YGR067C_p

Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR067C / YGR067C

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.22|P-value:2.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.01|P-value:5.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:7.10|P-value:1.08E-14 ID:SGTC_300|Compound:r073-0011|FD-Score:3.13|P-value:3.70E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.27|P-value:2.29E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.31|P-value:1.93E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.21|P-value:2.85E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.07|P-value:4.86E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.57|P-value:6.15E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.59|P-value:5.63E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.31|P-value:1.77E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.16|P-value:3.55E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.46|P-value:8.07E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:-4.02|P-value:7.98E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.14|P-value:4.53E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:2.92|P-value:8.34E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.32|P-value:1.76E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.20|P-value:2.99E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.08|P-value:5.62E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-8.90|P-value:6.16E-22 ID:SGTC_1732|Compound:st034308|FD-Score:-10.40|P-value:1.67E-29 ID:SGTC_1733|Compound:st037357|FD-Score:-3.47|P-value:9.82E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-8.51|P-value:3.11E-20 ID:SGTC_1835|Compound:st008666|FD-Score:-3.12|P-value:4.02E-4 ID:SGTC_2031|Compound:5180455|FD-Score:2.97|P-value:7.00E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.23|P-value:2.60E-6 ID:SGTC_2270|Compound:7924575|FD-Score:3.67|P-value:3.89E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.01|P-value:5.96E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.00|P-value:6.09E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:4.23|P-value:2.66E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.68|P-value:3.89E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.49|P-value:8.55E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.55|P-value:6.84E-5 ID:SGTC_2978|Compound:9011784|FD-Score:2.91|P-value:8.71E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.32|P-value:1.69E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.17|P-value:3.35E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.06|P-value:4.93E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.25|P-value:2.31E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.03|P-value:5.80E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.06|P-value:5.01E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.22|P-value:2.73E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.01|P-value:5.92E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:7.10|P-value:1.08E-14 ID:SGTC_300|Compound:r073-0011|FD-Score:3.13|P-value:3.70E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:-3.27|P-value:2.29E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-3.31|P-value:1.93E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:-3.21|P-value:2.85E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.07|P-value:4.86E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:3.57|P-value:6.15E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:3.59|P-value:5.63E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:4.31|P-value:1.77E-6 ID:SGTC_1041|Compound:0206-0046|FD-Score:-3.16|P-value:3.55E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.46|P-value:8.07E-7 ID:SGTC_1096|Compound:rimcazole|FD-Score:-4.02|P-value:7.98E-6 ID:SGTC_1128|Compound:3448-9350|FD-Score:-4.14|P-value:4.53E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:2.92|P-value:8.34E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-4.32|P-value:1.76E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-3.20|P-value:2.99E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.08|P-value:5.62E-6 ID:SGTC_1730|Compound:st033808|FD-Score:-8.90|P-value:6.16E-22 ID:SGTC_1732|Compound:st034308|FD-Score:-10.40|P-value:1.67E-29 ID:SGTC_1733|Compound:st037357|FD-Score:-3.47|P-value:9.82E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-8.51|P-value:3.11E-20 ID:SGTC_1835|Compound:st008666|FD-Score:-3.12|P-value:4.02E-4 ID:SGTC_2031|Compound:5180455|FD-Score:2.97|P-value:7.00E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.22|P-value:2.63E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.23|P-value:2.60E-6 ID:SGTC_2270|Compound:7924575|FD-Score:3.67|P-value:3.89E-5 ID:SGTC_2281|Compound:7943571|FD-Score:3.01|P-value:5.96E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.00|P-value:6.09E-4 ID:SGTC_2505|Compound:galangin|FD-Score:-3.16|P-value:3.52E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:4.23|P-value:2.66E-6 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-3.06|P-value:5.21E-4 ID:SGTC_2707|Compound:st078556|FD-Score:-3.68|P-value:3.89E-5 ID:SGTC_2800|Compound:7887935|FD-Score:3.49|P-value:8.55E-5 ID:SGTC_2933|Compound:9026794|FD-Score:-3.55|P-value:6.84E-5 ID:SGTC_2978|Compound:9011784|FD-Score:2.91|P-value:8.71E-4 ID:SGTC_3144|Compound:9087057|FD-Score:4.32|P-value:1.69E-6 ID:SGTC_3331|Compound:9141060|FD-Score:-3.17|P-value:3.35E-4 ID:SGTC_3334|Compound:9142812|FD-Score:3.06|P-value:4.93E-4 ID:SGTC_3349|Compound:9149703|FD-Score:3.25|P-value:2.31E-4 ID:SGTC_3352|Compound:9151559|FD-Score:-3.03|P-value:5.80E-4

Top fitness defect scores for YGR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_219 mitoxanthrone 7.10 164.4 µM 1.08E-14 DNA intercalators 16 6.02E-13
2 SGTC_1065 prochlorperazine maleate 4.46 2.5 µM 8.07E-7 8 4.13E-6
3 SGTC_3144 9087057 4.32 49.5 µM 1.69E-6 10 7.84E-6
4 SGTC_1028 k015-0029 4.31 4.8 µM 1.77E-6 15 8.20E-6
5 SGTC_2111 5486399 4.23 200.0 µM 2.60E-6 37 1.15E-5
6 SGTC_2644 guaiazulene 4.23 100.0 µM 2.66E-6 2 1.17E-5
7 SGTC_1728 st035614 4.08 33.8 µM 5.62E-6 41 2.24E-5
8 SGTC_2270 7924575 3.67 90.9 µM 3.89E-5 RPP1 & pyrimidine depletion 19 1.21E-4
9 SGTC_996 3970-0799 3.59 1.8 µM 5.63E-5 106 1.66E-4
10 SGTC_616 4092-0450 3.57 108.0 µM 6.15E-5 21 1.80E-4
11 SGTC_2800 7887935 3.49 81.8 µM 8.55E-5 RPP1 & pyrimidine depletion 51 2.40E-4
12 SGTC_1373 2887-0003 3.39 58.5 µM 1.31E-4 Golgi 38 3.47E-4
13 SGTC_3349 9149703 3.25 23.0 µM 2.31E-4 33 5.69E-4
14 SGTC_2099 5377090 3.22 177.4 µM 2.63E-4 55 6.38E-4
15 SGTC_300 r073-0011 3.13 5.0 µM 3.70E-4 51 8.60E-4
16 SGTC_3334 9142812 3.06 21.9 µM 4.93E-4 62 0.00111
17 SGTC_36 0335-0881 3.06 14.2 µM 5.01E-4 ubiquinone biosynthesis & proteasome 171 0.00112
18 SGTC_43 0570-0105 3.01 72.5 µM 5.92E-4 ERG2 180 0.00130
19 SGTC_2281 7943571 3.01 200.0 µM 5.96E-4 37 0.00130
20 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.00 3.7 µM 6.09E-4 203 0.00133

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 6.40E-36 YDR171W HSP42 hom Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.196 2.68E-30 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.178 3.42E-25 YGR249W MGA1 hom Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
0.149 4.06E-18 YDL018C ERP3 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.144 5.85E-17 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.137 1.95E-15 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.137 1.57E-15 YGR075C PRP38 het Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
0.135 4.47E-15 YDR309C GIC2 hom Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.122 1.14E-12 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.121 1.82E-12 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.120 2.91E-12 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.120 2.99E-12 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.120 3.36E-12 YGR048W UFD1 het Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.117 1.07E-11 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.115 2.09E-11 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress