YGR127W_p

Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR127W / YGR127W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:2.86|P-value:8.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.98|P-value:5.33E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.22|P-value:1.89E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.24|P-value:1.83E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.09|P-value:3.27E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:2.98|P-value:5.32E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.02|P-value:4.49E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.40|P-value:8.70E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-2.98|P-value:5.10E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.18|P-value:1.95E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:5.23|P-value:4.26E-9 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:3.05E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.83|P-value:9.28E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.98|P-value:2.17E-11 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:1.04E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.82|P-value:9.77E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.08|P-value:3.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.12|P-value:2.88E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.49|P-value:6.31E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.92|P-value:6.67E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.83|P-value:1.25E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.03|P-value:4.10E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.88|P-value:9.18E-6 ID:SGTC_1939|Compound:st074455|FD-Score:2.87|P-value:8.01E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.67|P-value:2.71E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.11|P-value:3.01E-6 ID:SGTC_2159|Compound:5658611|FD-Score:2.86|P-value:8.44E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.72|P-value:9.67E-8 ID:SGTC_2192|Compound:5915882|FD-Score:-2.83|P-value:8.95E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.19|P-value:2.18E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-2.93|P-value:6.16E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.00|P-value:4.63E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.56|P-value:4.35E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-2.87|P-value:7.53E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:1.92E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.48|P-value:6.48E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.14|P-value:2.61E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.87|P-value:7.99E-4 ID:SGTC_2793|Compound:7325131|FD-Score:5.53|P-value:6.00E-10 ID:SGTC_2796|Compound:7949634|FD-Score:11.40|P-value:1.27E-36 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:7.96E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.48|P-value:6.52E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.19|P-value:2.25E-4 ID:SGTC_2889|Compound:9059656|FD-Score:2.89|P-value:7.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.06|P-value:4.02E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.06|P-value:3.67E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.27|P-value:1.61E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-2.82|P-value:9.23E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.41|P-value:8.74E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-3.18|P-value:2.20E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:2.86|P-value:8.19E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.98|P-value:5.33E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.22|P-value:1.89E-4 ID:SGTC_196|Compound:k015-0023|FD-Score:3.24|P-value:1.83E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:-3.09|P-value:3.27E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:2.98|P-value:5.32E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.02|P-value:4.49E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:-3.40|P-value:8.70E-5 ID:SGTC_272|Compound:doxorubicin|FD-Score:-2.98|P-value:5.10E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.18|P-value:1.95E-6 ID:SGTC_737|Compound:1950-0117|FD-Score:5.23|P-value:4.26E-9 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:3.05E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:2.83|P-value:9.28E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.98|P-value:2.17E-11 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.10|P-value:3.25E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.86|P-value:1.04E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:2.82|P-value:9.77E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.08|P-value:3.36E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.12|P-value:2.88E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:3.49|P-value:6.31E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:2.92|P-value:6.67E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.83|P-value:1.25E-5 ID:SGTC_1841|Compound:st054148|FD-Score:-3.03|P-value:4.10E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.88|P-value:9.18E-6 ID:SGTC_1939|Compound:st074455|FD-Score:2.87|P-value:8.01E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.67|P-value:2.71E-5 ID:SGTC_2021|Compound:4019055|FD-Score:4.11|P-value:3.01E-6 ID:SGTC_2159|Compound:5658611|FD-Score:2.86|P-value:8.44E-4 ID:SGTC_2161|Compound:5662504|FD-Score:-4.72|P-value:9.67E-8 ID:SGTC_2192|Compound:5915882|FD-Score:-2.83|P-value:8.95E-4 ID:SGTC_2239|Compound:6685329|FD-Score:-3.19|P-value:2.18E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-2.93|P-value:6.16E-4 ID:SGTC_2301|Compound:7769476|FD-Score:-3.00|P-value:4.63E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-3.56|P-value:4.35E-5 ID:SGTC_2367|Compound:9070478|FD-Score:-2.87|P-value:7.53E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:1.92E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:3.48|P-value:6.48E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:4.14|P-value:2.61E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:2.87|P-value:7.99E-4 ID:SGTC_2793|Compound:7325131|FD-Score:5.53|P-value:6.00E-10 ID:SGTC_2796|Compound:7949634|FD-Score:11.40|P-value:1.27E-36 ID:SGTC_2800|Compound:7887935|FD-Score:3.92|P-value:7.96E-6 ID:SGTC_2803|Compound:7707263|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.48|P-value:6.52E-5 ID:SGTC_2880|Compound:9042983|FD-Score:3.19|P-value:2.25E-4 ID:SGTC_2889|Compound:9059656|FD-Score:2.89|P-value:7.43E-4 ID:SGTC_2916|Compound:7875993|FD-Score:4.06|P-value:4.02E-6 ID:SGTC_3006|Compound:9075424|FD-Score:-3.06|P-value:3.67E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.27|P-value:1.61E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-2.82|P-value:9.23E-4 ID:SGTC_3271|Compound:9137798|FD-Score:3.41|P-value:8.74E-5 ID:SGTC_3294|Compound:9122953|FD-Score:-3.18|P-value:2.20E-4

Top fitness defect scores for YGR127W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2796 7949634 11.40 45.5 µM 1.27E-36 1 1.48E-30
2 SGTC_2793 7325131 5.53 81.8 µM 6.00E-10 6 1.65E-8
3 SGTC_737 1950-0117 5.23 57.9 µM 4.26E-9 6 8.36E-8
4 SGTC_2724 maprotiline 4.14 69.6 µM 2.61E-6 ERG2 12 1.73E-5
5 SGTC_2021 4019055 4.11 173.0 µM 3.01E-6 endomembrane recycling 114 1.94E-5
6 SGTC_2916 7875993 4.06 68.8 µM 4.02E-6 23 2.47E-5
7 SGTC_2800 7887935 3.92 81.8 µM 7.96E-6 RPP1 & pyrimidine depletion 34 4.37E-5
8 SGTC_1831 st055328 3.83 12.0 µM 1.25E-5 heme biosynthesis & mitochondrial translocase 30 6.34E-5
9 SGTC_2014 4013930 3.67 200.0 µM 2.71E-5 50 1.21E-4
10 SGTC_1579 chlormadinone acetate 3.49 49.4 µM 6.31E-5 17 2.45E-4
11 SGTC_2673 kobusone 3.48 100.0 µM 6.48E-5 10 2.51E-4
12 SGTC_2816 7982706 3.48 58.4 µM 6.52E-5 azole & statin 73 2.52E-4
13 SGTC_3271 9137798 3.41 49.5 µM 8.74E-5 12 3.22E-4
14 SGTC_3207 9114163 3.27 49.5 µM 1.61E-4 61 5.36E-4
15 SGTC_196 k015-0023 3.24 18.1 µM 1.83E-4 PDR1 45 5.97E-4
16 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.23 3.7 µM 1.92E-4 163 6.21E-4
17 SGTC_2880 9042983 3.19 58.4 µM 2.25E-4 fatty acid desaturase (OLE1) 56 7.08E-4
18 SGTC_740 k014-0057 3.12 261.0 µM 3.05E-4 60 9.14E-4
19 SGTC_1091 telmisartan 3.10 47.6 µM 3.25E-4 45 9.64E-4
20 SGTC_257 daunorubicin 3.02 18.5 µM 4.49E-4 anthracycline transcription coupled DNA repair 47 0.00126

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 8.33E-37 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.191 6.89E-29 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.182 2.92E-26 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.181 3.58E-26 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.168 1.49E-22 YLR267W_p BOP2_p hom Protein of unknown function
0.165 5.66E-22 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.165 6.24E-22 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.165 6.93E-22 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.163 1.96E-21 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.162 4.61E-21 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.161 5.61E-21 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.156 1.01E-19 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.155 1.37E-19 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.153 5.49E-19 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.152 1.03E-18 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification