YGR205W / TDA10

ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR205W / TDA10

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:3.42|P-value:7.42E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.98|P-value:6.19E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:2.85|P-value:7.83E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.05|P-value:3.58E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.18|P-value:2.07E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:2.89|P-value:6.62E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.17|P-value:2.22E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.54|P-value:2.45E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.92|P-value:6.80E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.53|P-value:4.47E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.76|P-value:1.53E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.39|P-value:5.74E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:3.19|P-value:2.05E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.20|P-value:1.92E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.26|P-value:1.74E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:9.63E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.96|P-value:5.11E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.09|P-value:3.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.87|P-value:8.27E-4 ID:SGTC_2104|Compound:5389443|FD-Score:2.93|P-value:5.80E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:5.05E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.03|P-value:4.46E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.11|P-value:2.66E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.78|P-value:1.71E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.15|P-value:2.35E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.83|P-value:1.12E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.87|P-value:8.43E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.68|P-value:2.29E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:2.89|P-value:6.71E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.92|P-value:6.97E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.79|P-value:7.00E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.15|P-value:2.39E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.01|P-value:4.16E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.07|P-value:3.25E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.29|P-value:1.01E-6 ID:SGTC_3284|Compound:9108171|FD-Score:-3.35|P-value:1.18E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.42|P-value:7.42E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.98|P-value:6.19E-6 ID:SGTC_295|Compound:k015-0027|FD-Score:2.85|P-value:7.83E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.05|P-value:3.58E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:3.18|P-value:2.07E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:2.89|P-value:6.62E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.17|P-value:2.22E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:4.54|P-value:2.45E-7 ID:SGTC_747|Compound:3448-8087|FD-Score:-2.92|P-value:6.80E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:3.53|P-value:4.47E-5 ID:SGTC_809|Compound:3998-0021|FD-Score:3.76|P-value:1.53E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:4.39|P-value:5.74E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:3.19|P-value:2.05E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.20|P-value:1.92E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.26|P-value:1.74E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-3.21|P-value:2.17E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.36|P-value:9.63E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:2.96|P-value:5.11E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.09|P-value:3.02E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-2.87|P-value:8.27E-4 ID:SGTC_2104|Compound:5389443|FD-Score:2.93|P-value:5.80E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:5.05E-5 ID:SGTC_2112|Compound:5488546|FD-Score:-3.03|P-value:4.46E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.11|P-value:2.66E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.78|P-value:1.71E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.15|P-value:2.35E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.83|P-value:1.12E-5 ID:SGTC_2433|Compound:5607874|FD-Score:-2.87|P-value:8.43E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.68|P-value:2.29E-5 ID:SGTC_2723|Compound:salbutamol|FD-Score:2.89|P-value:6.71E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-2.92|P-value:6.97E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-4.79|P-value:7.00E-8 ID:SGTC_2833|Compound:9001315|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.15|P-value:2.39E-4 ID:SGTC_2889|Compound:9059656|FD-Score:3.01|P-value:4.16E-4 ID:SGTC_3109|Compound:9122853|FD-Score:3.07|P-value:3.25E-4 ID:SGTC_3161|Compound:9100388|FD-Score:4.29|P-value:1.01E-6 ID:SGTC_3284|Compound:9108171|FD-Score:-3.35|P-value:1.18E-4

Top fitness defect scores for YGR205W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_741 4582-0002 4.54 126.0 µM 2.45E-7 7 2.78E-6
2 SGTC_943 3253-1379 4.39 105.0 µM 5.74E-7 20 5.61E-6
3 SGTC_3161 9100388 4.29 49.5 µM 1.01E-6 iron homeostasis 7 8.95E-6
4 SGTC_2119 5528445 4.11 120.6 µM 2.66E-6 12 1.99E-5
5 SGTC_2424 5537928 3.83 59.2 µM 1.12E-5 40 6.50E-5
6 SGTC_809 3998-0021 3.76 90.0 µM 1.53E-5 RNA processing & uracil transport 15 8.45E-5
7 SGTC_2613 3',4'-dimethoxydalbergione 3.68 24.6 µM 2.29E-5 32 1.18E-4
8 SGTC_807 1315-0151 3.53 48.0 µM 4.47E-5 42 2.05E-4
9 SGTC_2105 5350118 3.51 200.0 µM 5.05E-5 43 2.26E-4
10 SGTC_43 0570-0105 3.42 72.5 µM 7.42E-5 ERG2 142 3.11E-4
11 SGTC_1347 1493-0251 3.36 600.0 nM 9.63E-5 mitochondrial response to ROS 33 3.86E-4
12 SGTC_980 1473-0395 3.20 201.0 µM 1.92E-4 31 6.85E-4
13 SGTC_944 3370-0224 3.19 231.0 µM 2.05E-4 61 7.23E-4
14 SGTC_521 r062-0005 3.18 13.8 µM 2.07E-4 41 7.28E-4
15 SGTC_729 4092-0585 3.17 94.1 µM 2.22E-4 52 7.71E-4
16 SGTC_2349 9023730 3.15 187.1 µM 2.35E-4 69 8.08E-4
17 SGTC_2882 9058044 3.15 58.4 µM 2.39E-4 45 8.20E-4
18 SGTC_2833 9001315 3.10 45.5 µM 2.94E-4 amide catabolism 94 9.73E-4
19 SGTC_1456 k015-0012 3.09 13.0 µM 3.02E-4 72 9.97E-4
20 SGTC_3109 9122853 3.07 49.5 µM 3.25E-4 30 0.00106

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.64E-15 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.125 4.42E-13 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.121 2.28E-12 YGR126W_p YGR126W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.117 1.12E-11 YFR017C IGD1 hom Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication
0.108 3.85E-10 YGL170C SPO74 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.107 5.75E-10 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.098 1.16E-8 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.097 1.74E-8 YMR180C CTL1 hom RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
0.096 2.61E-8 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 6.00E-8 YNR014W_p YNR014W_p hom Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication
0.090 1.73E-7 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.089 2.25E-7 YNL217W_p YNL217W_p hom Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
0.089 2.58E-7 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.086 5.75E-7 YGR177C ATF2 hom Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking
0.086 6.27E-7 YMR005W TAF4 het TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate