YGR123C / PPT1

Protein serine/threonine phosphatase, regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR123C / PPT1

Click on Significant Values for Screen Details ID:SGTC_349|Compound:k015-0014|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.34|P-value:3.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.71|P-value:7.56E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:3.94|P-value:2.90E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.61|P-value:4.95E-9 ID:SGTC_470|Compound:aa-861|FD-Score:-3.01|P-value:9.64E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.40|P-value:2.61E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.18|P-value:5.77E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.09|P-value:7.99E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.13|P-value:6.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.78|P-value:1.33E-9 ID:SGTC_1591|Compound:genipin|FD-Score:-3.72|P-value:6.23E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-4.18|P-value:8.33E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-3.84|P-value:3.72E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.76|P-value:6.05E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.12|P-value:7.43E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.44|P-value:2.80E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-4.29|P-value:4.88E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.22|P-value:4.41E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.08|P-value:7.31E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.43|P-value:1.12E-8 ID:SGTC_2428|Compound:5615643|FD-Score:3.21|P-value:5.37E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.16|P-value:5.53E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.98|P-value:2.39E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.69|P-value:8.19E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.14|P-value:1.15E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_3150|Compound:9097574|FD-Score:4.90|P-value:2.77E-7 ID:SGTC_349|Compound:k015-0014|FD-Score:3.44|P-value:2.25E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:3.34|P-value:3.28E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:4.71|P-value:7.56E-7 ID:SGTC_373|Compound:0844-0104|FD-Score:3.94|P-value:2.90E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:5.61|P-value:4.95E-9 ID:SGTC_470|Compound:aa-861|FD-Score:-3.01|P-value:9.64E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.40|P-value:2.61E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.18|P-value:5.77E-8 ID:SGTC_612|Compound:0302-0167|FD-Score:3.03|P-value:9.96E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:3.09|P-value:8.22E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.09|P-value:7.99E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.13|P-value:6.18E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-5.78|P-value:1.33E-9 ID:SGTC_1591|Compound:genipin|FD-Score:-3.72|P-value:6.23E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-4.18|P-value:8.33E-6 ID:SGTC_1782|Compound:st039423|FD-Score:-3.84|P-value:3.72E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.76|P-value:6.05E-5 ID:SGTC_1885|Compound:st057546|FD-Score:3.12|P-value:7.43E-4 ID:SGTC_1907|Compound:st060210|FD-Score:4.44|P-value:2.80E-6 ID:SGTC_2017|Compound:5132927|FD-Score:-4.29|P-value:4.88E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.22|P-value:4.41E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.08|P-value:7.31E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-5.43|P-value:1.12E-8 ID:SGTC_2428|Compound:5615643|FD-Score:3.21|P-value:5.37E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.16|P-value:5.53E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.98|P-value:2.39E-5 ID:SGTC_2794|Compound:7785382|FD-Score:3.69|P-value:8.19E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.14|P-value:1.15E-5 ID:SGTC_3147|Compound:9097027|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_3150|Compound:9097574|FD-Score:4.90|P-value:2.77E-7

Top fitness defect scores for YGR123C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_439 amiodarone 5.61 34.4 µM 4.95E-9 NEO1-PIK1 53 1.04E-8
2 SGTC_607 4491-0986 5.18 66.8 µM 5.77E-8 heme requiring 7 1.08E-7
3 SGTC_3150 9097574 4.90 49.5 µM 2.77E-7 5 4.85E-7
4 SGTC_358 0075-0058 4.71 9.4 µM 7.56E-7 33 1.26E-6
5 SGTC_1907 st060210 4.44 83.7 µM 2.80E-6 10 4.41E-6
6 SGTC_2921 7974240 4.14 10.7 µM 1.15E-5 47 1.70E-5
7 SGTC_2692 st077426 3.98 47.7 µM 2.39E-5 23 3.42E-5
8 SGTC_373 0844-0104 3.94 25.9 µM 2.90E-5 ERAD & cell cycle 47 4.12E-5
9 SGTC_1800 st050079 3.76 29.1 µM 6.05E-5 NEO1-PIK1 130 8.34E-5
10 SGTC_2794 7785382 3.69 27.3 µM 8.19E-5 48 1.11E-4
11 SGTC_3147 9097027 3.50 49.5 µM 1.74E-4 39 2.30E-4
12 SGTC_349 k015-0014 3.44 24.0 µM 2.25E-4 40 2.93E-4
13 SGTC_564 3555-0129 3.40 330.0 µM 2.61E-4 13 3.37E-4
14 SGTC_355 1311-2252 3.34 105.0 µM 3.28E-4 44 4.21E-4
15 SGTC_2428 5615643 3.21 7.8 µM 5.37E-4 53 6.75E-4
16 SGTC_1885 st057546 3.12 99.9 µM 7.43E-4 47 9.20E-4
17 SGTC_1083 didemethylchlorpromazine sulfoxide 3.09 707.4 nM 7.99E-4 redox potentiating 139 9.87E-4
18 SGTC_998 3996-0085 3.09 177.0 µM 8.22E-4 53 0.00101
19 SGTC_612 0302-0167 3.03 22.4 µM 9.96E-4 copper-dependent oxidative stress 80 0.00122
20 SGTC_660 4031-1742 3.03 102.0 µM 0.00101 redox potentiating 98 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 3.69E-37 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.183 1.99E-26 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.176 1.08E-24 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.175 1.29E-24 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.175 1.68E-24 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.169 9.28E-23 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.168 1.27E-22 YJL050W MTR4 het ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
0.165 6.49E-22 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.163 2.76E-21 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.162 5.74E-21 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.160 1.06E-20 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.159 1.68E-20 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.157 5.54E-20 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.149 3.18E-18 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.149 3.54E-18 YHR131C_p YHR131C_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study