YGR181W / TIM13

Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR181W / TIM13

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.92|P-value:3.94E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:2.71|P-value:8.60E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.15|P-value:1.32E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.07|P-value:2.27E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.37|P-value:5.21E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.93|P-value:2.66E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:2.78|P-value:6.34E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.93|P-value:3.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:5.35|P-value:3.02E-10 ID:SGTC_623|Compound:k072-0108|FD-Score:2.70|P-value:8.84E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.10|P-value:1.67E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.32|P-value:6.01E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.37|P-value:4.88E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.01|P-value:2.48E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.79|P-value:6.12E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:2.68|P-value:9.39E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.87|P-value:3.80E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.79|P-value:6.14E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.33|P-value:6.34E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-2.78|P-value:6.85E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:2.77|P-value:6.73E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:6.65E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.14|P-value:1.52E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.80|P-value:5.89E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.93|P-value:3.44E-4 ID:SGTC_1648|Compound:st011736|FD-Score:2.70|P-value:8.88E-4 ID:SGTC_1658|Compound:st012944|FD-Score:2.92|P-value:3.61E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.16|P-value:7.38E-7 ID:SGTC_1722|Compound:st034304|FD-Score:-2.90|P-value:4.17E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-5.05|P-value:2.95E-9 ID:SGTC_1738|Compound:st035555|FD-Score:2.76|P-value:6.91E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.94|P-value:3.30E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.03|P-value:2.28E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.06|P-value:1.96E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.63|P-value:4.21E-8 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:5.04|P-value:2.75E-9 ID:SGTC_1930|Compound:st074634|FD-Score:-4.81|P-value:1.52E-8 ID:SGTC_1932|Compound:st074806|FD-Score:3.41|P-value:4.02E-5 ID:SGTC_1962|Compound:st076595|FD-Score:2.75|P-value:7.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.71|P-value:2.54E-8 ID:SGTC_2174|Compound:5790901|FD-Score:-3.89|P-value:3.70E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.19|P-value:1.09E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-2.70|P-value:9.47E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.29|P-value:7.64E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-4.00|P-value:2.01E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.81|P-value:6.07E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.79|P-value:6.60E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.81|P-value:5.68E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.76|P-value:6.90E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.34|P-value:2.61E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:6.93E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.79|P-value:6.28E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.85|P-value:4.77E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-2.89|P-value:4.46E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.84|P-value:4.86E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:1.25E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.53|P-value:2.19E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.01|P-value:2.46E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.79|P-value:6.16E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.84|P-value:5.06E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.21|P-value:5.53E-7 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.92|P-value:3.94E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:2.71|P-value:8.60E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.15|P-value:1.32E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:5.07|P-value:2.27E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.37|P-value:5.21E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.93|P-value:2.66E-6 ID:SGTC_146|Compound:3448-8650|FD-Score:2.78|P-value:6.34E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:2.93|P-value:3.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:5.35|P-value:3.02E-10 ID:SGTC_623|Compound:k072-0108|FD-Score:2.70|P-value:8.84E-4 ID:SGTC_725|Compound:1497-0963|FD-Score:3.10|P-value:1.67E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.32|P-value:6.01E-5 ID:SGTC_902|Compound:1120-0002|FD-Score:3.37|P-value:4.88E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.01|P-value:2.48E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:2.79|P-value:6.12E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:2.68|P-value:9.39E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.87|P-value:3.80E-6 ID:SGTC_1286|Compound:0929-0070|FD-Score:2.79|P-value:6.14E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.33|P-value:6.34E-5 ID:SGTC_1487|Compound:3970-0795|FD-Score:-2.78|P-value:6.85E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:2.77|P-value:6.73E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.30|P-value:6.65E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:-3.14|P-value:1.52E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:2.80|P-value:5.89E-4 ID:SGTC_1625|Compound:st003711|FD-Score:2.93|P-value:3.44E-4 ID:SGTC_1648|Compound:st011736|FD-Score:2.70|P-value:8.88E-4 ID:SGTC_1658|Compound:st012944|FD-Score:2.92|P-value:3.61E-4 ID:SGTC_1720|Compound:st037298|FD-Score:4.16|P-value:7.38E-7 ID:SGTC_1722|Compound:st034304|FD-Score:-2.90|P-value:4.17E-4 ID:SGTC_1723|Compound:st034307|FD-Score:-5.05|P-value:2.95E-9 ID:SGTC_1738|Compound:st035555|FD-Score:2.76|P-value:6.91E-4 ID:SGTC_1744|Compound:st037937|FD-Score:2.94|P-value:3.30E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.03|P-value:2.28E-4 ID:SGTC_1892|Compound:st058411|FD-Score:3.06|P-value:1.96E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.63|P-value:4.21E-8 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:5.04|P-value:2.75E-9 ID:SGTC_1930|Compound:st074634|FD-Score:-4.81|P-value:1.52E-8 ID:SGTC_1932|Compound:st074806|FD-Score:3.41|P-value:4.02E-5 ID:SGTC_1962|Compound:st076595|FD-Score:2.75|P-value:7.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.71|P-value:2.54E-8 ID:SGTC_2174|Compound:5790901|FD-Score:-3.89|P-value:3.70E-6 ID:SGTC_2253|Compound:7938677|FD-Score:3.19|P-value:1.09E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-2.70|P-value:9.47E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.29|P-value:7.64E-5 ID:SGTC_2347|Compound:9049783|FD-Score:-4.00|P-value:2.01E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-2.81|P-value:6.07E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.79|P-value:6.60E-4 ID:SGTC_2442|Compound:5158906|FD-Score:2.81|P-value:5.68E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:2.76|P-value:6.90E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:4.34|P-value:2.61E-7 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.31|P-value:6.93E-5 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.79|P-value:6.28E-6 ID:SGTC_2704|Compound:st078022|FD-Score:2.85|P-value:4.77E-4 ID:SGTC_2726|Compound:cimetidine|FD-Score:-2.89|P-value:4.46E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.84|P-value:4.86E-6 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.16|P-value:1.25E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.53|P-value:2.19E-5 ID:SGTC_2858|Compound:9025781|FD-Score:3.01|P-value:2.46E-4 ID:SGTC_2965|Compound:9082772|FD-Score:2.79|P-value:6.16E-4 ID:SGTC_3038|Compound:9091290|FD-Score:2.84|P-value:5.06E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.21|P-value:5.53E-7

Top fitness defect scores for YGR181W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_352 k048-0007 5.35 5.1 µM 3.02E-10 ERAD & cell cycle 41 4.32E-8
2 SGTC_141 0443-0274 5.07 32.3 µM 2.27E-9 mitochondrial response to ROS 21 1.98E-7
3 SGTC_1928 4'-methoxychalcone 5.04 40.3 µM 2.75E-9 3 2.29E-7
4 SGTC_2021 4019055 4.71 173.0 µM 2.54E-8 endomembrane recycling 76 1.23E-6
5 SGTC_1920 st075728 4.63 45.7 µM 4.21E-8 7 1.80E-6
6 SGTC_2541 muurolladie-3-one 4.34 83.1 µM 2.61E-7 excess fatty acid 18 7.19E-6
7 SGTC_3041 9091929 4.21 49.5 µM 5.53E-7 redox potentiating 18 1.27E-5
8 SGTC_1720 st037298 4.16 9.5 µM 7.38E-7 31 1.58E-5
9 SGTC_143 4032-1194 3.93 15.7 µM 2.66E-6 68 4.17E-5
10 SGTC_1230 0170-0365 3.87 3.8 µM 3.80E-6 endomembrane recycling 70 5.47E-5
11 SGTC_2766 oltipraz 3.53 83.9 µM 2.19E-5 heme requiring 47 2.07E-4
12 SGTC_1932 st074806 3.41 40.9 µM 4.02E-5 46 3.29E-4
13 SGTC_902 1120-0002 3.37 2.1 µM 4.88E-5 azole & statin 70 3.81E-4
14 SGTC_778 3456-2434 3.32 196.0 µM 6.01E-5 mitochondrial response to ROS 110 4.46E-4
15 SGTC_1585 2',4'-dihydroxychalcone 3.30 10.4 µM 6.65E-5 58 4.82E-4
16 SGTC_2253 7938677 3.19 135.8 µM 1.09E-4 35 7.03E-4
17 SGTC_2764 methyldopa 3.16 94.7 µM 1.25E-4 52 7.81E-4
18 SGTC_127 0180-0333 3.15 59.1 µM 1.32E-4 mitochondrial response to ROS 88 8.14E-4
19 SGTC_725 1497-0963 3.10 19.0 µM 1.67E-4 copper-dependent oxidative stress 50 9.71E-4
20 SGTC_1892 st058411 3.06 7.4 µM 1.96E-4 69 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.39E-16 YGR133W PEX4 hom Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
0.119 5.04E-12 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint
0.118 5.98E-12 YGR182C_d YGR182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W
0.114 3.25E-11 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR
0.113 5.11E-11 YOL073C YOL073C hom Subunit of the DSC ubiquitin ligase complex; ortholog of fission yeast dsc2
0.106 7.74E-10 YER079W_p YER079W_p hom Putative protein of unknown function
0.105 1.20E-9 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.31E-9 YJR088C EMC2 hom Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35
0.103 1.84E-9 YIL065C FIS1 hom Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation
0.103 1.95E-9 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.098 1.29E-8 YPL047W SGF11 hom Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
0.094 4.39E-8 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.093 6.51E-8 YLR188W MDL1 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress
0.091 1.48E-7 YOR190W SPR1 hom Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
0.090 1.88E-7 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p