YGR066C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR066C / YGR066C

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:3.40|P-value:5.50E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.77|P-value:1.10E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.28|P-value:8.34E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.15|P-value:3.24E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.25|P-value:9.03E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.29|P-value:8.00E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-4.73|P-value:1.86E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.68|P-value:3.36E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.33|P-value:1.56E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.18|P-value:8.83E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.37|P-value:4.63E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.65|P-value:3.89E-6 ID:SGTC_1892|Compound:st058411|FD-Score:4.27|P-value:2.01E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:6.03|P-value:3.09E-9 ID:SGTC_2404|Compound:5161160|FD-Score:4.11|P-value:3.83E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.46|P-value:4.57E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.81|P-value:9.37E-5 ID:SGTC_2691|Compound:st077356|FD-Score:4.15|P-value:3.34E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.26|P-value:8.80E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.78|P-value:1.40E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:3.40|P-value:5.50E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.77|P-value:1.10E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.28|P-value:8.34E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:4.15|P-value:3.24E-5 ID:SGTC_962|Compound:1254-0300|FD-Score:3.25|P-value:9.03E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.29|P-value:8.00E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:-4.73|P-value:1.86E-6 ID:SGTC_1296|Compound:1068-0102|FD-Score:4.68|P-value:3.36E-6 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.33|P-value:1.56E-5 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.18|P-value:8.83E-4 ID:SGTC_1771|Compound:st048882|FD-Score:-3.37|P-value:4.63E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.86|P-value:1.04E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.65|P-value:3.89E-6 ID:SGTC_1892|Compound:st058411|FD-Score:4.27|P-value:2.01E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.68|P-value:2.07E-4 ID:SGTC_2394|Compound:5221648|FD-Score:6.03|P-value:3.09E-9 ID:SGTC_2404|Compound:5161160|FD-Score:4.11|P-value:3.83E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:3.46|P-value:4.57E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.81|P-value:9.37E-5 ID:SGTC_2691|Compound:st077356|FD-Score:4.15|P-value:3.34E-5 ID:SGTC_2937|Compound:9044753|FD-Score:3.26|P-value:8.80E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.78|P-value:1.40E-4

Top fitness defect scores for YGR066C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2394 5221648 6.03 200.0 µM 3.09E-9 3 8.35E-10
2 SGTC_1296 1068-0102 4.68 11.9 µM 3.36E-6 5 1.45E-6
3 SGTC_1879 gemcitabine 4.65 100.0 µM 3.89E-6 4 1.69E-6
4 SGTC_1342 1486-1464 4.33 234.0 µM 1.56E-5 9 7.43E-6
5 SGTC_1892 st058411 4.27 7.4 µM 2.01E-5 14 9.77E-6
6 SGTC_956 1185-0240 4.15 191.0 µM 3.24E-5 17 1.63E-5
7 SGTC_2691 st077356 4.15 60.2 µM 3.34E-5 21 1.68E-5
8 SGTC_2404 5161160 4.11 200.0 µM 3.83E-5 15 1.95E-5
9 SGTC_1795 st049545 3.86 62.3 µM 1.04E-4 TSC3-RPN4 12 5.64E-5
10 SGTC_3013 9080133 3.78 71.4 µM 1.40E-4 24 7.74E-5
11 SGTC_2264 7948757 3.68 110.8 µM 2.07E-4 24 1.18E-4
12 SGTC_2170 morpholine 3.48 200.0 µM 4.15E-4 22 2.48E-4
13 SGTC_2606 farnesol 3.46 9.8 µM 4.57E-4 37 2.74E-4
14 SGTC_98 0074-0023 3.40 107.7 µM 5.50E-4 Golgi 62 3.35E-4
15 SGTC_1127 asiatic acid 3.29 681.4 nM 8.00E-4 45 5.00E-4
16 SGTC_429 1112-0049 3.28 25.5 µM 8.34E-4 DNA damage response 62 5.22E-4
17 SGTC_2937 9044753 3.26 11.3 µM 8.80E-4 60S ribosome export 61 5.53E-4
18 SGTC_962 1254-0300 3.25 21.5 µM 9.03E-4 50 5.69E-4
19 SGTC_3300 9124615 3.18 50.5 µM 0.00114 49 7.31E-4
20 SGTC_1902 st060212 3.10 70.5 µM 0.00148 50 9.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 4.76E-19 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.145 3.04E-17 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.126 2.59E-13 YPL092W SSU1 hom Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
0.118 6.83E-12 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.117 8.96E-12 YBR290W BSD2 hom Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification
0.106 6.30E-10 YLR387C REH1 hom Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
0.104 1.44E-9 YDR147W EKI1 hom Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication
0.096 3.10E-8 YFR028C CDC14 het Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required for meiosis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis
0.093 6.74E-8 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.093 7.56E-8 YBR076W ECM8 hom Non-essential protein of unknown function
0.092 1.00E-7 YPR145W ASN1 hom Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication
0.084 1.19E-6 YCR012W PGK1 het 3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
0.081 2.64E-6 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.079 4.10E-6 YGR040W KSS1 hom Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
0.079 5.10E-6 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity