YGR217W / CCH1

Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR217W / CCH1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:17.10|P-value:6.20E-72 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.00|P-value:7.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:18.40|P-value:5.34E-83 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.42|P-value:1.62E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:9.00|P-value:3.12E-21 ID:SGTC_304|Compound:1310-0298|FD-Score:4.37|P-value:2.90E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:7.88|P-value:1.05E-16 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.27|P-value:2.76E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.58|P-value:7.08E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:8.59|P-value:1.79E-19 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.71|P-value:6.03E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.03|P-value:8.59E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.29|P-value:3.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.89|P-value:2.05E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.93|P-value:2.31E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.30|P-value:3.11E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.01|P-value:7.17E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.97|P-value:1.88E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.19|P-value:3.75E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.81|P-value:2.82E-7 ID:SGTC_2339|Compound:9000433|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.13|P-value:5.97E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.11|P-value:9.96E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.03|P-value:6.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.94|P-value:2.51E-13 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.00|P-value:7.51E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.04|P-value:8.19E-8 ID:SGTC_2692|Compound:st077426|FD-Score:-3.26|P-value:2.80E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.94|P-value:9.34E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.99|P-value:1.28E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.25|P-value:3.00E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:3.78E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.14|P-value:5.74E-4 ID:SGTC_3343|Compound:9148379|FD-Score:2.99|P-value:9.99E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:17.10|P-value:6.20E-72 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.00|P-value:7.51E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:18.40|P-value:5.34E-83 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.42|P-value:1.62E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:2.26E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.34|P-value:2.10E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:9.00|P-value:3.12E-21 ID:SGTC_304|Compound:1310-0298|FD-Score:4.37|P-value:2.90E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:7.88|P-value:1.05E-16 ID:SGTC_371|Compound:0195-0006|FD-Score:-3.27|P-value:2.76E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-4.58|P-value:7.08E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:8.59|P-value:1.79E-19 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.71|P-value:6.03E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.03|P-value:8.59E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.29|P-value:3.26E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.89|P-value:2.05E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.93|P-value:2.31E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.30|P-value:3.11E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.01|P-value:7.17E-4 ID:SGTC_1831|Compound:st055328|FD-Score:3.97|P-value:1.88E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.28|P-value:3.45E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.19|P-value:3.75E-4 ID:SGTC_2334|Compound:9017922|FD-Score:4.81|P-value:2.82E-7 ID:SGTC_2339|Compound:9000433|FD-Score:3.03|P-value:8.55E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.13|P-value:5.97E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.11|P-value:9.96E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.17|P-value:5.22E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.03|P-value:6.65E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.94|P-value:2.51E-13 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.00|P-value:7.51E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.16|P-value:5.39E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.04|P-value:8.19E-8 ID:SGTC_2692|Compound:st077426|FD-Score:-3.26|P-value:2.80E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.94|P-value:9.34E-4 ID:SGTC_2942|Compound:9052777|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-3.99|P-value:1.28E-5 ID:SGTC_2953|Compound:9074162|FD-Score:-3.25|P-value:3.00E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.25|P-value:3.78E-4 ID:SGTC_3037|Compound:9091026|FD-Score:3.44|P-value:1.80E-4 ID:SGTC_3145|Compound:9085516|FD-Score:3.47|P-value:1.61E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.14|P-value:5.74E-4 ID:SGTC_3343|Compound:9148379|FD-Score:2.99|P-value:9.99E-4

Top fitness defect scores for YGR217W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 18.40 35.0 µM 5.34E-83 calcium & mitochondrial duress 3 2.99E-76
2 SGTC_58 0957-0393 17.10 9.0 µM 6.20E-72 cell wall 22 4.00E-66
3 SGTC_299 1273-0059 9.00 1.4 µM 3.12E-21 1 1.10E-19
4 SGTC_457 grayanotoxin iii 8.59 135.0 µM 1.79E-19 8 4.54E-18
5 SGTC_310 1273-0058 7.88 1.1 µM 1.05E-16 mitochondrial stress 94 1.58E-15
6 SGTC_2582 agaric acid 6.94 100.0 µM 2.51E-13 redox potentiating 130 2.00E-12
7 SGTC_2688 kanamycin b 5.04 96.7 µM 8.19E-8 calcium & mitochondrial duress 240 2.37E-7
8 SGTC_2334 9017922 4.81 200.0 µM 2.82E-7 8 7.39E-7
9 SGTC_304 1310-0298 4.37 97.0 µM 2.90E-6 cell wall 51 6.34E-6
10 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.11 3.7 µM 9.96E-6 77 1.98E-5
11 SGTC_1831 st055328 3.97 12.0 µM 1.88E-5 heme biosynthesis & mitochondrial translocase 24 3.56E-5
12 SGTC_1139 k015-0024 3.93 46.9 µM 2.31E-5 PDR1 14 4.32E-5
13 SGTC_1029 k015-0030 3.71 64.7 µM 6.03E-5 34 1.05E-4
14 SGTC_2942 9052777 3.51 62.2 µM 1.36E-4 52 2.22E-4
15 SGTC_1317 1273-0028 3.48 910.0 nM 1.55E-4 azole & statin 70 2.52E-4
16 SGTC_3145 9085516 3.47 49.5 µM 1.61E-4 fatty acid desaturase (OLE1) 45 2.60E-4
17 SGTC_3037 9091026 3.44 49.5 µM 1.80E-4 NEO1-PIK1 158 2.88E-4
18 SGTC_155 k072-0202 3.38 43.6 µM 2.26E-4 31 3.56E-4
19 SGTC_1347 1493-0251 3.30 600.0 nM 3.11E-4 mitochondrial response to ROS 37 4.78E-4
20 SGTC_1087 pterostilbene 3.29 9.1 µM 3.26E-4 54 5.00E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 7.83E-157 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.382 4.55E-117 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.348 4.49E-96 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.341 6.57E-92 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.338 3.81E-90 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.314 8.79E-78 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.313 2.93E-77 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.302 9.95E-72 YNL211C_p YNL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene
0.299 1.69E-70 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.299 4.67E-70 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.288 3.99E-65 YJL187C SWE1 hom Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
0.284 4.11E-63 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.279 6.92E-61 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.275 2.41E-59 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.272 5.93E-58 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication