HIPHOP chemogenomics database
YGR093W_p 
Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YGR093W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.139 | 7.84E-16 | YOR093C_p | YOR093C_p | hom | Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents |
| 0.132 | 1.92E-14 | YOR083W | WHI5 | hom | Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 |
| 0.127 | 1.78E-13 | YDR191W | HST4 | hom | Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism |
| 0.119 | 5.33E-12 | YOL141W | PPM2 | hom | AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p |
| 0.112 | 6.73E-11 | YPL121C | MEI5 | hom | Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p |
| 0.111 | 1.16E-10 | YGR003W | CUL3 | hom | Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 |
| 0.109 | 2.14E-10 | YBR071W | YBR071W | hom | Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking |
| 0.105 | 1.10E-9 | YGL081W_p | YGL081W_p | hom | Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis |
| 0.100 | 5.97E-9 | YKL162C_p | YKL162C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion |
| 0.099 | 9.83E-9 | YBL036C | YBL036C | hom | Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS |
| 0.098 | 1.48E-8 | YKL129C | MYO3 | hom | One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization |
| 0.091 | 1.44E-7 | YGL235W_p | YGL235W_p | hom | Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 |
| 0.085 | 7.51E-7 | YDL224C | WHI4 | hom | Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication |
| 0.084 | 1.05E-6 | YKL201C | MNN4 | hom | Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication |
| 0.081 | 2.64E-6 | YGR066C_p | YGR066C_p | hom | Putative protein of unknown function |