HIPHOP chemogenomics database

YGR087C / PDC6

Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR087C / PDC6

Click on Significant Values for Screen Details

Top fitness defect scores for YGR087C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2056	5235370	7.02	200.0 µM	1.09E-13		7	1.14E-12
2	SGTC_1616	st002734	4.66	56.1 µM	5.70E-7		12	1.55E-6
3	SGTC_2586	curcumin	4.65	80.0 µM	6.13E-7	iron homeostasis	37	1.65E-6
4	SGTC_2827	7993847	4.29	71.4 µM	3.94E-6		16	9.08E-6
5	SGTC_3305	9127027	4.25	53.8 µM	4.80E-6		11	1.09E-5
6	SGTC_2527	2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone	3.99	63.6 µM	1.58E-5		39	3.25E-5
7	SGTC_2564	betulinic acid	3.87	100.0 µM	2.81E-5		32	5.50E-5
8	SGTC_3039	9090270	3.83	49.5 µM	3.33E-5	RPP1 & pyrimidine depletion	12	6.42E-5
9	SGTC_3303	9125618	3.78	40.6 µM	4.08E-5		53	7.73E-5
10	SGTC_108	0509-0257	3.66	621.1 µM	7.08E-5		64	1.28E-4
11	SGTC_1726	st035556	3.63	14.6 µM	7.81E-5		46	1.40E-4
12	SGTC_2049	5262831	3.57	67.2 µM	1.01E-4		40	1.78E-4
13	SGTC_1133	3473-0247	3.57	50.0 µM	1.02E-4	RSC complex & mRNA processing	69	1.79E-4
14	SGTC_274	sirtinol	3.51	40.1 µM	1.29E-4		35	2.22E-4
15	SGTC_2968	9090663	3.47	33.4 µM	1.51E-4		50	2.57E-4
16	SGTC_1834	st055981	3.40	52.8 µM	2.05E-4	RPP1 & pyrimidine depletion	52	3.41E-4
17	SGTC_1323	1348-1351	3.39	11.2 µM	2.14E-4		20	3.55E-4
18	SGTC_2933	9026794	3.36	32.5 µM	2.33E-4		50	3.83E-4
19	SGTC_229	benomyl	3.29	22.9 µM	3.06E-4	tubulin folding & SWR complex	49	4.93E-4
20	SGTC_1341	1486-1360	3.28	280.0 µM	3.20E-4		51	5.13E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.148	7.08E-18	YKL189W	HYM1	het	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.113	5.62E-11	YOR019W	YOR019W	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.112	9.40E-11	YDR333C	RQC1	hom	Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.110	1.43E-10	YMR192W	GYL1	hom	Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107	5.90E-10	YOR329C	SCD5	het	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.105	1.05E-9	YLR124W_d	YLR124W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.102	3.63E-9	YLL019C	KNS1	hom	Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.098	1.35E-8	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.094	4.89E-8	YLR285W	NNT1	hom	S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.094	5.37E-8	YOR233W	KIN4	hom	Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.089	2.27E-7	YNR071C_p	YNR071C_p	hom	Putative aldose 1-epimerase
0.089	2.36E-7	YGL065C	ALG2	het	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
0.085	7.68E-7	YCR017C	CWH43	hom	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.084	1.18E-6	YKL153W_d	YKL153W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.083	1.38E-6	YHL015W-A_p	YHL015W-A_p	hom	Putative protein of unknown function