YGR088W / CTT1

Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR088W / CTT1

Click on Significant Values for Screen Details ID:SGTC_13|Compound:0199-0087|FD-Score:-6.45|P-value:3.88E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.17|P-value:1.34E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-2.74|P-value:8.33E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-2.77|P-value:7.28E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:2.70|P-value:7.06E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:2.74|P-value:6.05E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.40|P-value:3.01E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.71|P-value:6.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.32|P-value:6.47E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.84|P-value:5.43E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.69|P-value:7.46E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.74|P-value:8.28E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.11|P-value:1.19E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.58|P-value:1.81E-5 ID:SGTC_1816|Compound:st051957|FD-Score:-2.85|P-value:5.36E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.03|P-value:1.73E-4 ID:SGTC_2128|Compound:5255449|FD-Score:2.78|P-value:5.09E-4 ID:SGTC_2138|Compound:5575593|FD-Score:2.83|P-value:4.19E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.07|P-value:8.47E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-3.03|P-value:2.47E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-3.64|P-value:1.32E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.97|P-value:2.30E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-7.18|P-value:4.28E-17 ID:SGTC_3092|Compound:9117248|FD-Score:-2.93|P-value:3.73E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.47|P-value:1.22E-7 ID:SGTC_3099|Compound:9120367|FD-Score:-4.75|P-value:1.98E-8 ID:SGTC_3298|Compound:9116858|FD-Score:-2.86|P-value:5.00E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.75|P-value:7.76E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.01|P-value:2.71E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.44|P-value:2.47E-5 ID:SGTC_13|Compound:0199-0087|FD-Score:-6.45|P-value:3.88E-14 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.17|P-value:1.34E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-2.74|P-value:8.33E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:-2.77|P-value:7.28E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:2.70|P-value:7.06E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:2.74|P-value:6.05E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.40|P-value:3.01E-5 ID:SGTC_1257|Compound:0669-0121|FD-Score:2.71|P-value:6.80E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.32|P-value:6.47E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-2.84|P-value:5.43E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:2.69|P-value:7.46E-4 ID:SGTC_1683|Compound:st010134|FD-Score:-2.74|P-value:8.28E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.11|P-value:1.19E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.58|P-value:1.81E-5 ID:SGTC_1816|Compound:st051957|FD-Score:-2.85|P-value:5.36E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.03|P-value:1.73E-4 ID:SGTC_2128|Compound:5255449|FD-Score:2.78|P-value:5.09E-4 ID:SGTC_2138|Compound:5575593|FD-Score:2.83|P-value:4.19E-4 ID:SGTC_2935|Compound:9038016|FD-Score:4.07|P-value:8.47E-7 ID:SGTC_2939|Compound:9044578|FD-Score:-3.03|P-value:2.47E-4 ID:SGTC_3079|Compound:9117512|FD-Score:-3.64|P-value:1.32E-5 ID:SGTC_3081|Compound:9117243|FD-Score:2.97|P-value:2.30E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-7.18|P-value:4.28E-17 ID:SGTC_3092|Compound:9117248|FD-Score:-2.93|P-value:3.73E-4 ID:SGTC_3094|Compound:9117742|FD-Score:-4.47|P-value:1.22E-7 ID:SGTC_3099|Compound:9120367|FD-Score:-4.75|P-value:1.98E-8 ID:SGTC_3298|Compound:9116858|FD-Score:-2.86|P-value:5.00E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.75|P-value:7.76E-4 ID:SGTC_3326|Compound:9140064|FD-Score:-3.01|P-value:2.71E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.44|P-value:2.47E-5

Top fitness defect scores for YGR088W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2935 9038016 4.07 30.0 µM 8.47E-7 18 2.38E-5
2 SGTC_3328 9140624 3.44 29.0 µM 2.47E-5 31 2.89E-4
3 SGTC_1125 tnp00248 3.40 1.3 µM 3.01E-5 61 3.34E-4
4 SGTC_1749 st037932 3.11 54.2 µM 1.19E-4 55 9.25E-4
5 SGTC_2125 5246583 3.03 200.0 µM 1.73E-4 tubulin folding & SWR complex 98 0.00122
6 SGTC_3081 9117243 2.97 49.5 µM 2.30E-4 fatty acid desaturase (OLE1) 56 0.00151
7 SGTC_2138 5575593 2.83 77.7 µM 4.19E-4 54 0.00236
8 SGTC_2128 5255449 2.78 168.5 µM 5.09E-4 102 0.00272
9 SGTC_1024 4507-0395 2.74 26.0 µM 6.05E-4 TSC3-RPN4 97 0.00310
10 SGTC_1257 0669-0121 2.71 16.0 µM 6.80E-4 109 0.00338
11 SGTC_790 1575-0012 2.70 79.1 µM 7.06E-4 TSC3-RPN4 105 0.00348
12 SGTC_1585 2',4'-dihydroxychalcone 2.69 10.4 µM 7.46E-4 104 0.00362
13 SGTC_2809 7964133 2.54 13.0 µM 0.00131 60S ribosome export 165 0.00552
14 SGTC_2176 5809774 2.51 34.0 µM 0.00146 mitochondrial processes 89 0.00598
15 SGTC_2576 guaiol 2.51 23.1 µM 0.00150 131 0.00610
16 SGTC_2567 aureobasidin a 2.50 60.0 nM 0.00155 218 0.00626
17 SGTC_684 1140-0066 2.48 328.0 µM 0.00165 Golgi 161 0.00654
18 SGTC_2930 9013230 2.48 14.9 µM 0.00168 heme biosynthesis & mitochondrial translocase 161 0.00664
19 SGTC_622 1348-1566 2.45 26.3 µM 0.00185 125 0.00713
20 SGTC_2791 5663188 2.42 71.4 µM 0.00206 RPP1 & pyrimidine depletion 125 0.00772

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.140 4.40E-16 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.122 1.25E-12 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.119 5.26E-12 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.113 4.63E-11 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.111 1.34E-10 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.109 2.08E-10 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.107 4.99E-10 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.104 1.53E-9 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.103 1.99E-9 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.103 2.06E-9 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.103 2.08E-9 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.097 1.57E-8 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.096 2.25E-8 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.095 3.34E-8 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.095 3.65E-8 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability