YGR071C / ENV11

Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR071C / ENV11

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:2.88|P-value:7.88E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.27|P-value:1.66E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.15|P-value:2.76E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.67|P-value:2.78E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.12|P-value:3.04E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.99|P-value:5.20E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.45|P-value:6.60E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:6.19|P-value:4.61E-12 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.00|P-value:4.87E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-2.89|P-value:6.58E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:2.91|P-value:7.15E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.00|P-value:4.39E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.36|P-value:8.31E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.53|P-value:4.59E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.55|P-value:2.69E-13 ID:SGTC_834|Compound:0312-0008|FD-Score:3.03|P-value:4.45E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.11|P-value:3.26E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-2.85|P-value:7.76E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.12|P-value:3.03E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.63|P-value:3.39E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.41|P-value:7.62E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.75|P-value:1.92E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.08|P-value:3.12E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.75|P-value:8.60E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:-2.86|P-value:7.35E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.99|P-value:4.97E-6 ID:SGTC_1836|Compound:st055642|FD-Score:2.85|P-value:8.77E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.85|P-value:8.71E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.26|P-value:1.71E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.77|P-value:1.71E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.08|P-value:3.20E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.76|P-value:1.78E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.02|P-value:4.19E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-2.98|P-value:4.77E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-2.80|P-value:9.40E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:2.19E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.01|P-value:4.77E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.19|P-value:2.32E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-2.88|P-value:6.84E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.30|P-value:1.46E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-4.18|P-value:1.77E-6 ID:SGTC_2924|Compound:9010168|FD-Score:7.07|P-value:3.60E-15 ID:SGTC_2933|Compound:9026794|FD-Score:2.83|P-value:9.34E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.13|P-value:2.55E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-2.84|P-value:7.94E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.31|P-value:1.10E-6 ID:SGTC_3050|Compound:9093513|FD-Score:2.91|P-value:6.93E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.67|P-value:2.40E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.01|P-value:4.82E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:2.88|P-value:7.88E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.18|P-value:2.42E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.27|P-value:1.66E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.15|P-value:2.76E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.91|P-value:6.94E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.67|P-value:2.78E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:3.12|P-value:3.04E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:2.99|P-value:5.20E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.45|P-value:6.60E-5 ID:SGTC_366|Compound:0181-0206|FD-Score:6.19|P-value:4.61E-12 ID:SGTC_452|Compound:diindolylmethane|FD-Score:3.00|P-value:4.87E-4 ID:SGTC_526|Compound:4469-0568|FD-Score:-2.89|P-value:6.58E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:2.91|P-value:7.15E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:-3.00|P-value:4.39E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.36|P-value:8.31E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-3.53|P-value:4.59E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.55|P-value:2.69E-13 ID:SGTC_834|Compound:0312-0008|FD-Score:3.03|P-value:4.45E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.11|P-value:3.26E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:-2.85|P-value:7.76E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.12|P-value:3.03E-4 ID:SGTC_918|Compound:glabranin|FD-Score:3.63|P-value:3.39E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:-3.41|P-value:7.62E-5 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.18|P-value:2.45E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.75|P-value:1.92E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:-4.08|P-value:3.12E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.75|P-value:8.60E-8 ID:SGTC_1448|Compound:4255-0083|FD-Score:-2.86|P-value:7.35E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.99|P-value:4.97E-6 ID:SGTC_1836|Compound:st055642|FD-Score:2.85|P-value:8.77E-4 ID:SGTC_1889|Compound:st059080|FD-Score:2.85|P-value:8.71E-4 ID:SGTC_2101|Compound:5377231|FD-Score:3.26|P-value:1.71E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.77|P-value:1.71E-5 ID:SGTC_2305|Compound:7443522|FD-Score:-3.08|P-value:3.20E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.76|P-value:1.78E-5 ID:SGTC_2359|Compound:9039622|FD-Score:-4.02|P-value:4.19E-6 ID:SGTC_2368|Compound:9071271|FD-Score:-2.98|P-value:4.77E-4 ID:SGTC_2397|Compound:5161689|FD-Score:-2.80|P-value:9.40E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.17|P-value:2.19E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:3.01|P-value:4.77E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.19|P-value:2.32E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-2.88|P-value:6.84E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.30|P-value:1.46E-4 ID:SGTC_2827|Compound:7993847|FD-Score:-4.18|P-value:1.77E-6 ID:SGTC_2924|Compound:9010168|FD-Score:7.07|P-value:3.60E-15 ID:SGTC_2933|Compound:9026794|FD-Score:2.83|P-value:9.34E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.13|P-value:2.55E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-2.84|P-value:7.94E-4 ID:SGTC_2950|Compound:9072895|FD-Score:4.31|P-value:1.10E-6 ID:SGTC_3050|Compound:9093513|FD-Score:2.91|P-value:6.93E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.67|P-value:2.40E-5 ID:SGTC_3272|Compound:9137413|FD-Score:3.01|P-value:4.82E-4

Top fitness defect scores for YGR071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2924 9010168 7.07 62.8 µM 3.60E-15 cell wall signaling 4 7.98E-13
2 SGTC_825 1988-2224 6.55 89.6 µM 2.69E-13 cell wall signaling 10 2.82E-11
3 SGTC_366 0181-0206 6.19 4.3 µM 4.61E-12 Golgi 8 2.94E-10
4 SGTC_1226 3909-7979 4.75 35.4 µM 8.60E-8 27 1.01E-6
5 SGTC_568 1193-0097 4.36 7.5 µM 8.31E-7 ERAD & cell cycle 122 6.60E-6
6 SGTC_2950 9072895 4.31 21.5 µM 1.10E-6 28 8.31E-6
7 SGTC_2249 haloperidol 3.77 116.4 µM 1.71E-5 ergosterol depletion effects on membrane 128 8.14E-5
8 SGTC_2308 7584454 3.76 197.6 µM 1.78E-5 24 8.40E-5
9 SGTC_1016 4226-1401 3.75 38.0 µM 1.92E-5 RNA pol III & RNase P/MRP 22 8.98E-5
10 SGTC_127 0180-0333 3.67 59.1 µM 2.78E-5 mitochondrial response to ROS 57 1.22E-4
11 SGTC_918 glabranin 3.63 770.7 nM 3.39E-5 43 1.44E-4
12 SGTC_2816 7982706 3.30 58.4 µM 1.46E-4 azole & statin 86 4.87E-4
13 SGTC_64 000l-0018 3.27 272.1 µM 1.66E-4 ubiquinone biosynthesis & proteasome 194 5.42E-4
14 SGTC_2101 5377231 3.26 179.2 µM 1.71E-4 19 5.54E-4
15 SGTC_2592 piperlongumine 3.19 83.3 µM 2.32E-4 TSC3-RPN4 70 7.15E-4
16 SGTC_46 0329-0187a 3.18 2.2 µM 2.42E-4 115 7.43E-4
17 SGTC_1010 4112-3296 3.18 15.2 µM 2.45E-4 48 7.48E-4
18 SGTC_87 0100-0052 3.15 35.5 µM 2.76E-4 194 8.28E-4
19 SGTC_878 0828-0289 3.12 13.7 µM 3.03E-4 97 8.94E-4
20 SGTC_178 4092-0806 3.12 87.5 µM 3.04E-4 ergosterol depletion effects on membrane 147 8.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.15E-16 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.139 5.87E-16 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.138 8.65E-16 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.137 1.57E-15 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.123 9.12E-13 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.117 1.02E-11 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.116 1.36E-11 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.115 2.44E-11 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.114 4.12E-11 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.113 4.79E-11 YNL077W APJ1 hom Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress
0.112 7.78E-11 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.111 1.31E-10 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.110 1.68E-10 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.109 2.62E-10 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.107 4.68E-10 YDL040C NAT1 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing