YGR059W / SPR3

Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR059W / SPR3

Click on Significant Values for Screen Details ID:SGTC_313|Compound:3474-0040|FD-Score:-3.84|P-value:4.30E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.72|P-value:7.10E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.90|P-value:3.60E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:3.15|P-value:6.69E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.53|P-value:1.60E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.09|P-value:8.13E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.73|P-value:7.34E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.43|P-value:2.23E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.59|P-value:1.20E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.37|P-value:2.94E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.09|P-value:7.92E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.77|P-value:5.69E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.06|P-value:9.12E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.28|P-value:6.53E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.43|P-value:2.37E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.35|P-value:3.22E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:4.04E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.12|P-value:7.00E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.48|P-value:2.31E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.06|P-value:8.57E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:3.57E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.17|P-value:5.78E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.41|P-value:2.54E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.02|P-value:2.14E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.07|P-value:8.73E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.24|P-value:4.80E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.05|P-value:9.43E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.41|P-value:2.57E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.17|P-value:1.09E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.56|P-value:1.36E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.04|P-value:9.76E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.84|P-value:4.30E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.72|P-value:7.10E-5 ID:SGTC_781|Compound:4335-2806|FD-Score:3.33|P-value:3.49E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:3.90|P-value:3.60E-5 ID:SGTC_812|Compound:4251-0442|FD-Score:3.15|P-value:6.69E-4 ID:SGTC_973|Compound:1325-0077|FD-Score:3.52|P-value:1.71E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.53|P-value:1.60E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:-3.58|P-value:1.23E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.29|P-value:4.05E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.09|P-value:8.13E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.73|P-value:7.34E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:-3.43|P-value:2.23E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.31|P-value:3.80E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:-3.59|P-value:1.20E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:3.62|P-value:1.12E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.37|P-value:2.94E-4 ID:SGTC_1652|Compound:st011932|FD-Score:-3.09|P-value:7.92E-4 ID:SGTC_1670|Compound:st016595|FD-Score:3.39|P-value:2.78E-4 ID:SGTC_1710|Compound:st031758|FD-Score:-3.77|P-value:5.69E-5 ID:SGTC_1716|Compound:st033144|FD-Score:3.06|P-value:9.12E-4 ID:SGTC_1731|Compound:st035964|FD-Score:4.28|P-value:6.53E-6 ID:SGTC_1917|Compound:st066507|FD-Score:3.43|P-value:2.37E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.35|P-value:3.22E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.29|P-value:4.04E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.54|P-value:1.55E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.12|P-value:7.00E-4 ID:SGTC_2288|Compound:7946289|FD-Score:-3.26|P-value:4.26E-4 ID:SGTC_2290|Compound:7904846|FD-Score:3.70|P-value:8.11E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.48|P-value:2.31E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.06|P-value:8.57E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:3.57E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:-3.17|P-value:5.78E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.41|P-value:2.54E-4 ID:SGTC_2981|Compound:9013952|FD-Score:4.02|P-value:2.14E-5 ID:SGTC_3047|Compound:9092122|FD-Score:3.07|P-value:8.73E-4 ID:SGTC_3068|Compound:9116768|FD-Score:3.24|P-value:4.80E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.05|P-value:9.43E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.67|P-value:9.22E-5 ID:SGTC_3174|Compound:9107204|FD-Score:3.35|P-value:3.19E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.41|P-value:2.57E-4 ID:SGTC_3216|Compound:9129716|FD-Score:4.17|P-value:1.09E-5 ID:SGTC_3217|Compound:9129673|FD-Score:-3.56|P-value:1.36E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.04|P-value:9.76E-4

Top fitness defect scores for YGR059W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1731 st035964 4.28 63.0 µM 6.53E-6 21 9.44E-6
2 SGTC_3216 9129716 4.17 49.5 µM 1.09E-5 RPP1 & pyrimidine depletion 19 1.55E-5
3 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 4.11 200.0 µM 1.40E-5 10 1.96E-5
4 SGTC_2981 9013952 4.02 39.0 µM 2.14E-5 43 2.96E-5
5 SGTC_790 1575-0012 3.90 79.1 µM 3.60E-5 TSC3-RPN4 29 4.89E-5
6 SGTC_1368 1852-0141 3.73 284.0 µM 7.34E-5 ERG2 42 9.71E-5
7 SGTC_2290 7904846 3.70 200.0 µM 8.11E-5 29 1.07E-4
8 SGTC_3144 9087057 3.67 49.5 µM 9.22E-5 19 1.21E-4
9 SGTC_1570 verbenone 3.62 133.0 µM 1.12E-4 24 1.46E-4
10 SGTC_2184 6075246 3.54 200.0 µM 1.55E-4 39 1.99E-4
11 SGTC_976 1348-1067 3.53 47.6 µM 1.60E-4 60S ribosome export 47 2.06E-4
12 SGTC_973 1325-0077 3.52 65.9 µM 1.71E-4 19 2.19E-4
13 SGTC_1917 st066507 3.43 28.5 µM 2.37E-4 Golgi 64 3.01E-4
14 SGTC_2741 miltefosine 3.41 3.0 µM 2.54E-4 50 3.22E-4
15 SGTC_3182 9108849 3.41 49.5 µM 2.57E-4 RPP1 & pyrimidine depletion 25 3.25E-4
16 SGTC_1670 st016595 3.39 4.0 µM 2.78E-4 24 3.50E-4
17 SGTC_1630 st005209 3.37 31.3 µM 2.94E-4 48 3.70E-4
18 SGTC_3174 9107204 3.35 49.5 µM 3.19E-4 ERG2 59 4.00E-4
19 SGTC_2042 p-Dimethylaminoacetophenone 3.35 200.0 µM 3.22E-4 44 4.03E-4
20 SGTC_781 4335-2806 3.33 94.4 µM 3.49E-4 39 4.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.69E-11 YNL193W_p YNL193W_p hom Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
0.104 1.29E-9 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.090 1.63E-7 YGR226C_d YGR226C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
0.079 4.70E-6 YLR089C ALT1 hom Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; expression is induced in the presence of alanine; repression is mediated by Nrg1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; paralogous gene ALT2 is catalytically inactive
0.076 9.96E-6 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.076 1.03E-5 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.075 1.46E-5 YOL087C DUF1 hom Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
0.074 1.61E-5 YOR041C_d YOR041C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance
0.070 5.35E-5 YNL155W YNL155W hom Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress
0.069 6.47E-5 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.068 8.03E-5 YJL079C PRY1 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication
0.068 8.32E-5 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.068 8.54E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.068 8.70E-5 YPR128C ANT1 hom Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
0.067 9.65E-5 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR