YGR209C / TRX2

Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR209C / TRX2

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:-5.65|P-value:3.81E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.30|P-value:1.68E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.57|P-value:4.74E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.11|P-value:3.29E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:2.95|P-value:6.05E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.02|P-value:5.20E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.09|P-value:3.50E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.09|P-value:3.94E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.84|P-value:9.32E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.25|P-value:1.88E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:3.42E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.27|P-value:1.88E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.07|P-value:4.31E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.06|P-value:4.03E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:2.85|P-value:8.80E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.99|P-value:7.33E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-2.93|P-value:7.29E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-5.65|P-value:3.81E-10 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.30|P-value:1.68E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:3.57|P-value:4.74E-5 ID:SGTC_334|Compound:1502-1024|FD-Score:3.11|P-value:3.29E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:2.95|P-value:6.05E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.02|P-value:5.20E-4 ID:SGTC_1138|Compound:3761-0006|FD-Score:3.09|P-value:3.50E-4 ID:SGTC_1145|Compound:3546-0597|FD-Score:-3.09|P-value:3.94E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.06|P-value:3.99E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:2.84|P-value:9.32E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.25|P-value:1.88E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.13|P-value:3.42E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.27|P-value:1.88E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:4.07|P-value:4.31E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.06|P-value:4.03E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:2.85|P-value:8.80E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.99|P-value:7.33E-6 ID:SGTC_2939|Compound:9044578|FD-Score:-3.23|P-value:2.30E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-2.93|P-value:7.29E-4

Top fitness defect scores for YGR209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1499 4480-0877 4.07 67.3 µM 4.31E-6 5 2.40E-5
2 SGTC_159 3970-0959 3.57 50.0 µM 4.74E-5 105 1.82E-4
3 SGTC_334 1502-1024 3.11 68.5 µM 3.29E-4 36 9.38E-4
4 SGTC_1138 3761-0006 3.09 1.0 µM 3.50E-4 27 9.87E-4
5 SGTC_1230 0170-0365 3.06 3.8 µM 3.99E-4 endomembrane recycling 132 0.00110
6 SGTC_2563 tomatine 3.06 8.5 µM 4.03E-4 104 0.00111
7 SGTC_377 3970-0964 2.95 33.1 µM 6.05E-4 114 0.00157
8 SGTC_2615 purpurogallin-4-carboxylic acid 2.85 100.0 µM 8.80E-4 redox potentiating 134 0.00216
9 SGTC_1390 3413-2614 2.84 145.0 µM 9.32E-4 fatty acid desaturase (OLE1) 82 0.00226
10 SGTC_1132 3456-3614 2.77 2.5 µM 0.00118 tubulin folding & SWR complex 146 0.00276
11 SGTC_406 estrone 2.76 100.0 µM 0.00123 59 0.00287
12 SGTC_2634 4'-methoxyflavone 2.76 100.0 µM 0.00126 101 0.00292
13 SGTC_3072 9116419 2.75 49.5 µM 0.00129 ERG2 78 0.00298
14 SGTC_2035 5154463 2.69 94.6 µM 0.00157 95 0.00353
15 SGTC_1983 st071813 2.69 46.9 µM 0.00160 RPP1 & pyrimidine depletion 82 0.00359
16 SGTC_1248 0469-0687 2.53 58.6 µM 0.00276 128 0.00570
17 SGTC_1758 st042942 2.53 75.2 µM 0.00278 95 0.00573
18 SGTC_2354 9060492 2.47 162.0 µM 0.00341 121 0.00682
19 SGTC_431 k089-0097 2.37 107.0 µM 0.00460 iron homeostasis 198 0.00879
20 SGTC_1911 st060208 2.35 74.3 µM 0.00499 152 0.00942

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 4.01E-61 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.277 4.73E-60 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.265 1.23E-54 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.255 1.10E-50 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.252 1.60E-49 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.242 6.81E-46 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.232 2.21E-42 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.224 1.95E-39 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.220 5.35E-38 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.215 2.19E-36 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.213 1.44E-35 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.212 1.40E-35 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.211 3.68E-35 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.205 3.73E-33 YCL026C-A FRM2 hom Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.202 3.37E-32 YJR058C APS2 hom Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex