HIPHOP chemogenomics database

YGR232W / NAS6

Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6

Zygosity: Homozygous strain

fixedexpanded
Profile for YGR232W / NAS6

Click on Significant Values for Screen Details

Top fitness defect scores for YGR232W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_932	2857-0803	6.83	154.0 µM	1.07E-11		4	4.26E-12
2	SGTC_2945	9067681	6.31	61.8 µM	3.15E-10		4	1.43E-10
3	SGTC_378	3970-0959	5.93	8.3 µM	2.97E-9		2	1.48E-9
4	SGTC_1454	4239-0054	4.93	42.6 µM	6.57E-7		11	4.03E-7
5	SGTC_6	0844-0013	4.86	19.8 µM	9.58E-7		42	5.96E-7
6	SGTC_2950	9072895	4.52	21.5 µM	4.60E-6		23	3.04E-6
7	SGTC_940	3232-1287	4.50	54.8 µM	5.07E-6	NEO1	22	3.36E-6
8	SGTC_1936	st074407	4.29	74.3 µM	1.32E-5	DNA damage response	24	9.11E-6
9	SGTC_2330	7979373	4.15	200.0 µM	2.38E-5	60S ribosome export	31	1.67E-5
10	SGTC_704	1310-0270	4.10	142.0 µM	2.91E-5		31	2.06E-5
11	SGTC_935	2996-0153	4.06	430.0 µM	3.47E-5	PDR1	18	2.48E-5
12	SGTC_328	k915-0120	3.88	63.5 µM	7.11E-5	TSC3-RPN4	23	5.22E-5
13	SGTC_1342	1486-1464	3.83	234.0 µM	8.50E-5		19	6.28E-5
14	SGTC_2183	6420625	3.82	130.5 µM	8.86E-5	mitochondrial processes	64	6.55E-5
15	SGTC_2865	9030313	3.80	52.0 µM	9.66E-5		15	7.17E-5
16	SGTC_1785	bathophenanthroline	3.76	24.0 µM	1.14E-4	heme requiring	58	8.51E-5
17	SGTC_1868	st057644	3.76	42.7 µM	1.15E-4		43	8.63E-5
18	SGTC_669	0108-0021	3.72	26.2 µM	1.35E-4	fatty acid desaturase (OLE1)	93	1.01E-4
19	SGTC_2792	7535235	3.71	81.8 µM	1.37E-4	fatty acid desaturase (OLE1)	41	1.03E-4
20	SGTC_2786	7743617	3.64	45.5 µM	1.78E-4		36	1.35E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.107	5.67E-10	YKL179C	COY1	hom	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.103	2.50E-9	YOR155C	ISN1	hom	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.094	5.49E-8	YLR458W_d	YLR458W_d	het	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis
0.090	1.66E-7	YNR071C_p	YNR071C_p	hom	Putative aldose 1-epimerase
0.089	2.49E-7	YBR274W	CHK1	hom	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.087	4.04E-7	YBL106C	SRO77	hom	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.085	7.82E-7	YNL065W	AQR1	hom	Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.085	9.28E-7	YOR215C	AIM41	hom	Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.084	1.07E-6	YMR226C	YMR226C	hom	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.082	2.01E-6	YIL009C-A	EST3	hom	Component of the telomerase holoenzyme, involved in telomere replication
0.082	2.06E-6	YEL023C_p	YEL023C_p	hom	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.080	3.23E-6	YJL211C_d	YJL211C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.079	4.73E-6	YNR009W	NRM1	hom	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
0.079	4.86E-6	YBR107C	IML3	hom	Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.078	6.15E-6	YCR064C_d	YCR064C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31