YGR220C / MRPL9

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR220C / MRPL9

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:4.90|P-value:3.35E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.20|P-value:9.75E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.69|P-value:4.08E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:16.80|P-value:2.99E-64 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.27|P-value:3.73E-17 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.81|P-value:9.24E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:11.30|P-value:1.92E-30 ID:SGTC_365|Compound:0121-0052|FD-Score:3.11|P-value:7.28E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.02|P-value:2.89E-16 ID:SGTC_778|Compound:3456-2434|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.14|P-value:6.51E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.06|P-value:8.66E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.32|P-value:3.44E-8 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.47|P-value:3.49E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-7.07|P-value:1.37E-12 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.82|P-value:9.03E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.26|P-value:7.44E-6 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.33|P-value:3.32E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.23|P-value:4.72E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.40|P-value:4.01E-14 ID:SGTC_1707|Compound:st032323|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.02|P-value:9.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.31|P-value:3.58E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.90|P-value:6.63E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-7.50|P-value:5.72E-14 ID:SGTC_2784|Compound:7567673|FD-Score:-5.62|P-value:1.44E-8 ID:SGTC_2788|Compound:5282734|FD-Score:4.24|P-value:8.15E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-3.39|P-value:4.67E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.59|P-value:1.22E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.90|P-value:3.35E-7 ID:SGTC_134|Compound:0269-0018|FD-Score:4.20|P-value:9.75E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:5.69|P-value:4.08E-9 ID:SGTC_236|Compound:1509-0011|FD-Score:16.80|P-value:2.99E-64 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.27|P-value:3.73E-17 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.81|P-value:9.24E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:11.30|P-value:1.92E-30 ID:SGTC_365|Compound:0121-0052|FD-Score:3.11|P-value:7.28E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:8.02|P-value:2.89E-16 ID:SGTC_778|Compound:3456-2434|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_851|Compound:0394-0702|FD-Score:3.14|P-value:6.51E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.06|P-value:8.66E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:5.32|P-value:3.44E-8 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.47|P-value:3.49E-4 ID:SGTC_941|Compound:3237-0776|FD-Score:3.40|P-value:2.53E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-7.07|P-value:1.37E-12 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.82|P-value:9.03E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:4.26|P-value:7.44E-6 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.33|P-value:3.32E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.23|P-value:4.72E-4 ID:SGTC_1635|Compound:st007035|FD-Score:7.40|P-value:4.01E-14 ID:SGTC_1707|Compound:st032323|FD-Score:-3.79|P-value:1.00E-4 ID:SGTC_1739|Compound:st037196|FD-Score:3.02|P-value:9.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.31|P-value:3.58E-8 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.90|P-value:6.63E-5 ID:SGTC_2781|Compound:5567276|FD-Score:-7.50|P-value:5.72E-14 ID:SGTC_2784|Compound:7567673|FD-Score:-5.62|P-value:1.44E-8 ID:SGTC_2788|Compound:5282734|FD-Score:4.24|P-value:8.15E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-3.39|P-value:4.67E-4 ID:SGTC_2803|Compound:7707263|FD-Score:3.59|P-value:1.22E-4

Top fitness defect scores for YGR220C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 16.80 5.3 µM 2.99E-64 80 1.03E-63
2 SGTC_310 1273-0058 11.30 1.1 µM 1.92E-30 mitochondrial stress 27 4.48E-30
3 SGTC_275 trichlorophene 8.27 5.7 µM 3.73E-17 mitochondrial stress 71 6.96E-17
4 SGTC_386 1509-0011 8.02 3.1 µM 2.89E-16 63 5.30E-16
5 SGTC_1635 st007035 7.40 42.4 µM 4.01E-14 107 7.03E-14
6 SGTC_173 1273-0061 5.69 2.7 µM 4.08E-9 mitochondrial stress 118 6.33E-9
7 SGTC_908 3448-7491 5.32 47.7 µM 3.44E-8 mitochondrial stress 67 5.19E-8
8 SGTC_1742 st038235 5.31 28.9 µM 3.58E-8 mitochondrial stress 67 5.40E-8
9 SGTC_70 0141-0289 4.90 43.3 µM 3.35E-7 mitochondrial stress 114 4.91E-7
10 SGTC_1188 1403-0014 4.26 4.6 µM 7.44E-6 mitochondrial stress 43 1.04E-5
11 SGTC_2788 5282734 4.24 71.4 µM 8.15E-6 33 1.14E-5
12 SGTC_134 0269-0018 4.20 6.9 µM 9.75E-6 123 1.36E-5
13 SGTC_2803 7707263 3.59 71.4 µM 1.22E-4 37 1.63E-4
14 SGTC_941 3237-0776 3.40 460.0 µM 2.53E-4 37 3.34E-4
15 SGTC_1332 1480-0653 3.33 17.5 µM 3.32E-4 TSC3-RPN4 34 4.35E-4
16 SGTC_1371 2421-0008 3.23 32.7 µM 4.72E-4 mitochondrial processes 77 6.15E-4
17 SGTC_778 3456-2434 3.15 196.0 µM 6.28E-4 mitochondrial response to ROS 121 8.14E-4
18 SGTC_851 0394-0702 3.14 453.0 µM 6.51E-4 mitochondrial processes 32 8.42E-4
19 SGTC_365 0121-0052 3.11 13.6 µM 7.28E-4 mitochondrial response to ROS 116 9.40E-4
20 SGTC_861 0443-0273 3.06 110.0 µM 8.66E-4 44 0.00111

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.669 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.660 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.656 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.627 0 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.611 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.609 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.605 0 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.603 0 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.600 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.593 2.55E-317 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.585 5.70E-307 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.578 2.26E-298 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.572 1.30E-290 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.569 1.17E-287 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.569 1.87E-287 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit