YGR203W / YCH1

Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR203W / YCH1

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:4.94E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.11|P-value:7.89E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.08|P-value:8.90E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.89|P-value:3.81E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.39|P-value:4.01E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:6.90|P-value:1.09E-12 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.21|P-value:5.09E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.60|P-value:1.28E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.92|P-value:3.10E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.88|P-value:3.64E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.07|P-value:8.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.29|P-value:3.72E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.25|P-value:3.98E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.93|P-value:2.96E-5 ID:SGTC_1637|Compound:st007924|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.37|P-value:4.70E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-3.77|P-value:5.76E-5 ID:SGTC_1710|Compound:st031758|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.56|P-value:1.49E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.07|P-value:8.46E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.84|P-value:4.88E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.20|P-value:5.86E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.70|P-value:7.67E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.47|P-value:1.94E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:3.74E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.26|P-value:4.73E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.41|P-value:1.88E-8 ID:SGTC_2219|Compound:9098279|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.17|P-value:6.38E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.12|P-value:7.79E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.83|P-value:4.99E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.23|P-value:5.20E-8 ID:SGTC_2606|Compound:farnesol|FD-Score:5.43|P-value:1.65E-8 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_2875|Compound:9039966|FD-Score:4.26|P-value:7.47E-6 ID:SGTC_2884|Compound:9058502|FD-Score:3.33|P-value:3.61E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.19|P-value:5.92E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.68|P-value:9.47E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.15|P-value:6.98E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.22|P-value:5.37E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.52|P-value:1.78E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.32|P-value:4.94E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.11|P-value:7.89E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:3.50|P-value:1.88E-4 ID:SGTC_290|Compound:2043-6722|FD-Score:3.13|P-value:7.45E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.48|P-value:1.87E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.08|P-value:8.90E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.89|P-value:3.81E-5 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.21|P-value:5.00E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:3.30|P-value:3.97E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.39|P-value:4.01E-6 ID:SGTC_955|Compound:1216-0110|FD-Score:6.90|P-value:1.09E-12 ID:SGTC_958|Compound:1222-0007|FD-Score:-3.21|P-value:5.09E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:3.07|P-value:9.21E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-4.60|P-value:1.28E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.92|P-value:3.10E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.88|P-value:3.64E-5 ID:SGTC_1253|Compound:0550-0034|FD-Score:-3.07|P-value:8.32E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.29|P-value:3.72E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-5.25|P-value:3.98E-8 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.93|P-value:2.96E-5 ID:SGTC_1637|Compound:st007924|FD-Score:4.16|P-value:1.19E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:6.37|P-value:4.70E-11 ID:SGTC_1682|Compound:st012968|FD-Score:-3.77|P-value:5.76E-5 ID:SGTC_1710|Compound:st031758|FD-Score:-3.20|P-value:5.27E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.56|P-value:1.49E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-3.07|P-value:8.46E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.84|P-value:4.88E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.20|P-value:5.86E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.70|P-value:7.67E-5 ID:SGTC_2116|Compound:5511452|FD-Score:-3.47|P-value:1.94E-4 ID:SGTC_2121|Compound:5257820|FD-Score:-3.29|P-value:3.74E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.26|P-value:4.73E-4 ID:SGTC_2184|Compound:6075246|FD-Score:5.41|P-value:1.88E-8 ID:SGTC_2219|Compound:9098279|FD-Score:3.23|P-value:5.16E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.17|P-value:6.38E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.12|P-value:7.79E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.83|P-value:4.99E-5 ID:SGTC_2493|Compound:resveratrol|FD-Score:3.62|P-value:1.20E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:5.23|P-value:5.20E-8 ID:SGTC_2606|Compound:farnesol|FD-Score:5.43|P-value:1.65E-8 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.57|P-value:1.27E-4 ID:SGTC_2875|Compound:9039966|FD-Score:4.26|P-value:7.47E-6 ID:SGTC_2884|Compound:9058502|FD-Score:3.33|P-value:3.61E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.19|P-value:5.92E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.68|P-value:9.47E-5 ID:SGTC_3232|Compound:9132874|FD-Score:3.15|P-value:6.98E-4 ID:SGTC_3281|Compound:9140613|FD-Score:3.22|P-value:5.37E-4

Top fitness defect scores for YGR203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_955 1216-0110 6.90 33.0 µM 1.09E-12 sphingolipid biosynthesis & PDR1 27 2.57E-12
2 SGTC_1681 tripelennamine 6.37 100.0 µM 4.70E-11 4 9.68E-11
3 SGTC_2606 farnesol 5.43 9.8 µM 1.65E-8 4 2.78E-8
4 SGTC_2184 6075246 5.41 200.0 µM 1.88E-8 6 3.15E-8
5 SGTC_2500 5-alpha-androstan-3,17-dione 5.23 61.4 µM 5.20E-8 18 8.40E-8
6 SGTC_789 1309-1135 4.39 70.6 µM 4.01E-6 ERG2 19 5.59E-6
7 SGTC_2875 9039966 4.26 71.4 µM 7.47E-6 7 1.02E-5
8 SGTC_1637 st007924 4.16 17.4 µM 1.19E-5 17 1.60E-5
9 SGTC_532 1548-0774 3.89 215.0 µM 3.81E-5 22 4.92E-5
10 SGTC_2044 5102272 3.84 200.0 µM 4.88E-5 11 6.26E-5
11 SGTC_2422 chlorphenesin carbamate 3.83 384.2 µM 4.99E-5 29 6.40E-5
12 SGTC_3000 9075062 3.68 71.4 µM 9.47E-5 29 1.19E-4
13 SGTC_2493 resveratrol 3.62 26.1 µM 1.20E-4 14 1.50E-4
14 SGTC_1747 st037496 3.56 66.6 µM 1.49E-4 27 1.84E-4
15 SGTC_18 0111-0177 3.52 500.0 nM 1.78E-4 88 2.19E-4
16 SGTC_212 3807-4682 3.50 38.8 µM 1.88E-4 tubulin folding & SWR complex 97 2.31E-4
17 SGTC_1831 st055328 3.35 12.0 µM 3.39E-4 heme biosynthesis & mitochondrial translocase 48 4.08E-4
18 SGTC_2884 9058502 3.33 52.0 µM 3.61E-4 49 4.34E-4
19 SGTC_776 4476-4378 3.30 112.0 µM 3.97E-4 ERG2 41 4.75E-4
20 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.26 49.5 µM 4.73E-4 48 5.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.48E-11 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.098 1.19E-8 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.096 2.17E-8 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.092 8.80E-8 YDR422C SIP1 hom Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions
0.090 1.56E-7 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
0.088 3.00E-7 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.088 3.79E-7 YDR282C_p YDR282C_p hom Putative protein of unknown function; localizes to the inner mitochondrial membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation
0.086 6.51E-7 YNR040W_p YNR040W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.082 1.84E-6 YGR139W_d YGR139W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 2.13E-6 YOR028C CIN5 hom Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication
0.081 2.42E-6 YLR103C CDC45 het DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes
0.081 2.74E-6 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.080 3.05E-6 YMR167W MLH1 hom Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
0.080 3.77E-6 YGR169C-A_p YGR169C-A_p hom Putative protein of unknown function; YGR169C-A has a paralog, YJR005C-A, that arose from the whole genome duplication
0.080 3.85E-6 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex