YGR134W / CAF130

Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR134W / CAF130

Click on Significant Values for Screen Details ID:SGTC_78|Compound:0336-0123|FD-Score:-3.74|P-value:1.33E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.09|P-value:8.39E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:4.73|P-value:8.90E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.56|P-value:1.55E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.55|P-value:1.60E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.87|P-value:8.09E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.20|P-value:5.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.38|P-value:4.98E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.39|P-value:2.84E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.94|P-value:3.27E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.81|P-value:5.64E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.33|P-value:3.58E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.41|P-value:4.60E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.32|P-value:3.67E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.76|P-value:7.77E-7 ID:SGTC_874|Compound:0599-0792|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.15|P-value:6.82E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.63|P-value:1.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.81|P-value:6.07E-7 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.32|P-value:6.23E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.18|P-value:6.16E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:8.82|P-value:4.62E-19 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.16|P-value:1.31E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.96|P-value:3.00E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.40|P-value:4.72E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.32|P-value:6.31E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.43|P-value:3.79E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.32|P-value:6.33E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.42|P-value:2.56E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.72|P-value:7.48E-12 ID:SGTC_2461|Compound:5755302|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.50|P-value:2.70E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.15|P-value:1.34E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.45|P-value:2.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.62|P-value:1.57E-6 ID:SGTC_2933|Compound:9026794|FD-Score:4.02|P-value:2.35E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.28|P-value:7.15E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.28|P-value:7.05E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.31|P-value:6.36E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.88|P-value:3.80E-9 ID:SGTC_3314|Compound:9135860|FD-Score:6.14|P-value:3.37E-10 ID:SGTC_3315|Compound:9136395|FD-Score:4.32|P-value:6.20E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:-3.74|P-value:1.33E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:3.09|P-value:8.39E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.60|P-value:1.33E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:4.73|P-value:8.90E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:4.00|P-value:2.60E-5 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.56|P-value:1.55E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:3.55|P-value:1.60E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.87|P-value:8.09E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.20|P-value:5.76E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-3.38|P-value:4.98E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.39|P-value:2.84E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.94|P-value:3.27E-5 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:4.95E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.81|P-value:5.64E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:3.33|P-value:3.58E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.41|P-value:4.60E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.32|P-value:3.67E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:4.76|P-value:7.77E-7 ID:SGTC_874|Compound:0599-0792|FD-Score:3.35|P-value:3.32E-4 ID:SGTC_875|Compound:0709-0210|FD-Score:3.15|P-value:6.82E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.13|P-value:7.31E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.63|P-value:1.18E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:4.81|P-value:6.07E-7 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.32|P-value:6.23E-6 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.18|P-value:6.16E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.65|P-value:1.06E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.20|P-value:5.79E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:8.82|P-value:4.62E-19 ID:SGTC_1444|Compound:4112-3581|FD-Score:4.16|P-value:1.31E-5 ID:SGTC_1509|Compound:1326-1131|FD-Score:3.16|P-value:6.51E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.96|P-value:3.00E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.40|P-value:4.72E-4 ID:SGTC_1734|Compound:st037168|FD-Score:4.32|P-value:6.31E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_1912|Compound:st060209|FD-Score:4.43|P-value:3.79E-6 ID:SGTC_2034|Compound:5197015|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_2090|Compound:5301565|FD-Score:-3.32|P-value:6.33E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.42|P-value:2.56E-4 ID:SGTC_2361|Compound:9034121|FD-Score:3.19|P-value:5.82E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.72|P-value:7.48E-12 ID:SGTC_2461|Compound:5755302|FD-Score:3.30|P-value:3.98E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:4.50|P-value:2.70E-6 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.15|P-value:1.34E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.45|P-value:2.31E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.62|P-value:1.57E-6 ID:SGTC_2933|Compound:9026794|FD-Score:4.02|P-value:2.35E-5 ID:SGTC_2934|Compound:9036370|FD-Score:-3.28|P-value:7.15E-4 ID:SGTC_3028|Compound:9087778|FD-Score:-3.28|P-value:7.05E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.31|P-value:6.36E-4 ID:SGTC_3211|Compound:9128781|FD-Score:-5.88|P-value:3.80E-9 ID:SGTC_3314|Compound:9135860|FD-Score:6.14|P-value:3.37E-10 ID:SGTC_3315|Compound:9136395|FD-Score:4.32|P-value:6.20E-6

Top fitness defect scores for YGR134W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1424 4048-1941 8.82 275.0 µM 4.62E-19 1 5.54E-19
2 SGTC_2405 ticlatone 6.72 3.5 µM 7.48E-12 22 9.37E-12
3 SGTC_3314 9135860 6.14 59.4 µM 3.37E-10 3 4.24E-10
4 SGTC_1226 3909-7979 4.81 35.4 µM 6.07E-7 26 7.57E-7
5 SGTC_865 0488-0499 4.76 301.0 µM 7.77E-7 9 9.69E-7
6 SGTC_177 1327-0068 4.73 8.4 µM 8.90E-7 33 1.11E-6
7 SGTC_2929 9013348 4.62 24.6 µM 1.57E-6 11 1.95E-6
8 SGTC_2533 agelasine 4.50 13.7 µM 2.70E-6 ERG2 37 3.35E-6
9 SGTC_1912 st060209 4.43 90.8 µM 3.79E-6 30 4.70E-6
10 SGTC_3315 9136395 4.32 68.5 µM 6.20E-6 6 7.67E-6
11 SGTC_1227 3909-8010 4.32 46.6 µM 6.23E-6 9 7.71E-6
12 SGTC_1734 st037168 4.32 69.4 µM 6.31E-6 14 7.81E-6
13 SGTC_1444 4112-3581 4.16 28.0 µM 1.31E-5 6 1.62E-5
14 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.15 66.7 µM 1.34E-5 16 1.65E-5
15 SGTC_2933 9026794 4.02 32.5 µM 2.35E-5 16 2.89E-5
16 SGTC_218 alverine citrate 4.00 93.8 µM 2.60E-5 fatty acid desaturase (OLE1) 31 3.20E-5
17 SGTC_1676 st018489 3.96 23.4 µM 3.00E-5 60S ribosome export 34 3.69E-5
18 SGTC_454 lyso-paf C-16 3.94 6.7 µM 3.27E-5 17 4.02E-5
19 SGTC_691 1548-0686 3.81 185.0 µM 5.64E-5 39 6.91E-5
20 SGTC_1271 0832-2808 3.65 169.0 µM 1.06E-4 21 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.249 1.85E-48 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.205 4.09E-33 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.185 3.98E-27 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.112 7.34E-11 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.105 9.12E-10 YKL090W CUE2 hom Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
0.105 9.32E-10 YHL042W_p YHL042W_p hom Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.100 6.94E-9 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.097 1.68E-8 YDL080C THI3 hom Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
0.092 1.10E-7 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.091 1.32E-7 YKL064W MNR2 hom Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
0.087 3.93E-7 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.086 5.74E-7 YKL072W STB6 hom Protein that binds Sin3p in a two-hybrid assay
0.086 6.28E-7 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.085 7.80E-7 YOR168W GLN4 het Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
0.085 8.19E-7 YPR012W_d YPR012W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene