YGR161W-C_p

Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR161W-C / YGR161W-C

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:3.74|P-value:6.96E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.78|P-value:6.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.39|P-value:1.67E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:5.75E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-3.15|P-value:1.30E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:4.06|P-value:1.19E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:-2.99|P-value:2.57E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.12|P-value:8.91E-7 ID:SGTC_773|Compound:4358-1457|FD-Score:2.80|P-value:5.59E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.91|P-value:3.54E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.88|P-value:4.03E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.42|P-value:3.66E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.93|P-value:3.23E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.80|P-value:5.05E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.76|P-value:6.54E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.23|P-value:4.36E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.46|P-value:1.08E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.13|P-value:1.39E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.35|P-value:4.86E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.67|P-value:1.00E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.16|P-value:1.17E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.59|P-value:1.46E-5 ID:SGTC_2185|Compound:6113692|FD-Score:2.74|P-value:7.26E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2449|Compound:5812982|FD-Score:2.72|P-value:7.90E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.26|P-value:3.78E-7 ID:SGTC_2453|Compound:5731132|FD-Score:3.29|P-value:6.36E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.97|P-value:2.69E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.59|P-value:1.55E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-3.44|P-value:3.28E-5 ID:SGTC_2986|Compound:9022445|FD-Score:2.78|P-value:6.05E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.29|P-value:3.21E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.48|P-value:9.43E-8 ID:SGTC_2997|Compound:9067075|FD-Score:2.84|P-value:4.70E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.81|P-value:5.47E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-3.13|P-value:1.44E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.01|P-value:2.32E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.72|P-value:7.87E-4 ID:SGTC_37|Compound:0566-0070|FD-Score:3.74|P-value:6.96E-6 ID:SGTC_45|Compound:0kpi-0036|FD-Score:2.78|P-value:6.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.39|P-value:1.67E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:4.18|P-value:5.75E-7 ID:SGTC_264|Compound:promethazine|FD-Score:-3.15|P-value:1.30E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:4.06|P-value:1.19E-6 ID:SGTC_594|Compound:1487-1584|FD-Score:-2.99|P-value:2.57E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-4.12|P-value:8.91E-7 ID:SGTC_773|Compound:4358-1457|FD-Score:2.80|P-value:5.59E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:2.91|P-value:3.54E-4 ID:SGTC_848|Compound:0368-0089|FD-Score:2.88|P-value:4.03E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-3.42|P-value:3.66E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.93|P-value:3.23E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.80|P-value:5.05E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.76|P-value:6.54E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.23|P-value:4.36E-7 ID:SGTC_1455|Compound:4262-0120|FD-Score:4.46|P-value:1.08E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.13|P-value:1.39E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.35|P-value:4.86E-5 ID:SGTC_1717|Compound:st033143|FD-Score:3.67|P-value:1.00E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.16|P-value:1.17E-4 ID:SGTC_2139|Compound:5578692|FD-Score:3.59|P-value:1.46E-5 ID:SGTC_2185|Compound:6113692|FD-Score:2.74|P-value:7.26E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.00|P-value:2.54E-4 ID:SGTC_2449|Compound:5812982|FD-Score:2.72|P-value:7.90E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-4.26|P-value:3.78E-7 ID:SGTC_2453|Compound:5731132|FD-Score:3.29|P-value:6.36E-5 ID:SGTC_2847|Compound:9005661|FD-Score:2.97|P-value:2.69E-4 ID:SGTC_2979|Compound:9012552|FD-Score:-3.59|P-value:1.55E-5 ID:SGTC_2984|Compound:9022109|FD-Score:-3.44|P-value:3.28E-5 ID:SGTC_2986|Compound:9022445|FD-Score:2.78|P-value:6.05E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-4.29|P-value:3.21E-7 ID:SGTC_2991|Compound:9074669|FD-Score:4.48|P-value:9.43E-8 ID:SGTC_2997|Compound:9067075|FD-Score:2.84|P-value:4.70E-4 ID:SGTC_2999|Compound:9069765|FD-Score:2.81|P-value:5.47E-4 ID:SGTC_3099|Compound:9120367|FD-Score:-3.13|P-value:1.44E-4 ID:SGTC_3177|Compound:9107506|FD-Score:3.01|P-value:2.32E-4 ID:SGTC_3299|Compound:9121982|FD-Score:2.72|P-value:7.87E-4

Top fitness defect scores for YGR161W-C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2991 9074669 4.48 71.4 µM 9.43E-8 azole & statin 45 3.73E-6
2 SGTC_1455 4262-0120 4.46 131.0 µM 1.08E-7 plasma membrane duress 19 4.13E-6
3 SGTC_46 0329-0187a 4.39 2.2 µM 1.67E-7 56 5.71E-6
4 SGTC_1285 0929-0069 4.23 65.5 µM 4.36E-7 9 1.17E-5
5 SGTC_212 3807-4682 4.18 38.8 µM 5.75E-7 tubulin folding & SWR complex 59 1.44E-5
6 SGTC_550 4123-0385 4.06 25.7 µM 1.19E-6 TSC3-RPN4 17 2.49E-5
7 SGTC_1230 0170-0365 3.80 3.8 µM 5.05E-6 endomembrane recycling 74 7.36E-5
8 SGTC_37 0566-0070 3.74 1.6 µM 6.96E-6 35 9.36E-5
9 SGTC_1717 st033143 3.67 58.0 µM 1.00E-5 55 1.23E-4
10 SGTC_2139 5578692 3.59 56.5 µM 1.46E-5 superoxide 23 1.64E-4
11 SGTC_1714 st033236 3.35 13.6 µM 4.86E-5 46 4.04E-4
12 SGTC_2453 5731132 3.29 22.2 µM 6.36E-5 47 4.94E-4
13 SGTC_1908 st060353 3.16 56.5 µM 1.17E-4 RPP1 & pyrimidine depletion 75 7.81E-4
14 SGTC_3177 9107506 3.01 49.5 µM 2.32E-4 ERG2 28 0.00131
15 SGTC_2847 9005661 2.97 71.4 µM 2.69E-4 24 0.00147
16 SGTC_1217 1183-1422 2.93 255.0 µM 3.23E-4 54 0.00168
17 SGTC_842 0271-0008 2.91 11.1 µM 3.54E-4 heme biosynthesis & mitochondrial translocase 58 0.00180
18 SGTC_848 0368-0089 2.88 85.6 µM 4.03E-4 iron homeostasis 54 0.00199
19 SGTC_2997 9067075 2.84 71.4 µM 4.70E-4 unfolded protein response 117 0.00223
20 SGTC_2999 9069765 2.81 71.4 µM 5.47E-4 amide catabolism 91 0.00251

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 1.12E-33 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.192 4.14E-29 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.167 1.87E-22 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.163 2.34E-21 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.157 5.68E-20 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.149 3.31E-18 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.145 2.67E-17 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.141 2.29E-16 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.136 2.43E-15 YDR321W ASP1 hom Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia, has an important role in therapy of acute lymphoblastic leukemia; synthesized constitutively
0.134 7.86E-15 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.127 1.46E-13 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.74E-13 YFL004W VTC2 hom Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
0.124 5.03E-13 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.123 7.07E-13 YGR254W ENO1 hom Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress
0.121 2.15E-12 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose