YGR132C / PHB1

Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR132C / PHB1

Click on Significant Values for Screen Details ID:SGTC_74|Compound:000s-0487|FD-Score:-3.50|P-value:8.97E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.92|P-value:9.10E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.26|P-value:2.56E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.22|P-value:2.54E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-3.10|P-value:4.53E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.29|P-value:2.14E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.26|P-value:6.72E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:4.23|P-value:2.48E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:9.57|P-value:2.98E-25 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.36|P-value:1.60E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.14|P-value:3.96E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.21|P-value:2.53E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.92|P-value:7.75E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.45|P-value:1.97E-9 ID:SGTC_932|Compound:2857-0803|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.61|P-value:4.85E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.44|P-value:9.87E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.85|P-value:1.85E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.20|P-value:3.12E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.91|P-value:9.24E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.00|P-value:6.58E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.06|P-value:4.67E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.24|P-value:2.68E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.94|P-value:1.04E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.02|P-value:5.35E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-4.37|P-value:1.45E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.05|P-value:5.59E-4 ID:SGTC_2075|Compound:5212009|FD-Score:2.97|P-value:6.57E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-2.91|P-value:9.30E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.29|P-value:2.19E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.16|P-value:3.60E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.04|P-value:5.12E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.05|P-value:4.91E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.29|P-value:2.16E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.03|P-value:5.89E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.38|P-value:1.27E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.86|P-value:1.82E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.51|P-value:8.40E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.27|P-value:2.36E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.54|P-value:6.42E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.52|P-value:5.36E-7 ID:SGTC_2919|Compound:7978188|FD-Score:2.95|P-value:7.12E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.46|P-value:8.99E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.03|P-value:6.53E-6 ID:SGTC_2991|Compound:9074669|FD-Score:2.99|P-value:6.01E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.26|P-value:2.39E-4 ID:SGTC_3217|Compound:9129673|FD-Score:2.90|P-value:8.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.51|P-value:5.64E-7 ID:SGTC_3329|Compound:9141233|FD-Score:3.14|P-value:3.47E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.50|P-value:8.97E-5 ID:SGTC_139|Compound:0099-0334|FD-Score:-2.92|P-value:9.10E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-4.26|P-value:2.56E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:4.22|P-value:2.54E-6 ID:SGTC_264|Compound:promethazine|FD-Score:-3.10|P-value:4.53E-4 ID:SGTC_311|Compound:1315-0136|FD-Score:2.92|P-value:8.02E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.15|P-value:3.34E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:-3.29|P-value:2.14E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:5.26|P-value:6.72E-9 ID:SGTC_539|Compound:4859-0462|FD-Score:4.23|P-value:2.48E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:9.57|P-value:2.98E-25 ID:SGTC_594|Compound:1487-1584|FD-Score:-3.36|P-value:1.60E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.14|P-value:3.96E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.21|P-value:2.53E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:2.92|P-value:7.75E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.45|P-value:1.97E-9 ID:SGTC_932|Compound:2857-0803|FD-Score:3.28|P-value:1.93E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.61|P-value:4.85E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.44|P-value:9.87E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:-3.85|P-value:1.85E-5 ID:SGTC_1484|Compound:3473-2379|FD-Score:-3.20|P-value:3.12E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.91|P-value:9.24E-4 ID:SGTC_1614|Compound:st002383|FD-Score:-3.00|P-value:6.58E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.06|P-value:4.67E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-3.24|P-value:2.68E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.94|P-value:1.04E-5 ID:SGTC_1833|Compound:st055984|FD-Score:3.02|P-value:5.35E-4 ID:SGTC_1839|Compound:st053978|FD-Score:-4.37|P-value:1.45E-6 ID:SGTC_1947|Compound:st076332|FD-Score:-3.05|P-value:5.59E-4 ID:SGTC_2075|Compound:5212009|FD-Score:2.97|P-value:6.57E-4 ID:SGTC_2135|Compound:5326629|FD-Score:-2.91|P-value:9.30E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-4.29|P-value:2.19E-6 ID:SGTC_2349|Compound:9023730|FD-Score:3.40|P-value:1.17E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.16|P-value:3.60E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.04|P-value:5.12E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.99|P-value:6.03E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.05|P-value:4.91E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.29|P-value:2.16E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.03|P-value:5.89E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.38|P-value:1.27E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.86|P-value:1.82E-5 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.51|P-value:8.40E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.27|P-value:2.36E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.01|P-value:6.43E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.54|P-value:6.42E-5 ID:SGTC_2794|Compound:7785382|FD-Score:4.52|P-value:5.36E-7 ID:SGTC_2919|Compound:7978188|FD-Score:2.95|P-value:7.12E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.46|P-value:8.99E-5 ID:SGTC_2989|Compound:9073649|FD-Score:4.03|P-value:6.53E-6 ID:SGTC_2991|Compound:9074669|FD-Score:2.99|P-value:6.01E-4 ID:SGTC_3154|Compound:9100113|FD-Score:-3.26|P-value:2.39E-4 ID:SGTC_3217|Compound:9129673|FD-Score:2.90|P-value:8.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.51|P-value:5.64E-7 ID:SGTC_3329|Compound:9141233|FD-Score:3.14|P-value:3.47E-4

Top fitness defect scores for YGR132C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_545 4218-0007 9.57 221.0 µM 2.98E-25 1 5.27E-22
2 SGTC_852 0418-0143 5.45 439.0 µM 1.97E-9 calcium & mitochondrial duress 34 2.46E-8
3 SGTC_536 3852-0578 5.26 10.6 µM 6.72E-9 6 7.11E-8
4 SGTC_2794 7785382 4.52 27.3 µM 5.36E-7 17 3.14E-6
5 SGTC_3218 9131285 4.51 49.5 µM 5.64E-7 endomembrane recycling 28 3.28E-6
6 SGTC_539 4859-0462 4.23 2.5 µM 2.48E-6 RNA pol III & RNase P/MRP 18 1.18E-5
7 SGTC_236 1509-0011 4.22 5.3 µM 2.54E-6 366 1.21E-5
8 SGTC_2989 9073649 4.03 71.4 µM 6.53E-6 35 2.74E-5
9 SGTC_1794 st048918 3.94 76.9 µM 1.04E-5 12 4.11E-5
10 SGTC_940 3232-1287 3.61 54.8 µM 4.85E-5 NEO1 51 1.56E-4
11 SGTC_2713 st079149 3.54 53.4 µM 6.42E-5 35 1.98E-4
12 SGTC_2987 9018338 3.46 71.4 µM 8.99E-5 RPP1 & pyrimidine depletion 38 2.66E-4
13 SGTC_1215 3852-0577 3.44 11.2 µM 9.87E-5 27 2.88E-4
14 SGTC_2349 9023730 3.40 187.1 µM 1.17E-4 56 3.34E-4
15 SGTC_2487 5918373 3.38 44.0 µM 1.27E-4 35 3.59E-4
16 SGTC_932 2857-0803 3.28 154.0 µM 1.93E-4 52 5.15E-4
17 SGTC_769 0302-0231 3.21 76.0 µM 2.53E-4 95 6.53E-4
18 SGTC_322 k048-0136 3.15 19.3 µM 3.34E-4 RSC & ERG11 37 8.29E-4
19 SGTC_3329 9141233 3.14 27.6 µM 3.47E-4 33 8.57E-4
20 SGTC_1635 st007035 3.06 42.4 µM 4.67E-4 288 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.173 6.88E-24 YGR231C PHB2 hom Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
0.168 1.32E-22 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.158 3.51E-20 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.157 7.39E-20 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.150 2.51E-18 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.148 7.72E-18 YNR029C_p YNR029C_p hom Putative protein of unknown function, deletion confers reduced fitness in saline
0.140 3.97E-16 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.139 6.07E-16 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.139 6.43E-16 YNL046W_p YNL046W_p hom Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.136 3.12E-15 YDL142C CRD1 hom Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis
0.135 4.68E-15 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.134 6.12E-15 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.133 9.64E-15 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.128 1.08E-13 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.128 1.31E-13 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p