YGR235C / MOS2

Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture

Zygosity: Homozygous strain
fixedexpanded
Profile for YGR235C / MOS2

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:3.49|P-value:3.28E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.02|P-value:2.56E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.72|P-value:8.86E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.17|P-value:9.85E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.25|P-value:5.04E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.95|P-value:5.57E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.59|P-value:3.37E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.34|P-value:5.60E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.46|P-value:3.62E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.26|P-value:1.52E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.24|P-value:7.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.12|P-value:7.91E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.19|P-value:6.29E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.38|P-value:4.83E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.21|P-value:1.11E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.19|P-value:9.37E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.29|P-value:4.39E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.25|P-value:7.67E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.07|P-value:9.32E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.15|P-value:7.26E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.36|P-value:5.20E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.68|P-value:1.57E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.43|P-value:4.04E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.15|P-value:2.42E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.20|P-value:8.94E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:9.29|P-value:2.23E-20 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.73|P-value:1.69E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.19|P-value:6.17E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.79|P-value:6.50E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.96|P-value:3.35E-5 ID:SGTC_3073|Compound:9114972|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.33|P-value:5.79E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.40|P-value:4.46E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:3.49|P-value:3.28E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.02|P-value:2.56E-5 ID:SGTC_49|Compound:0717-0965|FD-Score:-3.51|P-value:1.94E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.72|P-value:8.86E-5 ID:SGTC_52|Compound:0329-0193|FD-Score:3.17|P-value:9.85E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.78|P-value:1.08E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.25|P-value:5.04E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:3.95|P-value:5.57E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:4.59|P-value:3.37E-6 ID:SGTC_765|Compound:1319-0117|FD-Score:3.34|P-value:5.60E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.46|P-value:3.62E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:4.26|P-value:1.52E-5 ID:SGTC_847|Compound:0342-0274|FD-Score:3.24|P-value:7.86E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.12|P-value:7.91E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:-3.19|P-value:6.29E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.38|P-value:4.83E-4 ID:SGTC_1519|Compound:esterone|FD-Score:-4.21|P-value:1.11E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.19|P-value:9.37E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.29|P-value:4.39E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.25|P-value:7.67E-4 ID:SGTC_1590|Compound:st077108|FD-Score:-3.66|P-value:1.11E-4 ID:SGTC_1622|Compound:st003707|FD-Score:-3.07|P-value:9.32E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.15|P-value:7.26E-4 ID:SGTC_1725|Compound:st036284|FD-Score:3.36|P-value:5.20E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.78|P-value:1.09E-4 ID:SGTC_1798|Compound:st045719|FD-Score:3.68|P-value:1.57E-4 ID:SGTC_2035|Compound:5154463|FD-Score:-3.61|P-value:1.36E-4 ID:SGTC_2120|Compound:5538279|FD-Score:3.43|P-value:4.04E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:4.15|P-value:2.42E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.20|P-value:8.94E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.21|P-value:8.62E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:9.29|P-value:2.23E-20 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.73|P-value:1.69E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.19|P-value:6.17E-4 ID:SGTC_2819|Compound:7996655|FD-Score:-3.79|P-value:6.50E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.96|P-value:3.35E-5 ID:SGTC_3073|Compound:9114972|FD-Score:-3.64|P-value:1.17E-4 ID:SGTC_3151|Compound:9099821|FD-Score:3.33|P-value:5.79E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.23|P-value:8.14E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.40|P-value:4.46E-4

Top fitness defect scores for YGR235C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2632 3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone 9.29 100.0 µM 2.23E-20 1 7.41E-21
2 SGTC_2635 hydroquinidine 4.73 100.0 µM 1.69E-6 10 1.10E-6
3 SGTC_672 1441-0018 4.59 53.7 µM 3.37E-6 10 2.23E-6
4 SGTC_808 0711-0032 4.26 135.0 µM 1.52E-5 9 1.04E-5
5 SGTC_2589 lobaric acid 4.15 100.0 µM 2.42E-5 22 1.68E-5
6 SGTC_392 N-ethylmaleimide 3.95 8.3 µM 5.57E-5 RNA pol III & RNase P/MRP 16 3.95E-5
7 SGTC_275 trichlorophene 3.78 5.7 µM 1.08E-4 mitochondrial stress 239 7.78E-5
8 SGTC_1773 st048542 3.78 73.6 µM 1.09E-4 47 7.84E-5
9 SGTC_2317 5986382 3.72 200.0 µM 1.35E-4 18 9.79E-5
10 SGTC_1798 st045719 3.68 61.0 µM 1.57E-4 14 1.14E-4
11 SGTC_35 0133-0054 3.49 64.1 µM 3.28E-4 45 2.44E-4
12 SGTC_795 0685-0265 3.46 78.0 µM 3.62E-4 excess fatty acid 38 2.70E-4
13 SGTC_2120 5538279 3.43 152.0 µM 4.04E-4 29 3.02E-4
14 SGTC_3337 9144342 3.40 33.5 µM 4.46E-4 42 3.34E-4
15 SGTC_1280 0880-0253 3.38 10.1 µM 4.83E-4 34 3.63E-4
16 SGTC_1725 st036284 3.36 20.6 µM 5.20E-4 56 3.91E-4
17 SGTC_765 1319-0117 3.34 244.0 µM 5.60E-4 60S ribosome export 21 4.22E-4
18 SGTC_3151 9099821 3.33 49.5 µM 5.79E-4 41 4.38E-4
19 SGTC_1587 estradiol valerate 3.25 56.1 µM 7.67E-4 34 5.84E-4
20 SGTC_847 0342-0274 3.24 5.5 µM 7.86E-4 41 5.99E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.57E-16 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.097 1.76E-8 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.090 2.09E-7 YGL192W IME4 hom Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids
0.083 1.47E-6 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.082 2.29E-6 YLR078C BOS1 het v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
0.081 2.72E-6 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.080 3.56E-6 YFL036W RPO41 hom Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.080 3.52E-6 YNL116W DMA2 hom Ubiquitin-protein ligase (E3); controls septin dynamics and the spindle position checkpoint (SPOC) along with functionally redundant ligase Dma1p by regulating the recruitment of Elm1p to the bud neck; regulates levels of the translation initiation factor eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8 protein, with sequence similarity to human Chfr; contains FHA and RING finger domains
0.078 6.96E-6 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.077 7.39E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.075 1.35E-5 YMR089C YTA12 hom Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
0.075 1.38E-5 YNL249C MPA43 hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.073 2.28E-5 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.072 2.88E-5 YML058W-A HUG1 hom Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress
0.072 3.08E-5 YLR115W CFT2 het Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.