 3.22 129.0 µM 3.43E-4 mitochondrial response to ROS 95 6.50E-4
19 SGTC_2101 5377231 3.17 179.2 µM 4.12E-4 23 7.68E-4
20 SGTC_1259 0671-0132 3.14 43.0 µM 4.51E-4 62 8.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 6.46E-17 YOL075C_p YOL075C_p hom Putative ABC transporter
0.107 6.06E-10 YDR218C SPR28 hom Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
0.095 3.16E-8 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.091 1.33E-7 YMR272C SCS7 hom Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
0.090 2.04E-7 YOL098C_p YOL098C_p hom Putative metalloprotease
0.089 2.70E-7 YJR047C ANB1 hom Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
0.089 2.79E-7 YJR109C CPA2 hom Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
0.088 3.54E-7 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.088 3.76E-7 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.087 4.94E-7 YLR093C NYV1 hom v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
0.085 7.77E-7 YFR054C_d YFR054C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.25E-6 YGR129W SYF2 hom Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest
0.079 4.07E-6 YDL040C NAT1 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.079 4.40E-6 YDL156W CMR1 hom DNA-binding protein with preference for UV-damaged DNA; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the promoter region; co-localizes with Hos2p in nuclear foci in response to DNA damage by MMS
0.078 6.51E-6 YJL121C RPE1 hom D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress