HIPHOP chemogenomics database

YGR197C / SNG1

Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR197C / SNG1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR197C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2615	purpurogallin-4-carboxylic acid	17.30	100.0 µM	4.77E-77	redox potentiating	2	2.05E-67
2	SGTC_127	0180-0333	7.00	59.1 µM	3.28E-14	mitochondrial response to ROS	4	1.31E-12
3	SGTC_2052	5265182	5.69	7.1 µM	5.31E-10		5	6.23E-9
4	SGTC_1589	2',5'-dimethoxyflavone	4.51	47.2 µM	6.59E-7		7	3.17E-6
5	SGTC_554	4483-2211	4.51	187.0 µM	6.90E-7		11	3.31E-6
6	SGTC_767	0929-0023	4.40	86.0 µM	1.22E-6	TRP & mitochondrial translation	52	5.46E-6
7	SGTC_1894	3',6'-dihydroxyflavone	4.10	78.7 µM	5.64E-6		10	2.08E-5
8	SGTC_255	tunicamycin	3.77	200.5 nM	2.65E-5	unfolded protein response	83	8.08E-5
9	SGTC_1084	voriconazole	3.66	435.0 nM	4.37E-5	azole & statin	38	1.25E-4
10	SGTC_2181	6316240	3.50	54.3 µM	8.98E-5		34	2.36E-4
11	SGTC_1230	0170-0365	3.37	3.8 µM	1.54E-4	endomembrane recycling	104	3.79E-4
12	SGTC_575	k072-0246	3.32	11.9 µM	1.84E-4		43	4.42E-4
13	SGTC_1887	st057648	3.29	70.8 µM	2.11E-4		34	5.00E-4
14	SGTC_230	MPP+	3.26	141.7 µM	2.41E-4		42	5.62E-4
15	SGTC_10	0279-0212	3.19	42.6 µM	3.16E-4	TRP & mitochondrial translation	183	7.13E-4
16	SGTC_258	haloperidol	3.17	50.8 µM	3.38E-4	fatty acid desaturase (OLE1)	61	7.57E-4
17	SGTC_2657	nystatin	3.11	74.4 µM	4.34E-4		41	9.42E-4
18	SGTC_1252	0493-0875	3.04	34.8 µM	5.66E-4		73	0.00119
19	SGTC_288	1315-0019	3.04	35.1 µM	5.72E-4	RSC & ERG11	65	0.00120
20	SGTC_22	0964-0034	3.02	14.5 µM	6.11E-4	unfolded protein response	89	0.00127

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.267	9.98E-56	YOR162C	YRR1	hom	Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.226	2.88E-40	YOR382W	FIT2	hom	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.216	8.85E-37	YDR315C	IPK1	hom	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.201	6.81E-32	YBR157C	ICS2	hom	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
0.196	2.18E-30	YBL059W_p	YBL059W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.163	1.76E-21	YBR051W_d	YBR051W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
0.156	9.77E-20	YGL168W	HUR1	hom	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.141	2.52E-16	YDR173C	ARG82	hom	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
0.134	7.17E-15	YGL180W	ATG1	hom	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p
0.133	1.28E-14	YPL222W_p	FMP40_p	hom	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.124	4.95E-13	YBR151W	APD1	hom	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.117	1.16E-11	YMR279C	YMR279C	hom	Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication
0.117	1.32E-11	YLR304C	ACO1	hom	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.115	2.19E-11	YJL138C	TIF2	hom	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication
0.114	3.48E-11	YPR174C	YPR174C	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication