HIPHOP chemogenomics database

YGR216C / GPI1

Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs

Zygosity: Heterozygous strain

fixedexpanded
Profile for YGR216C / GPI1

Click on Significant Values for Screen Details

Top fitness defect scores for YGR216C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2967	9089538	6.36	49.9 µM	6.28E-16		2	1.01E-10	0.77
2	SGTC_2973	9094665	6.17	18.0 µM	4.06E-15	NEO1	6	3.35E-10	0.39
3	SGTC_763	3453-1109	3.28	128.0 µM	1.67E-5		11	5.20E-4	0.12
4	SGTC_916	4466-0038	3.07	42.0 nM	4.99E-5	cell wall	41	0.00106	0.04
5	SGTC_1686	st019653	2.92	115.5 µM	1.07E-4	mitochondrial processes	15	0.00175	0.01
6	SGTC_1370	2001-0092	2.88	44.6 µM	1.32E-4		16	0.00199	0.01
7	SGTC_1136	pergolide	2.86	1.1 µM	1.47E-4		38	0.00215	0.00
8	SGTC_2965	9082772	2.79	38.6 µM	1.98E-4	mitochondrial response to ROS	7	0.00260	0.06
9	SGTC_1135	dihydrocapsaicin	2.71	536.7 nM	2.87E-4		20	0.00332	0.05
10	SGTC_1403	3909-7815	2.71	62.9 µM	2.95E-4		15	0.00338	0.10
11	SGTC_2970	9090938	2.70	41.9 µM	3.09E-4	RNA processing & uracil transport	31	0.00348	0.00
12	SGTC_2583	asiatic acid	2.61	100.0 µM	4.54E-4		33	0.00448	0.06
13	SGTC_968	1309-0633	2.61	340.0 µM	4.59E-4		22	0.00451	0.03
14	SGTC_1008	4106-0037	2.61	6.0 µM	4.64E-4	PDR1	22	0.00454	0.00
15	SGTC_525	k781-2675	2.60	26.7 µM	4.86E-4	redox potentiating	71	0.00468	0.02
16	SGTC_535	2293-4129	2.50	48.2 µM	7.47E-4	NEO1	36	0.00620	0.03
17	SGTC_2688	kanamycin b	2.48	96.7 µM	8.18E-4	calcium & mitochondrial duress	60	0.00658	0.04
18	SGTC_2918	7977171	2.47	22.1 µM	8.62E-4		22	0.00681	0.04
19	SGTC_1230	0170-0365	2.46	3.8 µM	8.90E-4	endomembrane recycling	48	0.00696	0.05
20	SGTC_2160	5660466	2.45	132.9 µM	9.23E-4	60S ribosome export	38	0.00713	0.03

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.234	3.68E-43	YEL049W	PAU2	hom	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.211	3.77E-35	YML100W	TSL1	hom	Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
0.208	4.12E-34	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.199	3.57E-31	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.196	2.16E-30	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.193	1.71E-29	YHR003C	YHR003C	hom	Protein of unknown function, localized to the mitochondrial outer membrane
0.191	8.84E-29	YGR251W	NOP19	het	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.186	1.21E-27	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.183	1.17E-26	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.183	1.39E-26	YKL141W	SDH3	het	Subunit of both succinate dehydrogenase and of TIM22 translocase; functions as the cytochrome b subunit of succinate dehydrogenase, which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex
0.182	2.42E-26	YKL066W_d	YKL066W_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.181	4.20E-26	YMR149W	SWP1	het	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
0.180	6.09E-26	YER064C	VHR2	hom	Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.174	3.10E-24	YKR023W_p	YKR023W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.174	3.79E-24	YLR267W_p	BOP2_p	hom	Protein of unknown function