YGR085C / RPL11B

Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR085C / RPL11B

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.50|P-value:8.36E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.40|P-value:1.26E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.68|P-value:2.99E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.38|P-value:5.73E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.51|P-value:3.68E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.47|P-value:6.18E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.24|P-value:2.43E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.51|P-value:7.07E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.61|P-value:5.17E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:6.28E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.32|P-value:2.72E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:-3.37|P-value:6.04E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.50|P-value:5.52E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.33|P-value:9.64E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.03|P-value:8.45E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.67|P-value:3.10E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.50|P-value:1.29E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.67|P-value:2.17E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.32|P-value:7.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.80|P-value:1.34E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.40|P-value:7.76E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.59|P-value:8.81E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.07|P-value:7.23E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-3.54|P-value:3.40E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.03|P-value:7.56E-9 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.55|P-value:6.71E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:-4.13|P-value:3.75E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-7.91|P-value:2.38E-14 ID:SGTC_2521|Compound:angolensin|FD-Score:3.52|P-value:5.23E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.68|P-value:5.85E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.08|P-value:6.89E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.46|P-value:6.26E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.97|P-value:1.01E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.91|P-value:1.35E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.14|P-value:5.58E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.27|P-value:8.31E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-3.44|P-value:4.81E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.50|P-value:8.36E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.40|P-value:1.26E-7 ID:SGTC_170|Compound:4197-0004|FD-Score:3.68|P-value:2.99E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.38|P-value:5.73E-4 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.51|P-value:3.68E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:3.47|P-value:6.18E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.24|P-value:2.43E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-5.51|P-value:7.07E-8 ID:SGTC_513|Compound:4245-1575|FD-Score:-4.61|P-value:5.17E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.00|P-value:6.28E-5 ID:SGTC_538|Compound:2922-0838|FD-Score:3.90|P-value:1.36E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.32|P-value:2.72E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:-3.37|P-value:6.04E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.50|P-value:5.52E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.33|P-value:9.64E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:4.03|P-value:8.45E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:3.67|P-value:3.10E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:5.50|P-value:1.29E-7 ID:SGTC_1450|Compound:4112-4260|FD-Score:-3.67|P-value:2.17E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.32|P-value:7.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.75|P-value:2.34E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.80|P-value:1.34E-4 ID:SGTC_1916|Compound:st067606|FD-Score:3.40|P-value:7.76E-4 ID:SGTC_2179|Compound:6298986|FD-Score:4.59|P-value:8.81E-6 ID:SGTC_2417|Compound:cerulenin|FD-Score:4.07|P-value:7.23E-5 ID:SGTC_2426|Compound:5582046|FD-Score:-3.54|P-value:3.40E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:6.03|P-value:7.56E-9 ID:SGTC_2515|Compound:chrysin|FD-Score:-4.55|P-value:6.71E-6 ID:SGTC_2518|Compound:prenyletin|FD-Score:-4.13|P-value:3.75E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-7.91|P-value:2.38E-14 ID:SGTC_2521|Compound:angolensin|FD-Score:3.52|P-value:5.23E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.68|P-value:5.85E-6 ID:SGTC_2831|Compound:7999036|FD-Score:4.08|P-value:6.89E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.46|P-value:6.26E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.97|P-value:1.01E-6 ID:SGTC_3152|Compound:9099253|FD-Score:-4.91|P-value:1.35E-6 ID:SGTC_3178|Compound:9107506|FD-Score:4.14|P-value:5.58E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-3.27|P-value:8.31E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-3.44|P-value:4.81E-4

Top fitness defect scores for YGR085C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2514 salinomycin 6.03 42.7 µM 7.56E-9 14 7.96E-10
2 SGTC_1446 4239-0190 5.50 62.0 µM 1.29E-7 9 1.93E-8
3 SGTC_2612 dictamnine 4.68 15.5 µM 5.85E-6 RNA pol III & RNase P/MRP 27 1.40E-6
4 SGTC_2179 6298986 4.59 200.0 µM 8.81E-6 heme requiring 10 2.22E-6
5 SGTC_755 1995-0008 4.32 37.3 µM 2.72E-5 16 7.86E-6
6 SGTC_3178 9107506 4.14 49.5 µM 5.58E-5 11 1.76E-5
7 SGTC_2831 7999036 4.08 19.5 µM 6.89E-5 42 2.24E-5
8 SGTC_2417 cerulenin 4.07 830.0 nM 7.23E-5 29 2.36E-5
9 SGTC_1120 ficusin 4.03 1.8 µM 8.45E-5 25 2.81E-5
10 SGTC_538 2922-0838 3.90 53.3 µM 1.36E-4 Golgi 30 4.79E-5
11 SGTC_1456 k015-0012 3.75 13.0 µM 2.34E-4 38 8.83E-5
12 SGTC_170 4197-0004 3.68 226.0 µM 2.99E-4 22 1.16E-4
13 SGTC_1326 1431-2094 3.67 10.8 µM 3.10E-4 tubulin folding & SWR complex 44 1.21E-4
14 SGTC_2521 angolensin 3.52 13.4 µM 5.23E-4 18 2.18E-4
15 SGTC_892 0929-0076 3.50 29.0 µM 5.52E-4 TRP & mitochondrial translation 63 2.32E-4
16 SGTC_258 haloperidol 3.47 50.8 µM 6.18E-4 fatty acid desaturase (OLE1) 44 2.63E-4
17 SGTC_2839 9003951 3.46 26.0 µM 6.26E-4 22 2.67E-4
18 SGTC_1916 st067606 3.40 49.2 µM 7.76E-4 66 3.40E-4
19 SGTC_1022 4477-0945 3.33 21.3 µM 9.64E-4 49 4.34E-4
20 SGTC_1481 3346-2004 3.26 36.0 µM 0.00119 24 5.48E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 6.78E-19 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.129 6.06E-14 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.127 1.75E-13 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.121 1.74E-12 YAL047C SPC72 hom Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization
0.111 1.30E-10 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.110 1.77E-10 YBR084C-A RPL19A hom Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication
0.109 2.23E-10 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate
0.101 5.20E-9 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.100 6.88E-9 YLR448W RPL6B hom Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication
0.097 1.81E-8 YDL008W APC11 het Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
0.094 4.83E-8 YMR182W-A_p YMR182W-A_p hom Putative protein of unknown function
0.093 6.30E-8 YGL188C-A_p YGL188C-A_p hom Putative protein of unknown function
0.093 7.36E-8 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.093 7.60E-8 YNL327W EGT2 hom Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
0.092 1.08E-7 YMR125W STO1 hom Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80