HIPHOP chemogenomics database

YGR158C / MTR3

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGR158C / MTR3

Click on Significant Values for Screen Details

Top fitness defect scores for YGR158C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_617	3770-0098	16.60	35.0 µM	9.64E-57	exosome	2	6.52E-62	3.16
2	SGTC_242	5hr heat shock (37°C) + 5-fluorouracil	14.80	4.6 µM	7.91E-46	heat shock/prefoldin	4	5.64E-50	5.16
3	SGTC_1074	carmofur	13.10	3.8 µM	1.72E-36	exosome	3	9.21E-40	0.53
4	SGTC_423	5-fluorouracil	11.60	457.0 µM	7.07E-29	exosome	4	1.95E-31	2.32
5	SGTC_1698	5-fluorocytosine	8.42	1.1 µM	4.36E-16	exosome	5	1.89E-17	1.46
6	SGTC_3337	9144342	8.31	33.5 µM	1.01E-15		1	4.72E-17	1.40
7	SGTC_1077	5-fluorocytosine	7.95	377.0 nM	1.53E-14	exosome	8	9.22E-16	1.07
8	SGTC_610	4215-0184	7.08	155.0 µM	6.85E-12	exosome	7	7.30E-13	0.09
9	SGTC_2158	5657123	6.06	3.6 µM	3.65E-9		4	6.96E-10	0.31
10	SGTC_3084	9116877	5.70	49.5 µM	2.68E-8		1	6.15E-9	2.11
11	SGTC_2000	st075254	5.54	36.4 µM	6.21E-8		2	1.54E-8	1.39
12	SGTC_1889	st059080	5.48	5.2 µM	8.40E-8		1	2.14E-8	0.95
13	SGTC_1997	st073024	4.60	93.8 µM	5.64E-6		1	2.12E-6	0.55
14	SGTC_1992	st073643	4.49	23.3 µM	9.25E-6	mitochondrial processes	6	3.63E-6	0.13
15	SGTC_879	0831-1030	4.42	162.0 µM	1.22E-5		18	4.92E-6	0.25
16	SGTC_3324	9138759	4.35	60.8 µM	1.65E-5		4	6.81E-6	0.68
17	SGTC_261	5-fluorouridine	4.33	15.4 µM	1.78E-5	exosome	11	7.41E-6	0.28
18	SGTC_2940	9060638	4.28	45.9 µM	2.16E-5	amide catabolism	5	9.18E-6	0.35
19	SGTC_1276	0871-0068	4.27	94.2 µM	2.29E-5		4	9.75E-6	0.07
20	SGTC_832	4083-0019	4.19	164.0 µM	3.16E-5	translation	22	1.38E-5	0.02

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.599	0	YGR195W	SKI6	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
0.516	1.70E-227	YDL111C	RRP42	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)
0.500	4.19E-212	YOL021C	DIS3	het	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
0.385	4.74E-119	YDR280W	RRP45	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.373	1.53E-111	YPL044C_d	YPL044C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W
0.359	9.51E-103	YGR095C	RRP46	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.334	2.78E-88	YPL043W	NOP4	het	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
0.330	6.06E-86	YNL232W	CSL4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)
0.319	2.19E-80	YKL172W	EBP2	het	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering
0.310	8.38E-76	YPR142C_d	YPR142C_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing
0.276	6.49E-60	YPR143W	RRP15	het	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
0.237	5.24E-44	YNL061W	NOP2	het	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.219	1.51E-37	YNL002C	RLP7	het	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
0.208	4.52E-34	YHR069C	RRP4	het	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
0.189	2.26E-28	YNL140C_p	YNL140C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C