HIPHOP chemogenomics database

YGR168C_p

Putative protein of unknown function; YGR168C is not an essential gene

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR168C / YGR168C

Click on Significant Values for Screen Details

Top fitness defect scores for YGR168C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1631	benzylvanillin	6.13	81.9 µM	4.77E-8	Golgi	5	4.28E-10
2	SGTC_954	1189-0853	5.96	2.9 µM	1.08E-7	endomembrane recycling	12	1.25E-9
3	SGTC_2240	6690706	5.83	185.9 µM	1.98E-7		4	2.76E-9
4	SGTC_1632	st005650	5.74	90.0 µM	2.95E-7		4	4.62E-9
5	SGTC_1901	st060216	5.46	58.6 µM	1.03E-6		11	2.38E-8
6	SGTC_2816	7982706	5.31	58.4 µM	1.96E-6	azole & statin	24	5.50E-8
7	SGTC_1800	st050079	5.01	29.1 µM	6.77E-6	NEO1-PIK1	74	2.76E-7
8	SGTC_3255	9139072	4.93	49.5 µM	9.21E-6		5	4.13E-7
9	SGTC_122	0236-0016	4.91	402.4 µM	9.90E-6	RNA processing & uracil transport	18	4.53E-7
10	SGTC_2334	9017922	4.90	200.0 µM	1.04E-5		7	4.81E-7
11	SGTC_2260	7964312	4.89	200.0 µM	1.07E-5		4	5.05E-7
12	SGTC_953	1188-0045	4.58	9.7 µM	3.50E-5	60S ribosome export	14	2.34E-6
13	SGTC_2975	9084847	4.49	53.7 µM	4.83E-5		14	3.57E-6
14	SGTC_1041	0206-0046	4.48	107.0 µM	5.07E-5		24	3.81E-6
15	SGTC_2858	9025781	4.44	9.0 µM	5.83E-5	sphingolipid biosynthesis & PDR1	78	4.56E-6
16	SGTC_2947	9072639	4.40	7.7 µM	6.65E-5	tubulin folding & SWR complex	30	5.41E-6
17	SGTC_1110	3-hydroxy-3'-methoxyflavone	4.38	1.2 µM	7.14E-5	iron homeostasis	34	5.94E-6
18	SGTC_2251	lansoprazole	4.37	556.0 µM	7.30E-5		14	6.12E-6
19	SGTC_1718	roemerine	4.27	11.9 µM	1.03E-4	redox potentiating	41	9.59E-6
20	SGTC_1028	k015-0029	4.26	4.8 µM	1.07E-4		16	1.00E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.133	1.07E-14	YDR492W	IZH1	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.096	2.59E-8	YDR520C_p	URC2_p	hom	Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism
0.096	2.93E-8	YBR213W	MET8	hom	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.095	3.20E-8	YGR178C	PBP1	hom	Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.091	1.38E-7	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.090	1.91E-7	YAR042W	SWH1	hom	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.087	4.58E-7	YDL015C	TSC13	het	Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.087	5.12E-7	YPR092W_d	YPR092W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086	5.98E-7	YDR491C_d	YDR491C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082	1.86E-6	YHR148W	IMP3	het	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.082	1.91E-6	YGR206W	MVB12	hom	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.081	2.67E-6	YDR084C	TVP23	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.081	2.85E-6	YPR091C	NVJ2	hom	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.079	4.86E-6	YKL191W	DPH2	hom	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
0.078	6.14E-6	YJL052W	TDH1	hom	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress